Search Results - "VERNOLE, Patrizia"

PARP-1 modulates amyloid beta peptide-induced neuronal damage by Martire, Sara, Fuso, Andrea, Rotili, Dante, Tempera, Italo, Giordano, Cesare, De Zottis, Ivana, Muzi, Alessia, Vernole, Patrizia, Graziani, Grazia, Lococo, Emanuela, Faraldi, Martina, Maras, Bruno, Scarpa, Sigfrido, Mosca, Luciana, d'Erme, Maria

“…Amyloid beta peptide (Aβ) causes neurodegeneration by several mechanisms including oxidative stress, which is known to induce DNA damage with the consequent…”
Get full text

FLASH and NPAT positive but not Coilin positive Cajal bodies correlate with cell ploidy by Bongiorno-Borbone, Lucilla, De Cola, Antonella, Vernole, Patrizia, Finos, Livio, Barcaroli, Daniela, Knight, Richard A., Melino, Gerry, De Laurenzi, Vincenzo

“…Cajal Bodies are one of many specialised organelles contained in the eukaryotic cell nucleus, and are involved in a number of functions, including regulation…”
Get full text

TAp73α binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy by Vernole, Patrizia, Neale, Michael H., Barcaroli, Daniela, Munarriz, Eliana, Knight, Richard, Tomasini, Richard, Mak, Tak W., Melino, Gerry, De Laurenzi, Vincenzo

“…Aneuploidy is a characteristic of most solid tumors, often associated with negative prognosis. It can arise from two principal mechanisms: from a tetraploid…”
Get full text

Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin by Vernole, Patrizia, Tedeschi, Bruna, Tentori, Lucio, Levati, Lauretta, Argentin, Gabriella, Cicchetti, Rosadele, Forini, Olindo, Graziani, Grazia, D'Atri, Stefania

“…The mismatch repair (MMR) system and p53 protein play a pivotal role in maintaining genomic stability and modulate cell chemosensitivity. Aim of this study was…”
Get more information

The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma by Tentori, Lucio, Dorio, Annalisa Susanna, Mazzon, Emanuela, Muzi, Alessia, Sau, Andrea, Cuzzocrea, Salvatore, Vernole, Patrizia, Federici, Giorgio, Caccuri, Anna Maria, Graziani, Grazia

“…Abstract First line treatment of metastatic melanoma includes the methylating agent dacarbazine or its analogue temozolomide (TMZ) with improved…”
Get full text

MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination by Tentori, Lucio, Muzi, Alessia, Dorio, Annalisa Susanna, Dolci, Susanna, Campolo, Federica, Vernole, Patrizia, Lacal, Pedro Miguel, Praz, Françoise, Graziani, Grazia

“…Purpose Defective expression of the mismatch repair protein MSH3 is frequently detected in colon cancer, and down-regulation of its expression was found to…”
Get full text

Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan by TENTORI, LUCIO, LEONETTI, CARLO, MUZI, ALESSIA, DORIO, ANNALISA SUSANNA, PORRU, MANUELA, DOLCI, SUSANNA, CAMPOLO, FEDERICA, VERNOLE, PATRIZIA, LACAL, PEDRO MIGUEL, PRAZ, FRANÇOISE, GRAZIANI, GRAZIA

“…Poly(ADP-ribose) polymerase inhibitors (PARPi) are currently evaluated in clinical trials in combination with topoisomerase I (Top1) inhibitors against a…”
Get full text

Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells by Vernole, Patrizia, Muzi, Alessia, Volpi, Antonio, Dorio, Annalisa S, Terrinoni, Alessandro, Shah, Girish M, Graziani, Grazia

“…Mismatch repair (MMR) has been shown to control homologous recombination (HR) by aborting strand exchange between divergent sequences. We previously…”
Get more information

Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents by VERNOLE, Patrizia, PEPPONI, Rita, D'ATRI, Stefania

“…The mismatch repair (MMR) system plays a major role in mediating the cytotoxicity and clastogenicity of agents generating O(6)-methylguanine in DNA. Loss of…”
Get full text

Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs by Tentori, Lucio, Vergati, Matteo, Muzi, Alessia, Levati, Lauretta, Ruffini, Federica, Forini, Olindo, Vernole, Patrizia, Lacal, Pedro Miguel, Graziani, Grazia

“…Assessment of chemosensitivity of neovessel endo-thelium associated to tumor mass is hindered by the limited availability of experimental models of actively…”
Get more information

Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes by TENTORI, Lucio, PORTARENA, Ilaria, VERNOLE, Patrizia, GOLD, Barry, GRAZIANI, Grazia

“…Selective N3-adenine methylation represents a novel strategy for tumors with a phenotype of poor responsiveness to a number of anticancer agents currently used…”
Get full text

Biallelic somatic inactivation of the mismatch repair gene MLH1 in a primary skin melanoma by Castiglia, Daniele, Pagani, Elena, Alvino, Ester, Vernole, Patrizia, Marra, Giancarlo, Cannavò, Elda, Jiricny, Josef, Zambruno, Giovanna, D'Atri, Stefania

“…Inactivation of mismatch repair (MMR) genes has been linked to the hereditary nonpolyposis colon cancer syndrome and to a subset of sporadic cancers. A…”
Get full text

TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy by Vernole, Patrizia, Neale, Michael H, Barcaroli, Daniela, Munarriz, Eliana, Knight, Richard A, Tomasini, Richard, Mak, Tak W, Melino, Gerry, De Laurenzi, Vincenzo

“…Aneuploidy is a characteristic of most solid tumors, often associated with negative prognosis. It can arise from two principal mechanisms: from a tetraploid…”
Get full text

Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components by TENTORI, Lucio, PORTARENA, Ilaria, VERNOLE, Patrizia, DE FABRITIIS, Paolo, MADAIO, Raffaele, BALDUZZI, Alessandra, ROY, Rabindra, BONMASSAR, Enzo, GRAZIANI, Grazia

“…To evaluate the antitumor activity of single versus split exposure of neoplastic cells to temozolomide (TZM) and poly(ADP-ribose) polymerase (PARP) inhibitor…”
Get full text

An SRY-negative XX male with Huriez syndrome by Vernole, Patrizia, Terrinoni, Alessandro, Didona, Biagio, De Laurenzi, Vincenzo, Rossi, Pellegrino, Melino, Gerry, Grimaldi, Paola

“…This report studies a 42‐year‐old 46,XX patient affected by palmoplantar keratoderma, clinically classified as Huriez syndrome. The patient showed a male…”
Get full text

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents by Levati, Lauretta, Marra, Giancarlo, Lettieri, Teresa, D'Atri, Stefania, Vernole, Patrizia, Tentori, Lucio, Lacal, Pedro Miguel, Pagani, Elena, Bonmassar, Enzo, Jiricny, Josef, Graziani, Grazia

“…Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O6 position of guanine. These methyl adducts are removed…”
Get full text

Individual susceptibility to DNA telomerase inhibitors: a study on the chromosome instability induced by 3′‐azido‐3′‐deoxythymidine in lymphocytes of elderly twins by Caporossi, Daniela, Argentin, Gabriella, Pittaluga, Monica, Parisi, Paolo, Tedeschi, Bruna, Vernole, Patrizia, Cicchetti, Rosadele

“…The activation of telomerase in phytohemagglutinin‐stimulated peripheral lymphocytes is thought to play a role in telomere maintenance and DNA repair…”
Get full text

hMSH3 overexpression and cellular response to cytotoxic anticancer agents by Pepponi, Rita, Graziani, Grazia, Falcinelli, Sabrina, Vernole, Patrizia, Levati, Lauretta, Lacal, Pedro Miguel, Pagani, Elena, Bonmassar, Enzo, Jiricny, Josef, D'Atri, Stefania

“…Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O6-guanine methylating agents, 6-thioguanine,…”
Get full text

Sister chromatid exchanges and DNA topoisomerase II inhibitors: effect of low concentrations of etoposide (VP-16) in ataxia telangiectasia lymphoblastoid cell lines by Fantini, Cristina, Vernole, Patrizia, Tedeschi, Bruna, Caporossi, Daniela

“…The correlation between etoposide (VP-16) cytotoxicity and the induction of sister chromatid exchanges (SCEs) suggested that the promotion of DNA recombination…”
Get full text

Characteristic chromosomal fragility of human embryonic cells exposed in vitro to aphidicolin by CAPOROSSI, D, VERNOLE, P, NICOLETTI, B, TEDESCHI, B

“…The frequency and distribution of aphidicolin (APC)-induced common fragile sites (cfs) were analyzed in human embryonic cells of different origins. Embryonic…”
Get full text