Search Results - "VERSTEEG, Gijs A"

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity by Rajsbaum, Ricardo, García-Sastre, Adolfo, Versteeg, Gijs A.

“…Tripartite motif (TRIM) proteins have been implicated in multiple cellular functions, including antiviral activity. Research efforts so far indicate that the…”
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The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors by Versteeg, Gijs A., Rajsbaum, Ricardo, Sánchez-Aparicio, Maria Teresa, Maestre, Ana M., Valdiviezo, Julio, Shi, Mude, Inn, Kyung-Soo, Fernandez-Sesma, Ana, Jung, Jae, García-Sastre, Adolfo

“…Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins have…”
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Viral tricks to grid-lock the type I interferon system by Versteeg, Gijs A, García-Sastre, Adolfo

“…Type I interferons (IFNs) play a crucial role in the innate immune avant-garde against viral infections. Virtually all viruses have developed means to…”
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InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins by Versteeg, Gijs A, Benke, Stefan, García-Sastre, Adolfo, Rajsbaum, Ricardo

“…Abstract During the immune response, striking the right balance between positive and negative regulation is critical to effectively mount an anti-microbial…”
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Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein by Rajsbaum, Ricardo, Albrecht, Randy A, Wang, May K, Maharaj, Natalya P, Versteeg, Gijs A, Nistal-Villán, Estanislao, García-Sastre, Adolfo, Gack, Michaela U

“…Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses…”
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Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination by Budroni, Valentina, Versteeg, Gijs A

“…The rapid and dynamic activation of the innate immune system is achieved through complex signaling networks regulated by post-translational modifications…”
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Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response by Rajsbaum, Ricardo, Versteeg, Gijs A., Schmid, Sonja, Maestre, Ana M., Belicha-Villanueva, Alan, Martínez-Romero, Carles, Patel, Jenish R., Morrison, Juliet, Pisanelli, Giuseppe, Miorin, Lisa, Laurent-Rolle, Maudry, Moulton, Hong M., Stein, David A., Fernandez-Sesma, Ana, tenOever, Benjamin R., García-Sastre, Adolfo

“…Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of…”
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HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells by Oudshoorn, Diede, van Boheemen, Sander, Sánchez-Aparicio, Maria Teresa, Rajsbaum, Ricardo, García-Sastre, Adolfo, Versteeg, Gijs A

“…Type I interferon (IFN) stimulates expression and conjugation of the ubiquitin-like modifier IFN-stimulated gene 15 (ISG15), thereby restricting replication of…”
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HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation by Scinicariello, Sara, Soderholm, Adrian, Schäfer, Markus, Shulkina, Alexandra, Schwartz, Irene, Hacker, Kathrin, Gogova, Rebeca, Kalis, Robert, Froussios, Kimon, Budroni, Valentina, Bestehorn, Annika, Clausen, Tim, Kovarik, Pavel, Zuber, Johannes, Versteeg, Gijs A

“…Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory…”
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Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner by Watzenboeck, Martin L, Drobits, Barbara, Zahalka, Sophie, Gorki, Anna-Dorothea, Farhat, Asma, Quattrone, Federica, Hladik, Anastasiya, Lakovits, Karin, Richard, Gabriel M, Lederer, Therese, Strobl, Birgit, Versteeg, Gijs A, Boon, Louis, Starkl, Philipp, Knapp, Sylvia

“…Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron…”
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Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers by Oudshoorn, Diede, Versteeg, Gijs A, Kikkert, Marjolein

“…Abstract Detection of invading pathogens by pattern recognition receptors (PRRs) is crucial for the activation of the innate immune response. These sensors…”
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SPOP targets the immune transcription factor IRF1 for proteasomal degradation by Schwartz, Irene, Vunjak, Milica, Budroni, Valentina, Cantoran García, Adriana, Mastrovito, Marialaura, Soderholm, Adrian, Hinterndorfer, Matthias, de Almeida, Melanie, Hacker, Kathrin, Wang, Jingkui, Froussios, Kimon, Jude, Julian, Decker, Thomas, Zuber, Johannes, Versteeg, Gijs A

“…Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after…”
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Ubiquitin enzymes in the regulation of immune responses by Ebner, Petra, Versteeg, Gijs A, Ikeda, Fumiyo

“…Ubiquitination plays a central role in the regulation of various biological functions including immune responses. Ubiquitination is induced by a cascade of…”
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Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein by VERSTEEG, Gijs A, HALE, Benjamin G, VAN BOHEEMEN, Sander, WOLFF, Thorsten, LENSCHOW, Deborah J, GARCIA-SASTRE, Adolfo

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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor by Mata, Miguel A, Satterly, Neal, Versteeg, Gijs A, Frantz, Doug, Wei, Shuguang, Williams, Noelle, Schmolke, Mirco, Peña-Llopis, Samuel, Brugarolas, James, Forst, Christian V, White, Michael A, García-Sastre, Adolfo, Roth, Michael G, Fontoura, Beatriz M A

“…A screen for compounds that alleviate the inhibitory effect of influenza NS1 on host gene expression and suppress viral toxicity found naphthalimides that…”
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TRIM proteins by Vunjak, Milica, Versteeg, Gijs A.

“…Vunjak and Versteeg introduce the TRIM family of post-translational modifiers and the roles of these proteins in viral restriction, immune signaling and…”
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The Coronavirus Spike Protein Induces Endoplasmic Reticulum Stress and Upregulation of Intracellular Chemokine mRNA Concentrations by VERSTEEG, Gijs A, VAN DE NES, Paula S, BREDENBEEK, Peter J, SPAAN, Willy J. M

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates by de Almeida, Melanie, Hinterndorfer, Matthias, Brunner, Hanna, Grishkovskaya, Irina, Singh, Kashish, Schleiffer, Alexander, Jude, Julian, Deswal, Sumit, Kalis, Robert, Vunjak, Milica, Lendl, Thomas, Imre, Richard, Roitinger, Elisabeth, Neumann, Tobias, Kandolf, Susanne, Schutzbier, Michael, Mechtler, Karl, Versteeg, Gijs A., Haselbach, David, Zuber, Johannes

“…Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable…”
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Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex by Ehrmann, Julian F, Grabarczyk, Daniel B, Heinke, Maria, Deszcz, Luiza, Kurzbauer, Robert, Hudecz, Otto, Shulkina, Alexandra, Gogova, Rebeca, Meinhart, Anton, Versteeg, Gijs A, Clausen, Tim

“…Inhibitor of apoptosis proteins (IAPs) bind to pro-apoptotic proteases, keeping them inactive and preventing cell death. The atypical ubiquitin ligase BIRC6 is…”
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Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced clustering by Kettel, Paulina, Marosits, Laura, Spinetti, Elena, Rechberger, Michael, Giannini, Caterina, Radler, Philipp, Niedermoser, Isabell, Fischer, Irmgard, Versteeg, Gijs A, Loose, Martin, Covino, Roberto, Karagöz, G Elif

“…Conserved signaling cascades monitor protein-folding homeostasis to ensure proper cellular function. One of the evolutionary conserved key players is IRE1,…”
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