Boar seminal immunosuppressive fraction attenuates the leptin concentration and restores the thymus mass during pregnancy in mice

Boar seminal immunosuppressive fraction attenuates the leptin concentration and restores the thymus mass during pregnancy in mice

The immunosuppressive fraction (ISF) of boar seminal vesicle fluid was recently demonstrated to inhibit production of T helper (Th)1 cytokines and enhance production of Th2 cytokines. The present study shows the effect of the ISF on leptin concentrations in blood plasma and adipose tissue in mice du...

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Bibliographic Details
Published in:Reproduction (Cambridge, England) Vol. 127; no. 5; pp. 581 - 585
Main Authors: VESELSK, L, HOLAN, V, DOSTAL, J, ZELEZNA, B
Format: Journal Article
Language:English
Published: Colchester Society for Reproduction and Fertility 01-05-2004
Portland
Subjects:
Adipose Tissue - chemistry
Animals
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Leptin - analysis
Leptin - blood
Leptin - metabolism
Male
Mammalian male genital system
Mice
Mice, Inbred BALB C
Morphology. Physiology
Organ Size - drug effects
Pregnancy
Pregnancy, Animal - metabolism
Semen - chemistry
Seminal Plasma Proteins - isolation & purification
Seminal Plasma Proteins - pharmacology
Seminal Vesicles - metabolism
Swine
Thymus Gland - anatomy & histology
Vertebrates: reproduction
Pregnancy
Vertebrata
Reproduction
Mammalia
Mouse
Animal
Leptin
Rodentia
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Summary:The immunosuppressive fraction (ISF) of boar seminal vesicle fluid was recently demonstrated to inhibit production of T helper (Th)1 cytokines and enhance production of Th2 cytokines. The present study shows the effect of the ISF on leptin concentrations in blood plasma and adipose tissue in mice during pregnancy. The ISF effect on thymus weight during pregnancy is also demonstrated. The leptin concentration in blood plasma and adipose tissue increased and remained high in the latter half of pregnancy. ISF treatment at the beginning of pregnancy significantly lowered the leptin concentration both in blood plasma and adipose tissue of pregnant mice. Thymus involution has been described previously in pregnant mice. ISF treatment compensated for the loss of thymus mass during the whole pregnancy in the ISF-treated mice. The treatment of pregnant mice with ISF did not affect pregnancy and litter size.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1470-1626
1741-7899
DOI:10.1530/rep.1.00008