Search Results - "VILLA, Alessandra"

Role of lipid composition on the structural and mechanical features of axonal membranes: a molecular simulation study by Saeedimasine, Marzieh, Montanino, Annaclaudia, Kleiven, Svein, Villa, Alessandra

“…The integrity of cellular membranes is critical for the functionality of axons. Failure of the axonal membranes (plasma membrane and/or myelin sheath) can be…”
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Sequence dependency of canonical base pair opening in the DNA double helix by Lindahl, Viveca, Villa, Alessandra, Hess, Berk

“…The flipping-out of a DNA base from the double helical structure is a key step of many cellular processes, such as DNA replication, modification and repair…”
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Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility by Nishimura, Kaoru, Dioguardi, Elisa, Nishio, Shunsuke, Villa, Alessandra, Han, Ling, Matsuda, Tsukasa, Jovine, Luca

“…Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP), whose ZP1 subunit is important for fertility by covalently cross-linking…”
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An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease by Dakhel, Sheila, Lizak, Christian, Matasci, Mattia, Mock, Jacqueline, Villa, Alessandra, Neri, Dario, Cazzamalli, Samuele

“…Antibody-cytokine fusion proteins (immunocytokines) are gaining importance for cancer therapy, but those products are often limited by systemic toxicity…”
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A biomolecular force field based on the free enthalpy of hydration and solvation: The GROMOS force-field parameter sets 53A5 and 53A6 by Oostenbrink, Chris, Villa, Alessandra, Mark, Alan E., Van Gunsteren, Wilfred F.

“…Successive parameterizations of the GROMOS force field have been used successfully to simulate biomolecular systems over a long period of time. The continuing…”
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The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases by RYBAK, Jascha-N, ROESLI, Christoph, KASPAR, Manuela, VILLA, Alessandra, NERI, Dario

“…One of the most promising new avenues for the development of more selective and efficacious cancer therapies relies on the antibody-mediated targeted delivery…”
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L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling by Giordano, Marco, Decio, Alessandra, Battistini, Chiara, Baronio, Micol, Bianchi, Fabrizio, Villa, Alessandra, Bertalot, Giovanni, Freddi, Stefano, Lupia, Michela, Jodice, Maria Giovanna, Ubezio, Paolo, Colombo, Nicoletta, Giavazzi, Raffaella, Cavallaro, Ugo

“…Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well…”
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Structural Basis of Egg Coat-Sperm Recognition at Fertilization by Raj, Isha, Sadat Al Hosseini, Hamed, Dioguardi, Elisa, Nishimura, Kaoru, Han, Ling, Villa, Alessandra, de Sanctis, Daniele, Jovine, Luca

“…Recognition between sperm and the egg surface marks the beginning of life in all sexually reproducing organisms. This fundamental biological event depends on…”
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Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer by Francavilla, Chiara, Lupia, Michela, Tsafou, Kalliopi, Villa, Alessandra, Kowalczyk, Katarzyna, Rakownikow Jersie-Christensen, Rosa, Bertalot, Giovanni, Confalonieri, Stefano, Brunak, Søren, Jensen, Lars J., Cavallaro, Ugo, Olsen, Jesper V.

“…Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a…”
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Localized Axolemma Deformations Suggest Mechanoporation as Axonal Injury Trigger by Montanino, Annaclaudia, Saeedimasine, Marzieh, Villa, Alessandra, Kleiven, Svein

“…Traumatic brain injuries are a leading cause of morbidity and mortality worldwide. With almost 50% of traumatic brain injuries being related to axonal damage,…”
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Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization by Magrini, Elena, Villa, Alessandra, Angiolini, Francesca, Doni, Andrea, Mazzarol, Giovanni, Rudini, Noemi, Maddaluno, Luigi, Komuta, Mina, Topal, Baki, Prenen, Hans, Schachner, Melitta, Confalonieri, Stefano, Dejana, Elisabetta, Bianchi, Fabrizio, Mazzone, Massimiliano, Cavallaro, Ugo

“…While tumor blood vessels share many characteristics with normal vasculature, they also exhibit morphological and functional aberrancies. For example, the…”
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A highly functional synthetic phage display library containing over 40 billion human antibody clones by Weber, Marcel, Bujak, Emil, Putelli, Alessia, Villa, Alessandra, Matasci, Mattia, Gualandi, Laura, Hemmerle, Teresa, Wulhfard, Sarah, Neri, Dario

“…Several synthetic antibody phage display libraries have been created and used for the isolation of human monoclonal antibodies. The performance of antibody…”
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Therapeutic Evaluation of Antibody-Based Targeted Delivery of Interleukin 9 in Experimental Pulmonary Hypertension by Gouyou, Baptiste, Grün, Katja, Kerschenmeyer, Anne, Villa, Alessandra, Matasci, Mattia, Schrepper, Andrea, Pfeil, Alexander, Bäz, Laura, Jung, Christian, Schulze, P Christian, Neri, Dario, Franz, Marcus

“…Pulmonary hypertension (PH) is a heterogeneous disorder associated with poor prognosis. For the majority of patients, only limited therapeutic options are…”
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Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo by Nadal, Lisa, Corbellari, Riccardo, Villa, Alessandra, Weiss, Tobias, Weller, Michael, Neri, Dario, De Luca, Roberto

“…Antibody-based delivery of bioactive molecules represents a promising strategy for the improvement of cancer immunotherapy. Here, we describe the generation…”
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Generation and in vivo characterization of a novel high-affinity human antibody targeting carcinoembryonic antigen by Plüss, Louis, Peissert, Frederik, Elsayed, Abdullah, Rotta, Giulia, Römer, Jonas, Dakhel Plaza, Sheila, Villa, Alessandra, Puca, Emanuele, De Luca, Roberto, Oxenius, Annette, Neri, Dario

“…There are no effective treatment options for most patients with metastatic colorectal cancer (mCRC). mCRC remains a leading cause of tumor-related death, with…”
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Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties by Elsayed, Abdullah, Pellegrino, Christian, Plüss, Louis, Peissert, Frederik, Benz, Ramon, Ulrich, Franziska, Thorhallsdottir, Gudrun, Plaza, Sheila Dakhel, Villa, Alessandra, Mock, Jacqueline, Puca, Emanuele, De Luca, Roberto, Manz, Markus G, Halin, Cornelia, Neri, Dario

“…Antibody-based therapeutics represent an important class of biopharmaceuticals in cancer immunotherapy. CD3 bispecific T-cell engagers activate cytotoxic…”
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LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures by Pabon-Martinez, Y. Vladimir, Xu, You, Villa, Alessandra, Lundin, Karin E., Geny, Sylvain, Nguyen, Chi-Hung, Pedersen, Erik B., Jørgensen, Per T., Wengel, Jesper, Nilsson, Lennart, Smith, C. I. Edvard, Zain, Rula

“…The anti-gene strategy is based on sequence-specific recognition of double-strand DNA by triplex forming (TFOs) or DNA strand invading oligonucleotides to…”
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The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study by Xu, You, Gissberg, Olof, Pabon-Martinez, Y Vladimir, Wengel, Jesper, Lundin, Karin E, Smith, C I Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra

“…Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical…”
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Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier by Saeedimasine, Marzieh, Montanino, Annaclaudia, Kleiven, Svein, Villa, Alessandra

“…Around half of the traumatic brain injuries are thought to be axonal damage. Disruption of the cellular membranes, or alternatively cytoskeletal damage has…”
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New Strategy for the Extension of the Serum Half-Life of Antibody Fragments by Trüssel, Sabrina, Dumelin, Christoph, Frey, Katharina, Villa, Alessandra, Buller, Fabian, Neri, Dario

“…Antibody fragments can recognize their cognate antigen with high affinity and can be produced at high yields, but generally display rapid blood clearance…”
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