Search Results - "VERRELLE, Pierre"

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting by Biau, Julian, Chautard, Emmanuel, Verrelle, Pierre, Dutreix, Marie

“…Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer…”
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Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System by Patriarca, Annalisa, Fouillade, Charles, Auger, Michel, Martin, Frédéric, Pouzoulet, Frédéric, Nauraye, Catherine, Heinrich, Sophie, Favaudon, Vincent, Meyroneinc, Samuel, Dendale, Rémi, Mazal, Alejandro, Poortmans, Philip, Verrelle, Pierre, De Marzi, Ludovic

“…Recent in vivo investigations have shown that short pulses of electrons at very high dose rates (FLASH) are less harmful to healthy tissues but just as…”
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FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence by Fouillade, Charles, Curras-Alonso, Sandra, Giuranno, Lorena, Quelennec, Eddy, Heinrich, Sophie, Bonnet-Boissinot, Sarah, Beddok, Arnaud, Leboucher, Sophie, Karakurt, Hamza Umut, Bohec, Mylène, Baulande, Sylvain, Vooijs, Marc, Verrelle, Pierre, Dutreix, Marie, Londoño-Vallejo, Arturo, Favaudon, Vincent

“…One of the main limitations to anticancer radiotherapy lies in irreversible damage to healthy tissues located within the radiation field. "FLASH" irradiation…”
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Significant correlation between gross tumor volume (GTV) D98% and local control in multifraction stereotactic radiotherapy (MF-SRT) for unresected brain metastases by Dupic, Guillaume, Brun, Lucie, Molnar, Ioana, Leyrat, Brice, Chassin, Vincent, Moreau, Juliette, Dedieu, Véronique, Khalil, Toufic, Verrelle, Pierre, Lapeyre, Michel, Biau, Julian

“…•Monocentric study on brain multifraction SRT using the ICRU 91 reporting standards.•Explicit reporting of PTV and GTV Dmin, D98%, D50%, D2%, Dmax, Dmin,…”
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Second course of stereotactic radiosurgery for locally recurrent brain metastases: Safety and efficacy by Moreau, Juliette, Khalil, Toufic, Dupic, Guillaume, Chautard, Emmanuel, Lemaire, Jean-Jacques, Magnier, Florian, Dedieu, Véronique, Lapeyre, Michel, Verrelle, Pierre, Biau, Julian

“…In the present study, we have evaluated the efficacy and toxicity of repeated brain metastases (BM) stereotactic radiosurgery (SRS2) following local failure of…”
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The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation by Le Boiteux, Elisa, Guichet, Pierre-Olivier, Masliantsev, Konstantin, Montibus, Bertille, Vaurs-Barriere, Catherine, Gonthier-Gueret, Céline, Chautard, Emmanuel, Verrelle, Pierre, Karayan-Tapon, Lucie, Fogli, Anne, Court, Franck, Arnaud, Philippe

“…Glioblastomas represent approximatively half of all gliomas and are the most deadly and aggressive form. Their therapeutic resistance and tumor relapse rely on…”
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Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation by Silina, Linda, Dufour, Florent, Rapinat, Audrey, Reyes, Cécile, Gentien, David, Maksut, Fatlinda, Radvanyi, François, Verrelle, Pierre, Bernard-Pierrot, Isabelle, Mégnin-Chanet, Frédérique

“…Bladder cancer is a common cancer; it is the tenth most common cancer in the world. Around one fourth of all diagnosed patients have muscle-invasive bladder…”
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Preoperative stereotactic radiosurgery for brain metastases: the STEP study protocol for a multicentre, prospective, phase-II trial by Ginzac, Angeline, Dupic, Guillaume, Brun, Lucie, Molnar, Ioana, Casile, Mélanie, Durando, Xavier, Verrelle, Pierre, Lemaire, Jean-Jacques, Khalil, Toufic, Biau, Julian

“…Background Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and…”
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Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage by Le Boiteux, Elisa, Court, Franck, Guichet, Pierre‐Olivier, Vaurs‐Barrière, Catherine, Vaillant, Isabelle, Chautard, Emmanuel, Verrelle, Pierre, Costa, Bruno M., Karayan‐Tapon, Lucie, Fogli, Anne, Arnaud, Philippe

“…In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly…”
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A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes by Foy, Jean-Philippe, Bazire, Louis, Ortiz-Cuaran, Sandra, Deneuve, Sophie, Kielbassa, Janice, Thomas, Emilie, Viari, Alain, Puisieux, Alain, Goudot, Patrick, Bertolus, Chloé, Foray, Nicolas, Kirova, Youlia, Verrelle, Pierre, Saintigny, Pierre

“…Radiotherapy for head and neck squamous cell carcinomas (HNSCC) is associated with a substantial morbidity and inconsistent efficacy. Human papillomavirus…”
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Outcome of giant pituitary tumors requiring surgery by Gaillard, Stephan, Adeniran, Sosthène, Villa, Chiara, Jouinot, Anne, Raffin-Sanson, Marie-Laure, Feuvret, Loic, Verrelle, Pierre, Bonnet, Fidéline, Dohan, Anthony, Bertherat, Jérôme, Assié, Guillaume, Baussart, Bertrand

“…ObjectiveThe management of giant pituitary tumors is complex, with few publications and recommendations. Consequently, patient's care mainly relies on clinical…”
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NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells by Loubeau, Gaëlle, Boudra, Rafik, Maquaire, Sabrina, Lours-Calet, Corinne, Beaudoin, Claude, Verrelle, Pierre, Morel, Laurent

“…The chaperone nucleophosmin (NPM1) is over-expressed in the epithelial compartment of prostate tumours compared to adjacent healthy epithelium and may…”
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Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models by Biau, Julian, Chautard, Emmanuel, Berthault, Nathalie, de Koning, Leanne, Court, Frank, Pereira, Bruno, Verrelle, Pierre, Dutreix, Marie

“…High grade glioma relapses occur often within the irradiated volume mostly due to a high resistance to radiation therapy (RT). Dbait (which stands for DNA…”
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Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis by Fogli, Anne, Demattei, Marie-Véronique, Corset, Laetitia, Vaurs-Barrière, Catherine, Chautard, Emmanuel, Biau, Julian, Kémény, Jean-Louis, Godfraind, Catherine, Pereira, Bruno, Khalil, Toufik, Grandin, Nathalie, Arnaud, Philippe, Charbonneau, Michel, Verrelle, Pierre

“…Human malignant gliomas exhibit acquisition of either one of two telomere maintenance mechanisms, resulting from either reactivation of telomerase expression…”
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DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects by El Ouadih, Youssef, Pereira, Bruno, Biau, Julian, Claise, Béatrice, Chaix, Rémi, Verrelle, Pierre, Khalil, Toufik, Durando, Xavier, Lemaire, Jean-Jacques

“…(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these…”
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A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma by Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie

“…Abstract Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break…”
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Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound by Merle, Patrick, Gueugneau, Marine, Teulade-Fichou, Marie-Paule, Müller-Barthélémy, Mélanie, Amiard, Simon, Chautard, Emmanuel, Guetta, Corinne, Dedieu, Véronique, Communal, Yves, Mergny, Jean-Louis, Gallego, Maria, White, Charles, Verrelle, Pierre, Tchirkov, Andreï

“…Telomeres are nucleoprotein structures at the end of chromosomes which stabilize and protect them from nucleotidic degradation and end-to-end fusions. The…”
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Stereotactic Radiosurgery for Vestibular Schwannomas: Reducing Toxicity With 11 Gy as the Marginal Prescribed Dose by Dupic, Guillaume, Urcissin, Marie, Mom, Thierry, Verrelle, Pierre, Dedieu, Véronique, Molnar, Ioana, El-Ouadih, Youssef, Chassin, Vincent, Lapeyre, Michel, Lemaire, Jean-Jacques, Biau, Julian, Khalil, Toufic

“…Stereotactic radiosurgery (SRS) is a common treatment option for vestibular schwannomas. Historically, a dose de-escalation of the marginal prescribed dose…”
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CENP-A Subnuclear Localization Pattern as Marker Predicting Curability by Chemoradiation Therapy for Locally Advanced Head and Neck Cancer Patients by Verrelle, Pierre, Meseure, Didier, Berger, Frédérique, Forest, Audrey, Leclère, Renaud, Nicolas, André, Fortas, Emilie, Sastre-Garau, Xavier, Lae, Marick, Boudjemaa, Sabah, Mbagui, Rodrigue, Calugaru, Valentin, Labiod, Dalila, De Koning, Leanne, Almouzni, Geneviève, Quivy, Jean-Pierre

“…Effective biomarkers predictive of the response to treatments are key for precision medicine. This study identifies the staining pattern of the centromeric…”
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Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma by Biau, Julian, Chautard, Emmanuel, De Koning, Leanne, Court, Frank, Pereira, Bruno, Verrelle, Pierre, Dutreix, Marie

“…Radiotherapy plays a major role in the management of high grade glioma. However, the radioresistance of glioma cells limits its efficiency and drives…”
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