Search Results - "VERHEUL, H. A. M"

Selective Tissue Distribution of Tibolone Metabolites in Mature Ovariectomized Female Cynomolgus Monkeys after Multiple Doses of Tibolone by VERHEUL, H. A. M, VAN LERSEL, M. L. P. S, DELBRESSINE, L. P. C, KLOOSTERBOER, H. J

“…Tibolone is a selective tissue estrogenic activity regulator (STEAR). In postmenopausal women, it acts as an estrogen on brain, vagina, and bone, but not on…”
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Pharmacokinetic Parameters of Tibolone and Metabolites in Plasma, Urine, Feces, and Bile from Ovariectomized Cynomolgus Monkeys after a Single Dose or Multiple Doses of Tibolone by VERHEUL, H. A. M, TIMMER, C. J, VAN LERSEL, M. L. P. S, DELBRESSINE, L. P. C, KLOOSTERBOER, H. J

“…Levels of nonsulfated and sulfated tibolone metabolites were determined in plasma, urine, and feces from six ovariectomized, mature female cynomolgus monkeys…”
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Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone by Verheul, H.A.M., Kloosterboer, H.J.

“…Around the menopause, changes in ovarian secretion of steroids result in changes in brain function: hot flushes and sweating later followed by changes in mood,…”
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Molecular analysis of human endometrium : short-term tibolone signaling differs significantly from estrogen and estrogen + progestagen signaling by HANIFI-MOGHADDAM, P, BOERS-SIJMONS, B, BLOK, L. J, KLAASSENS, A. H. A, VAN WIJK, F. H, DEN BAKKER, M. A, OTT, M. C, SHIPLEY, G. L, VERHEUL, H. A. M, KLOOSTERBOER, H. J, BURGER, C. W

“…Tibolone, a tissue-selective compound with a combination of estrogenic, progestagenic, and androgenic properties, is used as an alternative for estrogen or…”
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Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone by Verheul, H A M, Timmer, C J, Kloosterboer, H J

“…The objective of this study was to determine pharmacokinetic parameters of sulfated tibolone metabolites after single dose and their accumulation after…”
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Pharmacokinetics of tibolone in early and late postmenopausal women by Timmer, C. J., Verheul, H. A. M., Doorstam, D. P.

“…Aims  Tibolone is a tissue‐specific compound with favourable effects on bone, vagina, climacteric symptoms, mood and sexual well being in postmenopausal women,…”
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Immunotherapy through the IL-2 receptor by VERHEUL, H. A. M, VERVELD, M, BOS, E. S

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Effects of gender and sex steroids on the immune response by Schuurs, A H, Verheul, H A

“…Elevated immune responses and the higher incidence of autoimmune diseases in female (compared to male) humans and animals have been known for a long time…”
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In situ Biorestoration of an Oil Contaminated Subsoil by van den Berg, R., Verheul, J H. A. M., Eikelboom, D. H.

“…The feasibility of in-situ biorestoration of contaminated subsoils is being investigated by RIVM in co-operation with TNO. This project is aimed at optimizing…”
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Tibolone and 5alpha-dihydrotestosterone alone or in combination with an antiandrogen in a rat breast tumour model by Deckers, G H, Verheul, H A M, van Aalst, G B T, Cremers, E A M, de Gooyer, M E, Kloosterboer, H J

“…Tibolone was combined with the antiandrogen flutamide to determine whether the inhibition of tumour growth in the prophylactic 7,12-dimethylbenz(a)anthracene…”
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Effects of estrogens and hormone replacement therapy on breast cancer risk and on efficacy of breast cancer therapies by Verheul, H.A.M., Coelingh-Bennink, H.J.T., Kenemans, P., Atsma, W.J., Burger, C.W., Eden, J.A., Hammar, M., Marsden, J., Purdie, D.W.

“…This review summarises preclinical and clinical data on effects of endogenous and exogenous estrogens on probability of breast cancer diagnosis, and on the…”
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Tibolone and 5α-dihydrotestosterone alone or in combination with an antiandrogen in a rat breast tumour model by Deckers, G.H, Verheul, H.A.M, van Aalst, G.B.T, Cremers, E.A.M, de Gooyer, M.E, Kloosterboer, H.J

“…Tibolone was combined with the antiandrogen flutamide to determine whether the inhibition of tumour growth in the prophylactic 7,12-dimethylbenz(a)anthracene…”
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Effects of ethinylestradiol on the course of spontaneous autoimmune disease in NZB/W and NOD mice by Verheul, H A, Verveld, M, Hoefakker, S, Schuurs, A H

“…Sex hormones affect (auto)immune responses in various ways. Investigations of the effects of estrogens have produced contradictory results. We studied the…”
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Therapeutic effects of nandrolone decanoate, tibolone, lynestrenol and ethylestrenol on Sjögren's syndrome-like disorder in NZB/W mice by VERHEUL, H. A. M, SCHOT, L. P. C, SCHUURS, A. H. W. M

“…Growth of mononuclear cell infiltration in submandibular glands is significantly inhibited by Org OD14 (tibolone), lynestrenol and ethylestrenol given orally…”
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Effects of steroids with different endocrine profiles on the development, morphology and function of the bursa of Fabricius in chickens by Verheul, H A, Tittes, E V, Kelder, J, Schuurs, A H

“…This paper describes the effect of various steroids on the anlage of the bursa of Fabricius in chickens. The steroids were administered by dipping embryonated…”
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Effect of nandrolone decanoate on Sjögren's syndrome like disorders in NZB/NZW mice by SCHOT, L. P. C, VERHEUL, H. A. M, SCHUURS, A. H. W. M

“…The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W…”
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Effects of sex, gonadectomy and several steroids on the development of insulin-dependent diabetes mellitus in the BB rat by VERHEUL, H. A. M, SCHOT, L. P. C, SCHUURS, A. H. W. M

“…The spontaneous development of the putative autoimmune insulin-dependent diabetes mellitus (IDDM) in BB rats was not affected by the following factors: (a)…”
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Effects of nandrolone decanoate in NZB/W mice treated concomitantly with maintenance doses of dexamethasone sodium phosphate by Verheul, H A, Deckers, G H, Schuurs, A H

“…Treatment of female or castrated male NZB/W mice with nandrolone decanoate (80 mg/kg s.c.), once every three weeks, delays the onset of murine lupus and…”
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Effects of tibolone, lynestrenol, ethylestrenol, and desogestrel on autoimmune disorders in NZB/W mice by Verheul, H A, Schot, L P, Deckers, G H, Schuurs, A H

“…The effects of two progestagens--lynestrenol, desogestrel--an anabolic steroid--ethylestrenol--and a compound with weak progestational, anabolic, androgenic,…”
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