Search Results - "VEXLER, Z. S"

Delayed VEGF Treatment Enhances Angiogenesis and Recovery After Neonatal Focal Rodent Stroke by Dzietko, M., Derugin, N., Wendland, M. F., Vexler, Z. S., Ferriero, D. M.

“…Neonatal stroke occurs in one in 4,000 live births and leads to significant morbidity and mortality. Approximately two thirds of the survivors have long-term…”
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Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke by Fernández-López, D, Faustino, J, Derugin, N, Wendland, M, Lizasoain, I, Moro, M.A, Vexler, Z.S

“…Abstract Cannabinoids have emerged as brain protective agents under neurodegenerative conditions. Many neuroprotective actions of cannabinoids depend on the…”
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Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain by MANABAT, C, HAN, B. H, WENDLAND, M, DERUGIN, N, FOX, C. K, CHOI, J, HOLTZMAN, D. M, FERRIERO, D. M, VEXLER, Z. S

“…Different strategies for neuroprotection of neonatal stroke may be required because the developing brain responds differently to hypoxia-ischemia than the…”
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Echo-planar perfusion-sensitive MR imaging of acute cerebral ischemia by Kucharczyk, J, Vexler, Z S, Roberts, T P, Asgari, H S, Mintorovitch, J, Derugin, N, Watson, A D, Moseley, M E

“…T2*-sensitive echo-planar magnetic resonance imaging was used with first-pass magnetic susceptibility contrast enhancement in a cat model of acute regional…”
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Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy by Arieff, A I, Kozniewska, E, Roberts, T P, Vexler, Z S, Ayus, J C, Kucharczyk, J

“…Children and menstruant women are far more likely than men to develop metabolic brain damage from hyponatremia. We evaluated brain adaptation and mortality…”
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Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling by DONOHOE, P. H, FAHLMAN, C. S, BICKLER, P. E, VEXLER, Z. S, GREGORY, G. A

“…The neuroprotectant fructose-1,6-bisphosphate (FBP) preserves cellular [ATP] and prevents catastrophic increases in [Ca2+]i during hypoxia. Because FBP does…”
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Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals by VEXLER, Z. S, AYUS, J. C, ROBERTS, T. P. L, FRASER, C. L, KUCHARCZYK, J, ARIEFF, A. I

“…Hypoxemia is a major comorbid factor for permanent brain damage in several metabolic encephalopathies. To determine whether hypoxia impairs brain adaptation to…”
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Evaluation of recombinant human basic fibroblast growth factor (rhbFGF) as a cerebroprotective agent using high speed MR imaging by Roberts, T.P.L., Vexler, Z.S., Derugin, N., Kozniewska, E., Kucharczyk, J., Emmett, C.J.

“…The potential cerebroprotective effects of recombinant human basic fibroblast growth factor (rhbFGF) were evaluated in a feline model of acute cerebral…”
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Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model by Derugin, Nikita, Dingman, Andra, Wendland, Michael F., Fox, Christine, Bollen, Andy, Vexler, Zinaida S.

“…Introduction: It is becoming increasingly recognized that CNS immaturity at birth affects ischemic injury and recovery, and that the consequences of neonatal…”
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Modeling Ischemia in the Immature Brain: How Translational Are Animal Models? by Mallard, Carina, Vexler, Zinaida S

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Sensitivity of high-speed "perfusion-sensitive" magnetic resonance imaging to mild cerebral ischemia by Roberts, T P, Vexler, Z S, Vexler, V, Derugin, N, Kucharczyk, J

“…This study assessed the sensitivity of contrast-enhanced dynamic echo-planar imaging to subtotal stenosis of the middle cerebral artery as a model of mildly…”
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Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress by Vexler, Zinaida S., Wong, Arthur, Francisco, Carla, Manabat, Catherine, Christen, Stephan, Täuber, Martin, Ferriero, Donna M., Gregory, George

“…Fructose-1,6-bisphosphate (FBP), an endogenous intermediate of glycolysis, protects the brain against ischemia–reperfusion injury. The mechanisms of FBP…”
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Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats by Derugin, N, Wendland, M, Muramatsu, K, Roberts, T P, Gregory, G, Ferriero, D M, Vexler, Z S

“…Stroke in preterm and term babies is common and results in significant morbidity. The vulnerability and pathophysiological mechanisms of neonatal cerebral…”
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The myth of the immature barrier systems in the developing brain: role in perinatal brain injury by Mallard, Carina, Ek, C. Joakim, Vexler, Zinaida S.

“…Central nervous system homeostasis is maintained by cellular barriers that protect the brain from external environmental changes and protect the CNS from…”
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Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat by Fernández-López, David, Faustino, Joel, Daneman, Richard, Zhou, Lu, Lee, Sarah Y, Derugin, Nikita, Wendland, Michael F, Vexler, Zinaida S

“…The immaturity of the CNS at birth greatly affects injury after stroke but the contribution of the blood-brain barrier (BBB) to the differential response to…”
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Neonatal reversible focal cerebral ischemia: a new model by Derugin, Nikita, Ferriero, Donna M., Vexler, Zinaida S.

“…While numerous animal models exist for studying neonatal brain injury after cerebral ischemia-hypoxia, an adequate model for assessing reversible focal…”
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Viral mimetic triggers cerebral arteriopathy in juvenile brain via neutrophil elastase and NETosis by Rayasam, Aditya, Jullienne, Amandine, Chumak, Tetyana, Faustino, Joel, Szu, Jenny, Hamer, Mary, Ek, C Joakim, Mallard, Carina, Obenaus, Andre, Vexler, Zinaida S

“…Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% of…”
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Scavenger receptor CD36 governs recruitment of myeloid cells to the blood-CSF barrier after stroke in neonatal mice by Rayasam, Aditya, Mottahedin, Amin, Faustino, Joel, Mallard, Carina, Vexler, Zinaida S

“…Ischemic stroke induces the activation and recruitment of peripheral leukocytes to the injured brain. These cells can infiltrate the brain through multiple…”
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Activation of Na+-H+ Exchange Is Necessary for RhoA-induced Stress Fiber Formation by Vexler, Z S, Symons, M, Barber, D L

“…The ubiquitously expressed Na + -H + exchanger isoform, NHE1, functions in regulating intracellular pH and cell volume. We recently determined that the GTPase…”
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Transient cerebral ischemia. Association of apoptosis induction with hypoperfusion by Vexler, Z S, Roberts, T P, Bollen, A W, Derugin, N, Arieff, A I

“…Apoptosis is thought to be important in the pathogenesis of cerebral ischemia. The mechanism of apoptosis induction remains unclear but several studies suggest…”
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