Search Results - "VIGNALI, Dario A. A"

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups by Andrews, Lawrence P., Yano, Hiroshi, Vignali, Dario A. A.

“…Although immunotherapeutics targeting the inhibitory receptors (IRs) CTLA-4, PD-1 or PD-L1 have made substantial clinical progress in cancer, a considerable…”
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Interferon-γ: teammate or opponent in the tumour microenvironment? by Gocher, Angela M., Workman, Creg J., Vignali, Dario A. A.

“…Cancer immunotherapy offers substantive benefit to patients with various tumour types, in some cases leading to complete tumour clearance. However, many…”
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LAG-3 as the third checkpoint inhibitor by Aggarwal, Vaishali, Workman, Creg J., Vignali, Dario A. A.

“…Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target,…”
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LAG3 (CD223) as a cancer immunotherapy target by Andrews, Lawrence P., Marciscano, Ariel E., Drake, Charles G., Vignali, Dario A. A.

“…Summary Despite the impressive impact of CTLA4 and PD1‐PDL1‐targeted cancer immunotherapy, a large proportion of patients with many tumor types fail to…”
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Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer by Cillo, Anthony R., Kürten, Cornelius H.L., Tabib, Tracy, Qi, Zengbiao, Onkar, Sayali, Wang, Ting, Liu, Angen, Duvvuri, Umamaheswar, Kim, Seungwon, Soose, Ryan J., Oesterreich, Steffi, Chen, Wei, Lafyatis, Robert, Bruno, Tullia C., Ferris, Robert L., Vignali, Dario A.A.

“…Head and neck squamous cell carcinoma (HNSCC) arises through exposure to environmental carcinogens or malignant transformation by human papillomavirus (HPV)…”
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How regulatory T cells work by Vignali, Dario A. A, Collison, Lauren W, Workman, Creg J

“…Key Points Regulatory T (T Reg ) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases…”
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Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion by Sawant, Deepali V., Yano, Hiroshi, Chikina, Maria, Zhang, Qianxia, Liao, Mengting, Liu, Chang, Callahan, Derrick J., Sun, Zhe, Sun, Tao, Tabib, Tracy, Pennathur, Arjun, Corry, David B., Luketich, James D., Lafyatis, Robert, Chen, Wei, Poholek, Amanda C., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T cells (T reg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T reg cells subvert beneficial…”
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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity by Liu, Chang, Somasundaram, Ashwin, Manne, Sasikanth, Gocher, Angela M., Szymczak-Workman, Andrea L., Vignali, Kate M., Scott, Ellen N., Normolle, Daniel P., John Wherry, E., Lipson, Evan J., Ferris, Robert L., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A. A.

“…Robust CD8 + T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory…”
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Once a Treg, always a Treg? by Sawant, Deepali V., Vignali, Dario A. A.

“…Summary Regulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and…”
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Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape by WOO, Seng-Ryong, TURNIS, Meghan E, TANGSOMBATVISIT, Stephanie, GROSSO, Joseph F, NETTO, George, SMELTZER, Matthew P, CHAUX, Alcides, UTZ, Paul J, WORKMAN, Creg J, PARDOLL, Drew M, KORMAN, Alan J, DRAKE, Charles G, GOLDBERG, Monica V, VIGNALI, Dario A. A, BANKOTI, Jaishree, SELBY, Mark, NIRSCHL, Christopher J, BETTINI, Matthew L, GRAVANO, David M, VOGEL, Peter, LONG LIU, Chih

“…Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer. Among these inhibitory receptors, CTLA-4 (targeted clinically by…”
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B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma by Ruffin, Ayana T., Cillo, Anthony R., Tabib, Tracy, Liu, Angen, Onkar, Sayali, Kunning, Sheryl R., Lampenfeld, Caleb, Atiya, Huda I., Abecassis, Irina, Kürten, Cornelius H. L., Qi, Zengbiao, Soose, Ryan, Duvvuri, Umamaheswar, Kim, Seungwon, Oesterrich, Steffi, Lafyatis, Robert, Coffman, Lan G., Ferris, Robert L., Vignali, Dario A. A., Bruno, Tullia C.

“…Current immunotherapy paradigms aim to reinvigorate CD8 + T cells, but the contribution of humoral immunity to antitumor immunity remains understudied. Here,…”
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Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing by Kürten, Cornelius H. L., Kulkarni, Aditi, Cillo, Anthony R., Santos, Patricia M., Roble, Anna K., Onkar, Sayali, Reeder, Carly, Lang, Stephan, Chen, Xueer, Duvvuri, Umamaheswar, Kim, Seungwon, Liu, Angen, Tabib, Tracy, Lafyatis, Robert, Feng, Jian, Gao, Shou-Jiang, Bruno, Tullia C., Vignali, Dario A. A., Lu, Xinghua, Bao, Riyue, Vujanovic, Lazar, Ferris, Robert L.

“…Head and neck squamous cell carcinoma (HNSCC) is characterized by complex relations between stromal, epithelial, and immune cells within the tumor…”
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LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation by Guy, Clifford, Mitrea, Diana M., Chou, Po-Chien, Temirov, Jamshid, Vignali, Kate M., Liu, Xueyan, Zhang, Hui, Kriwacki, Richard, Bruchez, Marcel P., Watkins, Simon C., Workman, Creg J., Vignali, Dario A. A.

“…LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-targeting immunotherapeutics are currently in clinical trials, how…”
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Inhibitory receptors as targets for cancer immunotherapy by Turnis, Meghan E., Andrews, Lawrence P., Vignali, Dario A. A.

“…Inhibitory receptors expressed on T cells control immune responses while limiting autoimmunity. However, tumors can hijack these “checkpoints” for protection…”
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Co-stimulatory and Co-inhibitory Pathways in Autoimmunity by Zhang, Qianxia, Vignali, Dario A.A.

“…The immune system is guided by a series of checks and balances, a major component of which is a large array of co-stimulatory and co-inhibitory pathways that…”
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The inhibitory cytokine IL-35 contributes to regulatory T-cell function by COLLISON, Lauren W, WORKMAN, Creg J, KUO, Timothy T, BOYD, Kelli, YAO WANG, VIGNALI, Kate M, CROSS, Richard, SEHY, David, BLUMBERG, Richard S, VIGNALI, Dario A. A

“…Regulatory T (T(reg)) cells are a critical sub-population of CD4+ T cells that are essential for maintaining self tolerance and preventing autoimmunity, for…”
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Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung by Faustino, Lucas D., Griffith, Jason W., Rahimi, Rod A., Nepal, Keshav, Hamilos, Daniel L., Cho, Josalyn L., Medoff, Benjamin D., Moon, James J., Vignali, Dario A. A., Luster, Andrew D.

“…Foxp3 + regulatory T (T reg ) cells expressing the interleukin (IL)-33 receptor ST2 mediate tissue repair in response to IL-33. Whether T reg cells also…”
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Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3 by Grebinoski, Stephanie, Zhang, Qianxia, Cillo, Anthony R., Manne, Sasikanth, Xiao, Hanxi, Brunazzi, Erin A., Tabib, Tracy, Cardello, Carly, Lian, Christine G., Murphy, George F., Lafyatis, Robert, Wherry, E. John, Das, Jishnu, Workman, Creg J., Vignali, Dario A. A.

“…Impaired chronic viral and tumor clearance has been attributed to CD8 + T cell exhaustion, a differentiation state in which T cells have reduced and altered…”
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Targeting regulatory T cells in tumors by Liu, Chang, Workman, Creg J., Vignali, Dario A. A.

“…Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing autoimmunity. However, they also represent a major barrier to…”
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development and function of regulatory T cells by Workman, Creg J, Szymczak-Workman, Andrea L, Collison, Lauren W, Pillai, Meenu R, Vignali, Dario A. A

“…Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in…”
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