Search Results - "VIGNEAULT, Francois"

Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data by Gupta, Namita T, Adams, Kristofor D, Briggs, Adrian W, Timberlake, Sonia C, Vigneault, Francois, Kleinstein, Steven H

“…Adaptive immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to…”
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Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping by Gidoni, Moriah, Snir, Omri, Peres, Ayelet, Polak, Pazit, Lindeman, Ida, Mikocziova, Ivana, Sarna, Vikas Kumar, Lundin, Knut E. A., Clouser, Christopher, Vigneault, Francois, Collins, Andrew M., Sollid, Ludvig M., Yaari, Gur

“…Analysis of antibody repertoires by high-throughput sequencing is of major importance in understanding adaptive immune responses. Our knowledge of variations…”
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pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires by Vander Heiden, Jason A, Yaari, Gur, Uduman, Mohamed, Stern, Joel N H, O'Connor, Kevin C, Hafler, David A, Vigneault, Francois, Kleinstein, Steven H

“…Driven by dramatic technological improvements, large-scale characterization of lymphocyte receptor repertoires via high-throughput sequencing is now feasible…”
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Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing by Vander Heiden, Jason A, Stathopoulos, Panos, Zhou, Julian Q, Chen, Luan, Gilbert, Tamara J, Bolen, Christopher R, Barohn, Richard J, Dimachkie, Mazen M, Ciafaloni, Emma, Broering, Teresa J, Vigneault, Francois, Nowak, Richard J, Kleinstein, Steven H, O'Connor, Kevin C

“…Myasthenia gravis (MG) is a prototypical B cell-mediated autoimmune disease affecting 20-50 people per 100,000. The majority of patients fall into two…”
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Systematic identification of edited microRNAs in the human brain by Alon, Shahar, Mor, Eyal, Vigneault, Francois, Church, George M, Locatelli, Franco, Galeano, Federica, Gallo, Angela, Shomron, Noam, Eisenberg, Eli

“…Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA)…”
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B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes by Stern, Joel N H, Yaari, Gur, Vander Heiden, Jason A, Church, George, Donahue, William F, Hintzen, Rogier Q, Huttner, Anita J, Laman, Jon D, Nagra, Rashed M, Nylander, Alyssa, Pitt, David, Ramanan, Sriram, Siddiqui, Bilal A, Vigneault, Francois, Kleinstein, Steven H, Hafler, David A, O'Connor, Kevin C

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) characterized by autoimmune-mediated demyelination and…”
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Single T Cell Sequencing Demonstrates the Functional Role of αβ TCR Pairing in Cell Lineage and Antigen Specificity by Carter, Jason A, Preall, Jonathan B, Grigaityte, Kristina, Goldfless, Stephen J, Jeffery, Eric, Briggs, Adrian W, Vigneault, Francois, Atwal, Gurinder S

“…Although structural studies of individual T cell receptors (TCRs) have revealed important roles for both the α and β chain in directing MHC and antigen…”
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High-resolution antibody dynamics of vaccine-induced immune responses by Laserson, Uri, Vigneault, Francois, Gadala-Maria, Daniel, Yaari, Gur, Uduman, Mohamed, Heiden, Jason A. Vander, Kelton, William, Jung, Sang Taek, Liu, Yi, Laserson, Jonathan, Chari, Raj, Lee, Je-Hyuk, Bachelet, Ido, Hickey, Brendan, Lieberman-Aiden, Erez, Hanczaruk, Bozena, Simen, Birgitte B., Egholm, Michael, Koller, Daphne, Georgiou, George, Kleinstein, Steven H., Church, George M.

“…The adaptive immune system confers protection by generating a diverse repertoire of antibody receptors that are rapidly expanded and contracted in response to…”
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Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans by Gordin, Miri, Philip, Hagit, Zilberberg, Alona, Gidoni, Moriah, Margalit, Raanan, Clouser, Christopher, Adams, Kristofor, Vigneault, Francois, Cohen, Irun R, Yaari, Gur, Efroni, Sol

“…The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients…”
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Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data by Yaari, Gur, Vander Heiden, Jason A, Uduman, Mohamed, Gadala-Maria, Daniel, Gupta, Namita, Stern, Joel N H, O'Connor, Kevin C, Hafler, David A, Laserson, Uri, Vigneault, Francois, Kleinstein, Steven H

“…Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have…”
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Barcoding bias in high-throughput multiplex sequencing of miRNA by Alon, Shahar, Vigneault, Francois, Eminaga, Seda, Christodoulou, Danos C, Seidman, Jonathan G, Church, George M, Eisenberg, Eli

“…Second-generation sequencing is gradually becoming the method of choice for miRNA detection and expression profiling. Given the relatively small number of…”
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Antibody Repertoire Analysis of Hepatitis C Virus Infections Identifies Immune Signatures Associated With Spontaneous Clearance by Eliyahu, Sivan, Sharabi, Oz, Elmedvi, Shiri, Timor, Reut, Davidovich, Ateret, Vigneault, Francois, Clouser, Chris, Hope, Ronen, Nimer, Assy, Braun, Marius, Weiss, Yaacov Y, Polak, Pazit, Yaari, Gur, Gal-Tanamy, Meital

“…Hepatitis C virus (HCV) is a major public health concern, with over 70 million people infected worldwide, who are at risk for developing life-threatening liver…”
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Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus by Laustsen, Andreas H, Engmark, Mikael, Clouser, Christopher, Timberlake, Sonia, Vigneault, Francois, Gutiérrez, José María, Lomonte, Bruno

“…Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than…”
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Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing by Tsioris, Konstantinos, Gupta, Namita T, Ogunniyi, Adebola O, Zimnisky, Ross M, Qian, Feng, Yao, Yi, Wang, Xiaomei, Stern, Joel N H, Chari, Raj, Briggs, Adrian W, Clouser, Christopher R, Vigneault, Francois, Church, George M, Garcia, Melissa N, Murray, Kristy O, Montgomery, Ruth R, Kleinstein, Steven H, Love, J Christopher

“…West Nile virus (WNV) infection is an emerging mosquito-borne disease that can lead to severe neurological illness and currently has no available treatment or…”
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Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers by VIGNEAULT, Francois, WOODS, Matthew, TELENTI, Amalio, YU, Xu G, LICHTERFELD, Mathias, BUZON, Maria J, CHUN LI, PEREYRA, Florencia, CROSBY, Seth D, RYCHERT, Jennifer, CHURCH, George, MARTINEZ-PICADO, Javier, ROSENBERG, Eric S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Efficient microRNA capture and bar-coding via enzymatic oligonucleotide adenylation by Vigneault, Francois, Church, George M, Sismour, A Michael

“…A simplified strategy to enzymatically preadenylate bar-coded oligonucleotides to be used for capturing microRNAs in biological samples is described. This…”
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Laminin reduces expression of the human α6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3 by GAUDREAULT, Manon, VIGNEAULT, Francois, LECLERC, Steeve, GUERIN, Sylvain L

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Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies by Sok, Devin, Laserson, Uri, Laserson, Jonathan, Liu, Yi, Vigneault, Francois, Julien, Jean-Philippe, Briney, Bryan, Ramos, Alejandra, Saye, Karen F., Le, Khoa, Mahan, Alison, Wang, Shenshen, Kardar, Mehran, Yaari, Gur, Walker, Laura M., Simen, Birgitte B., St. John, Elizabeth P., Chan-Hui, Po-Ying, Swiderek, Kristine, Kleinstein, Stephen H., Alter, Galit, Seaman, Michael S., Chakraborty, Arup K., Koller, Daphne, Wilson, Ian A., Church, George M., Burton, Dennis R., Poignard, Pascal

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Transcriptional regulation of the cyclin-dependent kinase inhibitor 1A (p21) gene by NFI in proliferating human cells by Ouellet, Stéphane, Vigneault, François, Lessard, Maryse, Leclerc, Steeve, Drouin, Régen, Guérin, Sylvain L

“…The cyclin-dependent kinase inhibitor 1A (CDKN1A), also known as p21 (WAF1/CIP1) modulates cell cycle, apoptosis, senescence and differentiation via specific…”
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Liver Is a Generative Site for the B Cell Response to Ehrlichia muris by Trivedi, Nikita, Weisel, Florian, Smita, Shuchi, Joachim, Stephen, Kader, Muhamuda, Radhakrishnan, Aditya, Clouser, Chris, Rosenfeld, Aaron M., Chikina, Maria, Vigneault, Francois, Hershberg, Uri, Ismail, Nahed, Shlomchik, Mark Jay

“…The B cell response to Ehrlichia muris is dominated by plasmablasts (PBs), with few—if any—germinal centers (GCs), yet it generates protective immunoglobulin M…”
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