Search Results - "VERLAAN, I"

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α by Gort, E H, van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, van Laar, T, van der Wall, E, Raman, V, van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
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711: Live imaging of cellular signaling in patient-derived tumor organoids by Verissimo, C, Ponsioen, B, Van de Wetering, M, Overmeer, R.M, Verlaan, I, Clevers, H, Bos, J.L, Snippert, H.J

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Hypoxia-inducible factor-1α expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas by GORT, E. H, GROOT, A. J, DERKS VAN DE VEN, T. L. P, VAN DER GROEP, P, VERLAAN, I, VAN LAAR, T, VAN DIEST, P. J, VAN DER WALL, E, SHVARTS, A

“…Hypoxia-inducible factor-1 alpha (HIF-1α) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to…”
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Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway by HORDIJK, P. L, VERLAAN, I, VAN CORVEN, E. J, MOOLENAAR, W. H

“…Lysophosphatidic acid (LPA) is a platelet-derived phospholipid that serves as a mitogen for fibroblasts. LPA activates its own G protein-coupled receptor(s)…”
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Growth factor-like action of phosphatidic acid by Moolenaar, W. H, Kruijer, W, Tilly, B. C, Verlaan, I, Bierman, A. J, de Laat, S. W

“…Phosphatidic acid (PA), an intriguing phospholipid that is rapidly produced during receptor-stimulated breakdown of phosphoinositides, has often been proposed…”
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A point mutation at the ATP‐binding site of the EGF‐receptor abolishes signal transduction by Moolenaar, W. H., Bierman, A. J., Tilly, B. C., Verlaan, I., Defize, L. H., Honegger, A. M., Ullrich, A., Schlessinger, J.

“…The EGF‐receptor (EGF‐R) is a transmembrane glycoprotein with intrinsic protein tyrosine kinase (TK) activity. To explore the importance of the receptor TK in…”
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High-Affinity Epidermal Growth Factor Binding Is Specifically Reduced by a Monoclonal Antibody, and Appears Necessary for Early Responses by Bellot, F., Moolenaar, W., Kris, R., Mirakhur, B., Verlaan, I., Ullrich, A., Schlessinger, J., Felder, S.

“…We have tested the effects of an mAb directed against the protein core of the extracellular domain of the human EGF receptor (mAb108), on the binding of EGF,…”
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Gap junction protein connexin-43 interacts directly with microtubules by Giepmans, Ben N.G., Verlaan, Ingrid, Hengeveld, Trudi, Janssen, Hans, Calafat, Jero, Falk, Matthias M., Moolenaar, Wouter H.

“…Gap junctions are specialized cell-cell junctions that mediate intercellular communication. They are composed of connexin proteins, which form transmembrane…”
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Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin by Tilly, B C, van Paridon, P A, Verlaan, I, de Laat, S W, Moolenaar, W H

“…In human A431 epidermoid carcinoma cells, epidermal growth factor (EGF) rapidly stimulates the breakdown of inositol phospholipids and raises cytoplasmic free…”
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cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts by HORDIJK, P. L, VERLAAN, I, JALINK, K, VAN CORVEN, E. J, MOOLENAAR, W. H

“…The mechanism by which cAMP inhibits growth factor-induced DNA synthesis in fibroblasts is not understood. Here we show that in Rat-1 fibroblasts, cAMP-raising…”
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Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase by Kranenburg, O, Verlaan, I, Moolenaar, W H

“…Internalization of activated receptors from the plasma membrane has been implicated in the activation of mitogen-activated protein (MAP) kinase. However, the…”
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Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1 by Zondag, G C, Postma, F R, Etten, I V, Verlaan, I, Moolenaar, W H

“…Sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are structurally related lipid mediators that act on distinct G-protein-coupled receptors to…”
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Second messenger modulation of epidermal growth factor receptor function does not occur at the level of receptor dimerization by Verheijden, G F, Verlaan, I, van Iersel, M J, Moolenaar, W H

“…Epidermal growth factor (EGF)-induced receptor dimerization may provide a mechanism for activation of the receptor protein tyrosine kinase and for initiation…”
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Expression of pp60v-src alters the ionic permeability of the plasma membrane in rat cells by van der Valk, J., Verlaan, I., de Laat, S.W., Moolenaar, W.H.

“…The transmembrane potential of Rous sarcoma virus (RSV)-infected Rat-1 cells, expressing the pp60v-src protein kinase, is markedly less negative (by…”
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Regulating c-Ras function. cholesterol depletion affects caveolin association, GTP loading, and signaling by Kranenburg, O, Verlaan, I, Moolenaar, W H

“…Cholesterol-rich and caveolin-containing microdomains of the plasma membrane, termed "caveolae," have been implicated in signal transduction. However, the role…”
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Connexin-43 interactions with ZO-1 and alpha- and beta-tubulin by Giepmans, B N, Verlaan, I, Moolenaar, W H

“…Gap junctions are composed of connexins that form transmembrane channels between adjacent cells. The C-terminal tail of connexin-43 (Cx43), the most widely…”
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The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2[alpha] by Gort, E H, Van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, Van Laar, T, Van Der Wall, E, Raman, V, Van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
Get full text

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2a by Gort, E H, van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, van Laar, T, van der Wall, E, Raman, V, van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
Get full text

Hypoxia-inducible factor-1a expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas by Gort, E H, Groot, A J, Derks van de Ven, T L P, van der Groep, P, Verlaan, I, van Laar, T, van Diest, P J, van der Wall, E, Shvarts, A

“…Hypoxia-inducible factor-1 alpha (HIF-1a) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response to…”
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Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas by Gort, E H, Groot, A J, Derks van de Ven, T L P, van der Groep, P, Verlaan, I, van Laar, T, van Diest, P J, van der Wall, E, Shvarts, A

“…Hypoxia-inducible factor-1 alpha (HIF-1alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1 and the key factor in cellular response…”
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