Search Results - "VERWOERD, Desiree"

RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1 by Fernandez-Borja, Mar, Janssen, Lennert, Verwoerd, Desiree, Hordijk, Peter, Neefjes, Jacques

“…Rho GTPases are crucial regulators of the actin cytoskeleton and they play a role in the control of membrane trafficking. In contrast to the close family…”
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Recycling MHC Class I Molecules and Endosomal Peptide Loading by Gromme, Monique, Fons G. C. M. Uytdehaag, Janssen, Hans, Calafat, Jero, Van Binnendijk, Robert S., Marcel J. H. Kenter, Tulp, Abraham, Verwoerd, Desiree, Neefjes, Jacques

“…MHC class I molecules usually present peptides derived from endogenous antigens that are bound in the endoplasmic reticulum. Loading of exogenous antigens on…”
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Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor α by Zwart, Wilbert, Griekspoor, Alexander, Rondaij, Mariska, Verwoerd, Desiree, Neefjes, Jacques, Michalides, Rob

“…Anti-estrogen resistance is a major clinical problem in the treatment of breast cancer. In this study, fluorescence resonance energy transfer (FRET) analysis,…”
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Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells by Tan, M C, Mommaas, A M, Drijfhout, J W, Jordens, R, Onderwater, J J, Verwoerd, D, Mulder, A A, van der Heiden, A N, Scheidegger, D, Oomen, L C, Ottenhoff, T H, Tulp, A, Neefjes, J J, Koning, F

“…Dendritic cells (DC) efficiently take up antigens by macropinocytosis and mannose receptor-mediated endocytosis. Here we show that endocytosis of mannose…”
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Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells by BINDELS, Eric M. J, LALLEMAND, Francois, BALKENENDE, Astrid, VERWOERD, Desiree, MICHALIDES, Rob

“…Estrogen receptor-mediated transcription is enhanced by overexpression of G1/S cyclins D1, E or A in the presence as well in the absence of estradiol. Excess…”
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Accumulation of HLA-DM, a Regulator of Antigen Presentation, in MHC Class II Compartments by Sanderson, Frances, Kleijmeer, Monique J., Kelly, Adrian, Verwoerd, Desirée, Tulp, Abraham, Neefjes, Jacques J., Geuze, Hans J., Trowsdale, John

“…The HLA-DM genes encode an unconventional HLA (human leukocyte antigen) class II molecule that is required for appropriate binding of peptide to classical HLA…”
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A Multiradionuclide Automatic Dispensing System for Syringes of Radiopharmaceuticals: The Effect on Operator Hand Dose by Aalbersberg, Else A, Cao, Tammie T, Mylvaganan-Young, Chelvi, Verwoerd, Desiree, Peen, Kirsten, Sonneborn-Bols, Mariska, Hendrikx, Jeroen J M A

“…The radiation exposure of the hands of nuclear medicine laboratory technicians is largely due to the dispensing of radiopharmaceuticals into syringes. To…”
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Occupational Radiation Exposure of Radiopharmacy, Nuclear Medicine, and Surgical Personnel During Use of [ 99m Tc]Tc-PSMA-I&S for Prostate Cancer Surgery by Aalbersberg, Else A, Verwoerd, Desiree, Mylvaganan-Young, Chelvi, de Barros, Hilda A, van Leeuwen, Pim J, Sonneborn-Bols, Mariska, Donswijk, Maarten L

“…The aim of this study was to estimate and subsequently measure the occupational radiation exposure for all personnel involved in producing, administering, or…”
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Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen by Houtman, René, de Leeuw, Renée, Rondaij, Mariska, Melchers, Diana, Verwoerd, Desiree, Ruijtenbeek, Rob, Martens, John W M, Neefjes, Jacques, Michalides, Rob

“…With current techniques, it remains a challenge to assess coregulator binding of nuclear receptors, for example, the estrogen receptor alpha (ERα). ERα is…”
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Tamoxifen resistance by a conformational arrest of the estrogen receptor α after PKA activation in breast cancer by Michalides, Rob, Griekspoor, Alexander, Balkenende, Astrid, Verwoerd, Desiree, Janssen, Lennert, Jalink, Kees, Floore, Arno, Velds, Arno, van `t Veer, Laura, Neefjes, Jacques

“…Using a novel approach that detects changes in the conformation of ERα, we studied the efficacy of anti-estrogens to inactivate ERα under different…”
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Direct Vesicular Transport of MHC Class II Molecules from Lysosomal Structures to the Cell Surface by Wubbolts, Richard, Fernandez-Borja, Mar, Oomen, Lauran, Verwoerd, Desiree, Janssen, Hans, Calafat, Jero, Tulp, Abraham, Dusseljee, Simone, Neefjes, Jacques

“…Newly synthesized MHC class II molecules are sorted to lysosomal structures where peptide loading can occur. Beyond this point in biosynthesis, no MHC class II…”
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Electromigration for separations of protein complexes by Tulp, Ab, Verwoerd, Désirée, Neefjes, Jacques

“…This paper describes electromigration of complexes, consisting of two or more proteins and non-covalently associated peptides. Relatively small complexes ( M…”
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Regulation of MHC Class II Antigen Presentation by Sorting of Recycling HLA-DM/DO and Class II within the Multivesicular Body by van Lith, Marcel, van Ham, Marieke, Griekspoor, Alexander, Tjin, Esther, Verwoerd, Desiree, Calafat, Jero, Janssen, Hans, Reits, Eric, Pastoors, Liesbeth, Neefjes, Jacques

“…MHC class II molecules bind antigenic peptides in the late endosomal/lysosomal MHC class II compartments (MIIC) before cell surface presentation. The class II…”
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High-resolution density gradient electrophoresis of proteins and subcellular organelles by Tulp, A, Verwoerd, D, Benham, A, Neefjes, J

“…Following a concept developed by Bier et al. (Electrophoresis 1993, 14, 1011-1018), binary mixtures of amphoteric buffers with low conductivity and a good…”
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Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA by Dusseljee, S, Wubbolts, R, Verwoerd, D, Tulp, A, Janssen, H, Calafat, J, Neefjes, J

“…We have studied the degradation of the free major histocompatibility complex (MHC) class II beta subunit in the ER. Domain swapping experiments demonstrate…”
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Lectin-induced retardation of subcellular organelles during preparative density gradient electrophoresis: Selective purification of plasma membranes by Tulp†, Abraham, Verwoerd, Desiree, Neefjes, Jacques

“…Plasma membranes (PM) are difficult to separate by conventional means from other cellular compartments. Using a density gradient electrophoresis (DGE)…”
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HLA-DM and MHC class II molecules co-distribute with peptidase-containing lysosomal subcompartments by Fernandez-Borja, Mar, Verwoerd, Desiree, Sanderson, Frances, Aerts, Hans, Trowsdale, John, Tulp, Abraham, Neefjes, Jacques

“…MHC class II molecules associate with peptides in the endocytic pathway. Different endosomal locations for peptide loading of class II molecules, varying from…”
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Removal and degradation of the free MHC class II p chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA by Dusseljee, Simone, Wubbolts, Richard, Verwoerd, Desiree, Tulp, Abraham, Janssen, Hans, Calafat, Jero, Neefjes, Jacques

“…We have studied the degradation of the free major histocompatibility complex (MHC) class II β subunit in the ER. Domain swapping experiments demonstrate that…”
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Isolation and characterization of the intracellular MHC class II compartment by Tulp, Abraham, Verwoerd, Desirée, Dobberstein, Bernhard, Ploegh, Hidde L, Pieters, Jean

“…An intracellular compartment has been isolated to which MHC class II molecules are transported on their way to the plasma membrane. They arrive with an…”
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Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells by Tan, M C, Mommaas, A M, Drijfhout, J W, Jordens, R, Onderwater, J J, Verwoerd, D, Mulder, A A, van der Heiden, A N, Ottenhoff, T H, Cella, M, Tulp, A, Neefjes, J J, Koning, F

“…Dendritic cells (DCs) use macropinocytosis and mannose receptor mediated endocytosis for the uptake of exogenous antigens. Here we show that the endocytosis of…”
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