Relation of leukoaraiosis to lesion type in stroke patients

Nonspecific periventricular white matter lucencies on computed tomograms (leukoaraiosis) were found in 141 (38%) of 367 patients with ischemic or hemorrhagic strokes. Patients with leukoaraiosis were significantly older than those without it and were significantly more likely to have hypertension, d...

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Bibliographic Details
Published in:	Stroke (1970) Vol. 21; no. 6; pp. 890 - 894
Main Authors:	HIJDRA, A, VERBEETEN, B. JR, VERHULST, J. A. P. M
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 01-06-1990
Subjects:	Adult Age Factors Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Cerebral Cortex Cerebral Hemorrhage - diagnostic imaging Cerebral Infarction - diagnostic imaging Cross-Sectional Studies Humans Hypertension - complications Medical sciences Middle Aged Neurology Retrospective Studies Tomography, X-Ray Computed Vascular diseases and vascular malformations of the nervous system Human Brain Stroke Nervous system diseases Radiodiagnosis Exploration Computerized axial tomography Statistical study White matter Cerebrovascular disease
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Summary:	Nonspecific periventricular white matter lucencies on computed tomograms (leukoaraiosis) were found in 141 (38%) of 367 patients with ischemic or hemorrhagic strokes. Patients with leukoaraiosis were significantly older than those without it and were significantly more likely to have hypertension, diabetes mellitus, general vascular disease, and lacunar infarcts on computed tomograms but were less likely to have cortical infarcts. Because many of these variables may be mutually dependent, we performed a logistic regression analysis examining all clinical and computed tomographic variables. The analysis demonstrated that increasing age, lacunar infarcts, and hemorrhages were significant determinants of leukoaraiosis; cortical infarcts were also significantly, but negatively, correlated with leukoaraiosis. In patients with hemorrhages, leukoaraiosis occurred significantly more often when aneurysms or arteriovenous malformations were not demonstrated. These findings suggest that in patients with cerebrovascular disorders leukoaraiosis is associated with small-vessel disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.str.21.6.890