Search Results - "VERRECCHIA, Franck"

Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment by Verrecchia, Franck, Rédini, Françoise

“…Osteosarcomas are the most frequent form of primary bone tumors and mainly affect children, adolescents, and young adults. Despite encouraging progress in…”
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Transforming growth factor-beta and fibrosis by Verrecchia, Franck, Mauviel, Alain

“…Transforming growth factor-beta (TGF-beta), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling…”
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The Osteosarcoma Microenvironment: A Complex But Targetable Ecosystem by Corre, Isabelle, Verrecchia, Franck, Crenn, Vincent, Redini, Francoise, Trichet, Valérie

“…Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in…”
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New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies? by Danieau, Geoffroy, Morice, Sarah, Rédini, Françoise, Verrecchia, Franck, Royer, Bénédicte Brounais-Le

“…Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors mainly occurring in children, adolescents and young adults. Current standard…”
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Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma by Lamora, Audrey, Talbot, Julie, Bougras, Gwenola, Amiaud, Jérôme, Leduc, Marion, Chesneau, Julie, Taurelle, Julien, Stresing, Verena, Le Deley, Marie Cécile, Heymann, Marie Françoise, Heymann, Dominique, Redini, Françoise, Verrecchia, Franck

“…Osteosarcoma is the main malignant primary bone tumor in children and adolescents for whom the prognosis remains poor, especially when metastasis is present at…”
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Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts by Chemel, Marguerite, Brion, Regis, Segaliny, Aude-Isabelle, Lamora, Audrey, Charrier, Celine, Brulin, Benedicte, Maugars, Yves, Le Goff, Benoit, Heymann, Dominique, Verrecchia, Franck

“…IL-34 is a proinflammatory cytokine implicated in rheumatoid arthritis (RA). The current study aimed to assess the IL-34 expression in response to two members…”
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Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification by Espitia, Olivier, Chatelais, Mathias, Steenman, Marja, Charrier, Céline, Maurel, Blandine, Georges, Steven, Houlgatte, Rémi, Verrecchia, Franck, Ory, Benjamin, Lamoureux, François, Heymann, Dominique, Gouëffic, Yann, Quillard, Thibaut

“…Vascular calcification is a strong and independent predictive factor for cardiovascular complications and mortality. Our previous work identified important…”
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Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases by Lamora, Audrey, Mullard, Mathilde, Amiaud, Jérôme, Brion, Régis, Heymann, Dominique, Redini, Françoise, Verrecchia, Franck

“…Osteosarcoma is the main malignant primary bone tumor in children and adolescents for whom the prognosis remains poor, especially when metastases are present…”
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GLI2-Mediated Melanoma Invasion and Metastasis by Alexaki, Vasileia-Ismini, Javelaud, Delphine, Van Kempen, Leon C. L., Mohammad, Khalid S., Dennler, Sylviane, Luciani, Flavie, Hoek, Keith S., Juàrez, Patricia, Goydos, James S., Fournier, Pierrick J., Sibon, Claire, Bertolotto, Corine, Verrecchia, Franck, Saule, Simon, Delmas, Veronique, Ballotti, Robert, Larue, Lionel, Saiag, Philippe, Guise, Theresa A., Mauviel, Alain

“…Background The transforming growth factor-β (TGF-β) pathway, which has both tumor suppressor and pro-oncogenic activities, is often constitutively active in…”
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Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis by Morice, Sarah, Danieau, Geoffroy, Tesfaye, Robel, Mullard, Mathilde, Brion, Régis, Dupuy, Maryne, Ory, Benjamin, Brounais-Le Royer, Bénédicte, Corre, Isabelle, Redini, Françoise, Verrecchia, Franck

“…The poor survival rate of patients with osteosarcoma (OS), specifically with metastases at diagnosis, undergoes the urgency to develop new therapeutic…”
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Molecular Chaperones in Osteosarcoma: Diagnosis and Therapeutic Issues by Lallier, Morgane, Marchandet, Louise, Moukengue, Brice, Charrier, Celine, Baud'huin, Marc, Verrecchia, Franck, Ory, Benjamin, Lamoureux, François

“…Osteosarcoma (OS) is the most common form of primary bone tumor affecting mainly children and young adults. Despite therapeutic progress, the 5-year survival…”
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SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression by Lézot, Frédéric, Corre, Isabelle, Morice, Sarah, Rédini, Françoise, Verrecchia, Franck

“…Primary bone tumors can be divided into two classes, benign and malignant. Among the latter group, osteosarcoma and Ewing sarcoma are the most prevalent…”
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Antagonistic Functions of Connexin 43 during the Development of Primary or Secondary Bone Tumors by Talbot, Julie, Dupuy, Maryne, Morice, Sarah, Rédini, Françoise, Verrecchia, Franck

“…Despite research and clinical advances during recent decades, bone cancers remain a leading cause of death worldwide. There is a low survival rate for patients…”
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LIM Kinases in Osteosarcoma Development by Brion, Régis, Regnier, Laura, Mullard, Mathilde, Amiaud, Jérome, Rédini, Françoise, Verrecchia, Franck

“…Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear…”
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In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil by Roos, Nina, Poulalhon, Nicolas, Farge, Dominique, Madelaine, Isabelle, Mauviel, Alain, Verrecchia, Franck

“…The immunosuppressive drug mycophenolate mofetil (MMF) is used to prevent organ rejection after transplantation and has shown some efficacy to prevent the…”
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ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells by Danieau, Geoffroy, Morice, Sarah, Renault, Sarah, Brion, Régis, Biteau, Kevin, Amiaud, Jérôme, Cadé, Marie, Heymann, Dominique, Lézot, Frédéric, Verrecchia, Franck, Rédini, Françoise, Brounais-Le Royer, Bénédicte

“…High-grade osteosarcomas are the most frequent malignant bone tumors in the pediatric population, with 150 patients diagnosed every year in France…”
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Ewing sarcoma from molecular biology to the clinic by Dupuy, Maryne, Lamoureux, François, Mullard, Mathilde, Postec, Anaïs, Regnier, Laura, Baud’huin, Marc, Georges, Steven, Brounais-Le Royer, Bénédicte, Ory, Benjamin, Rédini, Françoise, Verrecchia, Franck

“…In Europe, with an incidence of 7.5 cases per million, Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children, adolescents and…”
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Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619 by Lavaud, Mélanie, Mullard, Mathilde, Tesfaye, Robel, Amiaud, Jérôme, Legrand, Mélanie, Danieau, Geoffroy, Brion, Régis, Morice, Sarah, Regnier, Laura, Dupuy, Maryne, Brounais-Le Royer, Bénédicte, Lamoureux, François, Ory, Benjamin, Rédini, Françoise, Verrecchia, Franck

“…Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of…”
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Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling by FERRIGNO, Olivier, LALLEMAND, Francois, VERRECCHIA, Franck, L'HOSTE, Sébastien, CAMONIS, Jacques, ATFI, Azeddine, MAUVIEL, Alain

“…Members of the TGF-beta family of growth factors signal from the cell surface through serine/threonine kinase receptors. Intracellular propagation of the…”
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Disruption of Basal JNK Activity Differentially Affects Key Fibroblast Functions Important for Wound Healing by Javelaud, Delphine, Laboureau, Julien, Gabison, Eric, Verrecchia, Franck, Mauviel, Alain

“…We used both a gene knockout approach and pharmacologic modulation to study the implication of the JNK pathway in regulating fibroblast motility, capacity to…”
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