Search Results - "VERMA, Udit"

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution by Hosein, Abdel Nasser, Huang, Huocong, Wang, Zhaoning, Parmar, Kamalpreet, Du, Wenting, Huang, Jonathan, Maitra, Anirban, Olson, Eric, Verma, Udit, Brekken, Rolf A

“…Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for…”
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Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression by Gaynor, Richard B, Yamamoto, Yumi, Verma, Udit N, Prajapati, Shashi, Kwak, Youn-Tae

“…Cytokine-induced activation of the IκB kinases (IKK) IKK-α and IKK-β is a key step involved in the activation of the NF-κB pathway. Gene-disruption studies of…”
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Revealing the Unanticipated: An Uncommon Case of Colorectal Adenocarcinoma Transitioning to Choriocarcinoma - A Case Report and Literature Review by Garcia Pleitez, Hector, Saowapa, Sakditad, Olavarria-Bernal, Diego, Juarez, Michel, Kanitthamniyom, Chanakarn, Verma, Udit

“…Choriocarcinomas are uncommon tumors, with non-gestational types occurring in both males and females. Primary choriocarcinoma of the colon is extremely rare…”
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Small Interfering RNAs Directed against β-Catenin Inhibit the in Vitro and in Vivo Growth of Colon Cancer Cells by VERMA, Udit N, SURABHI, Rama M, SCHMALTIEG, Aurelia, BECERRA, Carlos, GAYNOR, Richard B

“…The β-catenin and APC genes are key components of the Wnt signaling pathway. Mutation of these genes results in increased levels of the β-catenin protein,…”
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Randomized trial of irinotecan and cetuximab (IC) versus irinotecan, cetuximab and ramucirumab (ICR) as 2nd line therapy of advanced colorectal cancer (CRC) following oxaliplatin and bevacizumb based therapy: Result of E7208 by Hochster, H., Catalano, Paul J., O'Dwyer, Peter J., Mitchell, Edith P., Jill Cohen, Deirdre, Andrew Faller, Bryan, Kortmansky, Jeremy S., Mehta Kircher, Sheetal, Lacy, Jill, Lenz, Heinz-Josef, Verma, Udit N., Bowen Benson, Al

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Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference by WILLIAMS, Noelle Sevilir, GAYNOR, Richard B, SCOGGIN, Shane, VERMA, Udit, GOKASLAN, Tunc, SIMMANG, Clifford, FLEMING, Jason, TAVANA, Denise, FRENKEL, Eugene, BECERRA, Carlos

“…Purpose: The purpose of this study was to profile gene expression changes in colorectal tumors to identify new targets and strategies for the management of…”
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When Phenotype Does Not Match Genotype—The Importance of Returning to the Raw Data by Wachsmann, Megan B., Verma, Udit N., Arriaga, Yull E., Hammer, Suntrea T., Oliver, Dwight

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Enhanced Chemosensitivity to Irinotecan by RNA Interference-Mediated Down-Regulation of the Nuclear Factor-κB p65 Subunit by JUN GUO, VERMA, Udit N, GAYNOR, Richard B, FRENKEL, Eugene P, BECERRA, Carlos R

“…In preclinical tumor models, inhibition of nuclear factor-κB (NF-κB) has been associated with increased sensitivity to chemotherapeutic agents such as…”
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Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor by Kwak, Youn-Tae, Radaideh, Sofyan M, Ding, Lianghao, Li, Rui, Frenkel, Eugene, Story, Michael D, Girard, Luc, Minna, John, Verma, Udit N

“…The catalytic subunits of IκB kinase (IKK) complex, IKKα and IKKβ, are involved in activation of NF-κB and in mediating a variety of other biological…”
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Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression by Verma, Udit N, Yamamoto, Yumi, Prajapati, Shashi, Gaynor, Richard B

“…The I kappa B kinase (IKK) complex, which is composed of the two kinases IKK alpha and IKK beta and the regulatory subunit IKK gamma/nuclear factor-kappa B…”
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IκB Kinase α Regulates Subcellular Distribution and Turnover of Cyclin D1 by Phosphorylation by Kwak, Youn-Tae, Li, Rui, Becerra, Carlos R., Tripathy, Debu, Frenkel, Eugene P., Verma, Udit N.

“…IκB kinases (IKKs), IKKα and IKKβ, with a regulatory subunit IKKγ/NEMO constitute a high molecular weight IKK complex that regulates NF-κB activity. Although…”
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Sulindac Enhances Tumor Necrosis Factor-α-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-κB by BERMAN, Kevin S, VERMA, Udit N, HARBURG, Gwyndolen, MINNA, John D, COBB, Melanie H, GAYNOR, Richard B

“…Programmed cell death (apoptosis) is induced by certain anticancer therapies, and resistance to apoptosis is a major mechanism by which tumors evade these…”
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Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil by Guo, Jun, Zhou, An-wu, Fu, Yu-cai, Verma, Udit N, Tripathy, Debu, Frenkel, Eugene P, Becerra, Carlos R

“…Aim： Clinical treatment of solid tumors with docetaxel, flavopiridol, or 5-fluorouracil （5-FU） often encounters undesirable side effects and drug resistance…”
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Phase I dose escalation study with irinotecan, capecitabine, epirubicin, and granulocyte colony-stimulating factor support for patients with solid malignancies by Becerra, Carlos R, Verma, Udit N, Tran, Hia T, Tavana, Denise, Williams, Noelle S, Frenkel, Eugene P

“…Preclinical studies using sequences of topoisomerase I and II inhibitors suggested synergism; preliminary clinical studies, resulting in enhanced antitumor…”
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A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma by Hecht, J. Randolph, Benson, Al B., Vyushkov, Dmitry, Yang, Yingsi, Bendell, Johanna, Verma, Udit

“…Lessons Learned The safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group. The…”
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Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single‐Arm, Open‐Label Phase IIIb CONSIGN Study by Van Cutsem, Eric, Martinelli, Erika, Cascinu, Stefano, Sobrero, Alberto, Banzi, Maria, Seitz, Jean‐François, Barone, Carlo, Ychou, Marc, Peeters, Marc, Brenner, Baruch, Hofheinz, Ralf Dieter, Maiello, Evaristo, André, Thierry, Spallanzani, Andrea, Garcia‐Carbonero, Rocio, Arriaga, Yull E., Verma, Udit, Grothey, Axel, Kappeler, Christian, Miriyala, Ashok, Kalmus, Joachim, Falcone, Alfredo, Zaniboni, Alberto

“…Background In the phase III CORRECT trial, regorafenib significantly improved survival in treatment‐refractory metastatic colorectal cancer (mCRC). The CONSIGN…”
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Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the In Vitro Integrity of T Cells from Cancer Patients by Kobayashi, Masato, Chung, Jin-Sung, Beg, Muhammad, Arriaga, Yull, Verma, Udit, Courtney, Kevin, Mansour, John, Haley, Barbara, Khan, Saad, Horiuchi, Yutaka, Ramani, Vijay, Harker, David, Gopal, Purva, Araghizadeh, Farshid, Cruz, Jr, Ponciano D, Ariizumi, Kiyoshi

“…Blocking the function of myeloid-derived suppressor cells (MDSC) is an attractive approach for cancer immunotherapy. Having shown DC-HIL/GPNMB to be the…”
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Combining antivascular endothelial growth factor and anti-epidermal growth factor receptor antibodies: randomized phase II study of irinotecan and cetuximab with/without ramucirumab in second-line colorectal cancer (ECOG-ACRIN E7208) by Hochster, Howard S, Catalano, Paul, Weitz, Michelle, Mitchell, Edith P, Cohen, Deirdre, O’Dwyer, Peter J, Faller, Bryan A, Kortmansky, Jeremy S, O’Hara, Mark H, Kricher, Sheetal M, Lacy, Jill, Lenz, Heinz-Josef, Verma, Udit, Benson, Al B

“…Early studies showed promise of combined anti-epidermal growth factor receptor (EGFR) plus anti-vascular endothelial growth factor (VEGF) antibodies for…”
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Utilization of adjuvant chemotherapy in “ideal candidates” with stage III colon cancer by Soleja, Mohsin, Goksu, Suleyman Yasin, Sanford, Nina Niu, Beg, Muhammad Shaalan, Kainthla, Radhika, Sanjeevaiah, Aravind, Jones, Amy Little, Farkas, Linda, Verma, Udit, Hsieh, David, Kazmi, Syed Mohammad Ali

“…Abstract only 4103 Background: Prior studies have observed under-utilization of adjuvant chemotherapy (ACT) in stage III colon cancer. Our aims were to observe…”
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Clinicopathologic variables and outcomes in elderly colorectal cancer patients with microsatellite instability and multiple primary malignancies by Goksu, Suleyman Yasin, Zahid, Mohammad Faizan, Ozer, Muhammet, Sanford, Nina Niu, Sanjeevaiah, Aravind, Al Mutar, Salwan, Verma, Udit, Jones, Amy Little, Kainthla, Radhika, Hsieh, David, Beg, Muhammad Shaalan, Kazmi, Syed Mohammad Ali

“…Abstract only e15516 Background: The biology of microsatellite instability-high (MSI-H) in elderly colorectal cancer (CRC) patients is attributed to…”
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