Search Results - "VERHEIJEN, Jan"

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG by Iyer, Sangeetha, Sam, Feba S, DiPrimio, Nina, Preston, Graeme, Verheijen, Jan, Murthy, Kausalya, Parton, Zachary, Tsang, Hillary, Lao, Jessica, Morava, Eva, Perlstein, Ethan O

“…Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no…”
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Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content by Abdul-Hussien, Hazem, MD, Hanemaaijer, Roeland, PhD, Verheijen, Jan H., PhD, van Bockel, J. Hajo, MD, PhD, Geelkerken, Robert H., MD, PhD, Lindeman, Jan H.N., MD, PhD

“…Background Matrix metalloproteinase-9 (MMP-9) is thought to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline, a tetracycline…”
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MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression by Aschrafi, Armaz, PhD, Verheijen, Jan M., MSc, Gordebeke, Peter M., MSc, Menting, Kelly, MSc, Geenen, Bram, MSc, Kozicz, Tamas, MD, PhD, Olde Loohuis, Nikkie F., MSc, Jager, Amanda, MSc, Kos, Aron, MSc, Glennon, Jeffrey C., PhD, Palkovits, Miklos, MD, PhD, DSc, Martens, Gerard J.M., PhD, Kaplan, Barry B., PhD, Gaszner, Balázs, MD, PhD

“…Background Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger–Westphal nucleus (EWcp) of depressed suicide attempters or completers…”
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BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology by Mulder, Sandra D, van der Flier, Wiesje M, Verheijen, Jan H, Mulder, Cees, Scheltens, Philip, Blankenstein, Marinus A, Hack, C Erik, Veerhuis, Robert

“…Several studies have shown that reduced amyloid-beta 1-42 (Abeta(42)) and increased tau levels in cerebrospinal fluid (CSF) reflect increased Alzheimer's…”
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P348: Agnostic analysis of transcriptome sequencing of patients with suspected Mendelian diseases by Verheijen, Jan, William, Nancy, Figueiral, Marta, Olson, Rory, Panwar, Deepak, Osborne, Collin, Pinto e Vairo, Filippo, Klee, Eric

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P341: Identification of novel variants and phenotypic expansion in OGT-CDG by Verheijen, Jan, Vanhye, Lotte, Shaikh, Ayesha Niaz, Radenkovic, Silvia, Ranatunga, Wasantha, Pichurin, Pavel, Steyermark, Joan, Klee, Eric, Morava-Kozicz, Eva

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Collagenase matrix metalloproteinase-8 expressed in atherosclerotic carotid plaques is associated with systemic cardiovascular outcome by Peeters, Wouter, Moll, Frans L., Vink, Aryan, van der Spek, Peter J., de Kleijn, Dominique P.V., de Vries, Jean-Paul P.M., Verheijen, Jan H., Newby, Andrew C., Pasterkamp, Gerard

“…Aims Atherosclerotic plaque rupture and subsequent thrombus formation are the major cause of acute cardiovascular events. Local plaque markers may facilitate…”
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Active TGF‐β1 correlates with myofibroblasts and malignancy in the colorectal adenoma‐carcinoma sequence by Hawinkels, Lukas J. A. C., Verspaget, Hein W., Van Der Reijden, Johan J., Van Der Zon, Johanna M., Verheijen, Jan H., Hommes, Daniel W., Lamers, Cornelis B. H. W., Sier, Cornelis F. M.

“…Transforming growth factor‐β1 (TGF‐β1), a cytokine involved in various stages of cancer, is produced as a latent complex and requires processing to become…”
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Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger by Gierman, Lobke M, van El, Benno, van der Ham, Frits, Koudijs, Angela, Stoop, Reinout, Verheijen, Jan H, Kloppenburg, Margreet, van Osch, Gerjo J V M, Stojanovic-Susulic, Vedrana, Huizinga, Tom W J, Zuurmond, Anne-Marie

“…Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In…”
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Cathepsin K Is the Principal Protease in Giant Cell Tumor of Bone by Lindeman, Jan H.N., Hanemaaijer, Roeland, Mulder, Adri, Dijkstra, P.D. Sander, Szuhai, Károly, Bromme, Dieter, Verheijen, Jan H., Hogendoorn, Pancras C.W.

“…Giant cell tumor (GCT) of bone is a neoplasm of bone characterized by a localized osteolytic lesion. The nature of GCT is an enigma and the cell type(s) and…”
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Defining a new immune deficiency syndrome: MAN2B2-CDG by Verheijen, Jan, Wong, Sunnie Y., Rowe, Jared H., Raymond, Kimiyo, Stoddard, Jennifer, Delmonte, Ottavia M., Bosticardo, Marita, Dobbs, Kerry, Niemela, Julie, Calzoni, Enrica, Pai, Sung-Yun, Choi, Uimook, Yamazaki, Yasuhiro, Comeau, Anne Marie, Janssen, Erin, Henderson, Lauren, Hazen, Melissa, Berry, Gerard, Rosenzweig, Sergio D., Aldhekri, Hasan Hamdan, He, Miao, Notarangelo, Luigi D., Morava, Eva

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Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy? by van der Zijl, Nynke J., Hanemaaijer, Roeland, Tushuizen, Maarten E., Schindhelm, Roger K., Boerop, Jeannette, Rustemeijer, Cees, Bilo, Henk J., Verheijen, Jan H., Diamant, Michaela

“…Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity…”
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Detection of a Soluble Form of BACE-1 in Human Cerebrospinal Fluid by a Sensitive Activity Assay by Verheijen, Jan H, Huisman, Linda G.M, van Lent, Natascha, Neumann, Ulf, Paganetti, Paolo, Hack, C. Erik, Bouwman, Femke, Lindeman, Jan, Bollen, Edward L.E.M, Hanemaaijer, Roeland

“…Formation of deposits of the insoluble amyloid beta-peptide is believed to be causally related with neurodegeneration in Alzheimer disease (AD). The…”
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Effect of the anti‐tumor necrosis factor‐α antibody infliximab on the ex vivo mucosal matrix metalloproteinase–proteolytic phenotype in inflammatory bowel disease by Meijer, Martin J., Mieremet‐Ooms, Marij A.C., van Duijn, Wim, van der Zon, Annie M., Hanemaaijer, Roeland, Verheijen, Jan H., van Hogezand, Ruud A., Lamers, Cornelis B.H.W., Verspaget, Hein W.

“…Background: Previous studies have shown an upregulation of matrix metalloproteinases (MMPs) in intestinal tissue of patients with inflammatory bowel disease…”
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Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics by Verheijen, Jan, Sleegers, Kristel

“…Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most common neurodegenerative dementia. However, mechanistic insights and…”
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Statin treatment is not associated with consistent alterations in inflammatory status of carotid atherosclerotic plaques : A retrospective study in 378 patients undergoing carotid endarterectomy by VERHOEVEN, Bart A. N, MOLL, Frans L, VIRMANI, Renu, PASTERKAMP, Gerard, KOEKKOEK, Johan A. F, VAN DER WAL, Allard C, DE KLEIJN, Dominique P. V, DE VRIES, Jean Paul P. M, VERHEIJEN, Jan H, VELEMA, Evelyn, BUSSER, Els, SCHONEVELD, Arjan

“…Anti-inflammatory qualities are held partially responsible for the reduction of cardiovascular events after statin treatment. We examined the phenotype of…”
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Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma by Kuyvenhoven, Johan Ph, van Hoek, Bart, Blom, Eric, van Duijn, Wim, Hanemaaijer, Roeland, Verheijen, Jan H, Lamers, Cornelis B H W, Verspaget, Hein W

“…Matrix metalloproteinases (MMPs) have the ability to degrade basement membranes and may thus play an important role in extracellular matrix turnover in liver…”
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Age-related changes in plaque composition: a study in patients suffering from carotid artery stenosis by van Oostrom, Olivia, Velema, Evelyn, Schoneveld, Arjan H, de Vries, Jean Paul P M, de Bruin, Peter, Seldenrijk, Cees A, de Kleijn, Dominique P V, Busser, Els, Moll, Frans L, Verheijen, Jan H, Virmani, Renu, Pasterkamp, Gerard

“…The extent of atherosclerotic plaque burden and the incidence of atherosclerosis-related cardiovascular events accelerate with increasing age. The composition…”
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Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic Yucatan micropig by DE SMET, B. J. G. L, DE KLEIJN, D, HANEMAAIJER, R, VERHEIJEN, J. H, ROBERTUS, L, VAN DER HELM, Y. J. M, BORST, C, POST, M. J

“…Arterial remodeling after balloon angioplasty has been recognized as a major determinant of restenosis. Perturbation of collagen metabolism might be important…”
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Increased BACE1 activity in CSF of patients with an Alzheimer biomarker profile by Mulder, Sandra D, Mulder, Cees, Verheijen, Jan H, Scheltens, Philip, Hack, C. Erik, Blankenstein, Marinus A, Veerhuis, Robert

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