Search Results - "VERHAGE, Matthijs"

The Action Radius of Oxytocin Release in the Mammalian CNS: From Single Vesicles to Behavior by Chini, Bice, Verhage, Matthijs, Grinevich, Valery

“…The hypothalamic neuropeptide oxytocin (OT) has attracted the attention both of the scientific community and a general audience because of its prosocial…”
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Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes by Mohrmann, Ralf, de Wit, Heidi, Verhage, Matthijs, Neher, Erwin, Sørensen, Jakob B

“…Exocytosis requires formation of SNARE [soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor] complexes between vesicle and target…”
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Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling by Verweij, Frederik Johannes, Bebelman, Maarten P, Jimenez, Connie R, Garcia-Vallejo, Juan J, Janssen, Hans, Neefjes, Jacques, Knol, Jaco C, de Goeij-de Haas, Richard, Piersma, Sander R, Baglio, S Rubina, Verhage, Matthijs, Middeldorp, Jaap M, Zomer, Anoek, van Rheenen, Jacco, Coppolino, Marc G, Hurbain, Ilse, Raposo, Graça, Smit, Martine J, Toonen, Ruud F G, van Niel, Guillaume, Pegtel, D Michiel

“…Exosomes are small endosome-derived extracellular vesicles implicated in cell-cell communication and are secreted by living cells when multivesicular bodies…”
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Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo by Nassal, Joris P, Murphy, Fiona H, Toonen, Ruud F, Verhage, Matthijs

“…Different organelles traveling through neurons exhibit distinct properties in vitro, but this has not been investigated in the intact mammalian brain. We…”
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Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction by Abramian, Adlin, Hoogstraaten, Rein I, Murphy, Fiona H, McDaniel, Kathryn F, Toonen, Ruud F, Verhage, Matthijs

“…Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM…”
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Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons by Hoogstraaten, Rein I., van Keimpema, Linda, Toonen, Ruud F., Verhage, Matthijs

“…The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles (DCVs) in mammalian neurons are still poorly characterized. Here we…”
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Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles by He, Enqi, Wierda, Keimpe, van Westen, Rhode, Broeke, Jurjen H., Toonen, Ruud F., Cornelisse, L. Niels, Verhage, Matthijs

“…Synaptic transmission requires a stable pool of release-ready (primed) vesicles. Here we show that two molecules involved in SNARE-complex assembly, Munc13-1…”
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Mapping localization of 21 endogenous proteins in the Golgi apparatus of rodent neurons by van Bommel, Danique M., Toonen, Ruud F., Verhage, Matthijs

“…The Golgi apparatus is the major sorting hub in the secretory pathway and particularly important for protein sorting in neurons. Knowledge about protein…”
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Vti1a/b support distinct aspects of TGN and cis-/medial Golgi organization by van Bommel, Danique M., Toonen, Ruud F., Verhage, Matthijs

“…Retrograde trafficking towards the trans -Golgi network (TGN) is important for dense core vesicle (DCV) biogenesis. Here, we used Vti1a/b deficient neurons to…”
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The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators by Persoon, Claudia M., Hoogstraaten, Rein I., Nassal, Joris P., van Weering, Jan R.T., Kaeser, Pascal S., Toonen, Ruud F., Verhage, Matthijs

“…Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain…”
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CaMKII controls neuromodulation via neuropeptide gene expression and axonal targeting of neuropeptide vesicles by Moro, Alessandro, van Woerden, Geeske M, Toonen, Ruud F, Verhage, Matthijs

“…Ca2+/calmodulin-dependent kinase II (CaMKII) regulates synaptic plasticity in multiple ways, supposedly including the secretion of neuromodulators like…”
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Activity-dependent regulation of mitochondrial motility in developing cortical dendrites by Silva, Catia AP, Yalnizyan-Carson, Annik, Fernández Busch, M Victoria, van Zwieten, Mike, Verhage, Matthijs, Lohmann, Christian

“…Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby…”
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Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy by Kovačević, Jovana, Maroteaux, Gregoire, Schut, Desiree, Loos, Maarten, Dubey, Mohit, Pitsch, Julika, Remmelink, Esther, Koopmans, Bastijn, Crowley, James, Cornelisse, L Niels, Sullivan, Patrick F, Schoch, Susanne, Toonen, Ruud F, Stiedl, Oliver, Verhage, Matthijs

“…De novo heterozygous mutations in STXBP1 cause early infantile epileptic encephalopathy. Kovačević et al. analyse the underlying disease mechanisms in silico,…”
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Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission by Li, Hong, Fertuzinhos, Sofia, Mohns, Ethan, Hnasko, Thomas S., Verhage, Matthijs, Edwards, Robert, Sestan, Nenad, Crair, Michael C.

“…A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple features of early cortical development. It…”
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SNAP-25 gene family members differentially support secretory vesicle fusion by Arora, Swati, Saarloos, Ingrid, Kooistra, Robbelien, van de Bospoort, Rhea, Verhage, Matthijs, Toonen, Ruud F

“…Neuronal dense-core vesicles (DCVs) transport and secrete neuropeptides necessary for development, plasticity and survival, but little is known about their…”
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Vesicle Docking in Regulated Exocytosis by Verhage, Matthijs, Sørensen, Jakob B

“…In electron micrographs, many secretory and synaptic vesicles are found 'docked' at the target membrane, but it is unclear why and how. It is generally assumed…”
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Early Golgi Abnormalities and Neurodegeneration upon Loss of Presynaptic Proteins Munc18-1, Syntaxin-1, or SNAP-25 by Santos, Tatiana C, Wierda, Keimpe, Broeke, Jurjen H, Toonen, Ruud F, Verhage, Matthijs

“…The loss of presynaptic proteins Munc18-1, syntaxin-1, or SNAP-25 is known to produce cell death, but the underlying features have not been compared…”
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Organelle docking: R-SNAREs are late by Verhage, Matthijs

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Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi by Emperador-Melero, Javier, Huson, Vincent, van Weering, Jan, Bollmann, Christian, Fischer von Mollard, Gabriele, Toonen, Ruud F., Verhage, Matthijs

“…The SNAREs Vti1a/1b are implicated in regulated secretion, but their role relative to canonical exocytic SNAREs remains elusive. Here, we show that synaptic…”
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A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice by Remmelink, Esther, Chau, Uyen, Smit, August B., Verhage, Matthijs, Loos, Maarten

“…Many psychiatric disorders emerge during adolescence. The study of executive functions in animal models of these disorders critically requires short-duration…”
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