Search Results - "VIKIS, Haris"

Principles for the post-GWAS functional characterization of cancer risk loci by Freedman, Matthew L, Monteiro, Alvaro N A, Gayther, Simon A, Coetzee, Gerhard A, Risch, Angela, Plass, Christoph, Casey, Graham, De Biasi, Mariella, Carlson, Chris, Duggan, David, James, Michael, Liu, Pengyuan, Tichelaar, Jay W, Vikis, Haris G, You, Ming, Mills, Ian G

“…Practically, however, it is unclear what the criteria for causality should be, particularly in non-protein-coding regions. [...] although we propose a…”
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CRR9/CLPTM1L Regulates Cell Survival Signaling and Is Required for Ras Transformation and Lung Tumorigenesis by JAMES, Michael A, VIKIS, Haris G, TATE, Everett, RYMASZEWSKI, Amy L, MING YOU

“…The transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer, where it protects tumor cells from genotoxic apoptosis. Here, we show that…”
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RGS17, an Overexpressed Gene in Human Lung and Prostate Cancer, Induces Tumor Cell Proliferation Through the Cyclic AMP-PKA-CREB Pathway by JAMES, Michael A, YAN LU, YAN LIU, VIKIS, Haris G, MING YOU

“…We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of…”
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The role of neutrophil myeloperoxidase in models of lung tumor development by Rymaszewski, Amy L, Tate, Everett, Yimbesalu, Joannes P, Gelman, Andrew E, Jarzembowski, Jason A, Zhang, Hao, Pritchard, Jr, Kirkwood A, Vikis, Haris G

“…Chronic inflammation plays a key tumor-promoting role in lung cancer. Our previous studies in mice demonstrated that neutrophils are critical mediators of…”
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Mechanisms of regulating the Raf kinase family by Chong, Huira, Vikis, Haris G, Guan, Kun-Liang

“…The MAP Kinase pathway is a key signalling mechanism that regulates many cellular functions such as cell growth, transformation and apoptosis. One of the…”
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Real‐world treatment patterns and outcomes in non‐transplant newly diagnosed multiple Myeloma in France, Germany, Italy, and the United Kingdom by Mohty, Mohamad, Knauf, Wolfgang, Romanus, Dorothy, Corman, Shelby, Verleger, Katharina, Kwon, Youngmin, Cherepanov, Dasha, Cambron‐Mellott, M. Janelle, Vikis, Haris G., Gonzalez, Francisco, Gavini, Francois, Ramasamy, Karthik

“…Objectives The treatment paradigm in newly diagnosed multiple myeloma (NDMM) is evolving toward individualized, risk‐directed, and longer duration of therapy…”
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Quantitative monitoring of mouse lung tumors by magnetic resonance imaging by Krupnick, Alexander Sasha, Tidwell, Vanessa K, Engelbach, John A, Alli, Vamsi V, Nehorai, Arye, You, Ming, Vikis, Haris G, Gelman, Andrew E, Kreisel, Daniel, Garbow, Joel R

“…Primary lung cancer remains the leading cause of cancer-related death in the Western world, and the lung is a common site for recurrence of extrathoracic…”
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Activation of FAK and Src are receptor-proximal events required for netrin signaling by Guan, Kun-Liang, Li, Weiquan, Lee, Jeeyong, Vikis, Haris G, Lee, Seung-Hee, Liu, Guofa, Aurandt, Jennifer, Shen, Tang-Long, Fearon, Eric R, Guan, Jun-Lin, Han, Min, Rao, Yi, Hong, Kyonsoo

“…The axon guidance cue netrin is importantly involved in neuronal development. DCC (deleted in colorectal cancer) is a functional receptor for netrin and…”
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Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer by Liu, Pengyuan, Vikis, Haris G., Wang, Daolong, Lu, Yan, Wang, Yian, Schwartz, Ann G., Pinney, Susan M., Yang, Ping, de Andrade, Mariza, Petersen, Gloria M., Wiest, Jonathan S., Fain, Pamela R., Gazdar, Adi, Gaba, Colette, Rothschild, Henry, Mandal, Diptasri, Coons, Teresa, Lee, Juwon, Kupert, Elena, Seminara, Daniela, Minna, John, Bailey-Wilson, Joan E., Wu, Xifeng, Spitz, Margaret R., Eisen, Timothy, Houlston, Richard S., Amos, Christopher I., Anderson, Marshall W., You, Ming

“…Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We…”
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Strain-Specific Variation in Murine Natural Killer Gene Complex Contributes to Differences in Immunosurveillance for Urethane-Induced Lung Cancer by KREISEL, Daniel, GELMAN, Andrew E, TAFFNER, Samantha M, YOKOYAMA, Wayne M, BUI, Jack D, SCHREIBER, Robert D, KRUPNICK, Alexander S, HIGASHIKUBO, Ryuji, XUE LIN, VIKIS, Haris G, MICHAEL WHITE, J, TOTH, Kelsey A, DESHPANDE, Charuhas, CARRENO, Beatriz M, MING YOU

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and results from a complex interaction between carcinogen exposure…”
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The Semaphorin Receptor Plexin-B1 Signals through a Direct Interaction with the Rho-Specific Nucleotide Exchange Factor, LARG by Aurandt, Jennifer, Vikis, Haris G., Gutkind, J. Silvio, Ahn, Natalie, Guan, Kun-Liang

“…Semaphorins are axon guidance molecules that signal through the plexin family of receptors. Semaphorins also play a role in other processes such as immune…”
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Wildtype Kras2 can inhibit lung carcinogenesis in mice by Wang, Yian, You, Ming, Zhang, Zhongqiu, Vikis, Haris G, Johnson, Leisa, Liu, Gongjie, Li, Jie, Anderson, Marshall W, Sills, Robert C, Hong, H.L, Devereux, Theodora R, Jacks, Tyler, Guan, Kun-Liang

“…Although the ras genes have long been established as proto-oncogenes, the dominant role of activated ras in cell transformation has been questioned. Previous…”
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Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis by Vikis, Haris G., Gelman, Andrew E., Franklin, Andrew, Stein, Lauren, Rymaszewski, Amy, Zhu, Jihong, Liu, Pengyuan, Tichelaar, Jay W., Krupnick, Alexander S., You, Ming

“…Multiple studies have shown a link between chronic inflammation and lung tumorigenesis. Inbred mouse strains vary in their susceptibility to methylcholanthrene…”
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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding by Vikis, Haris G, Li, Weiquan, Guan, Kun-Liang

“…The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor…”
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Large-scale in silico mapping of complex quantitative traits in inbred mice by Liu, Pengyuan, Vikis, Haris, Lu, Yan, Wang, Daolong, You, Ming

“…Understanding the genetic basis of common disease and disease-related quantitative traits will aid in the development of diagnostics and therapeutics. The…”
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Mouse models of chemically-induced lung carcinogenesis by Vikis, Haris G, Rymaszewski, Amy L, Tichelaar, Jay W

“…Primary pulmonary malignancies remain the major source of cancer-related deaths in the Western World. While surgical resection is an efficacious therapy for…”
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The Semaphorin Receptor Plexin-B1 Specifically Interacts with Active Rac in a Ligand-Dependent Manner by Vikis, Haris G., Li, Weiquan, He, Zhigang, Guan, Kun-Liang

“…Semaphorin molecules serve as axon guidance signals that regulate the navigation of neuronal growth cones. Semaphorins have also been implicated in other…”
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Regulation of STAT3 by Direct Binding to the Rac1 GTPase by Simon, Amy R., Vikis, Haris G., Stewart, Scott, Fanburg, Barry L., Cochran, Brent H., Guan, Kun-Liang

“…The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after…”
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Glutathione-S-transferase (GST)-fusion based assays for studying protein-protein interactions by Vikis, Haris G, Guan, Kun-Liang

“…Glutathione-S-transferase (GST)-fusion proteins have become an effective reagent to use in the study of protein-protein interactions. GST-fusion proteins can…”
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Cumulative Effect of Multiple Loci on Genetic Susceptibility to Familial Lung Cancer by PENGYUAN LIU, VIKIS, Haris G, MANDAL, Diptasri, LEE, Juwon, KUPERT, Elena, SEMINARA, Daniela, MINNA, John, BAILEY-WILSON, Joan E, AMOS, Christopher I, ANDERSON, Marshall W, MING YOU, YAN LU, YIAN WANG, SCHWARTZ, Ann G, PINNEY, Susan M, PING YANG, DE ANDRADE, Mariza, GAZDAR, Adi, GABA, Colette

“…Genetic factors play important roles in lung cancer susceptibility. In this study, we replicated the association of 5p15.33 and 6p21.33 with familial lung…”
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