Search Results - "VEPSÄLÄINEN, Saila"

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease by Vepsäläinen, Saila, Koivisto, Henna, Pekkarinen, Elina, Mäkinen, Petra, Dobson, Gary, McDougall, Gordon J, Stewart, Derek, Haapasalo, Annakaisa, Karjalainen, Reijo O, Tanila, Heikki, Hiltunen, Mikko

“…A growing body of epidemiological evidence suggests that fruit and vegetable juices containing various phenolic compounds can reduce the risk of Alzheimer's…”
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Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice by Hiltunen, Mikko, Khandelwal, Vinoth K. M., Yaluri, Nagendra, Tiilikainen, Tea, Tusa, Maija, Koivisto, Henna, Krzisch, Marine, Vepsäläinen, Saila, Mäkinen, Petra, Kemppainen, Susanna, Miettinen, Pasi, Haapasalo, Annakaisa, Soininen, Hilkka, Laakso, Markku, Tanila, Heikki

“…According to epidemiological studies, type‐2 diabetes increases the risk of Alzheimer’s disease. Here, we induced hyperglycaemia in mice overexpressing mutant…”
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Increased expression of Aβ degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology by Vepsäläinen, Saila, Hiltunen, Mikko, Helisalmi, Seppo, Wang, Jun, van Groen, Thomas, Tanila, Heikki, Soininen, Hilkka

“…Expression levels of amyloid β (Aβ)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's…”
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No association between high temperature requirement 1 ( HTRA1 ) gene polymorphisms and Alzheimer's disease by Turunen, Mari, Vepsäläinen, Saila, Mäkinen, Petra, Helisalmi, Seppo, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko

“…Abstract High temperature requirement 1 ( HTRA1 ) gene is a plausible risk factor in Alzheimer's disease (AD) as it encodes a protease known to degrade…”
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Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish population by Vepsäläinen, Saila, Parkinson, Michele, Helisalmi, Seppo, Mannermaa, Arto, Soininen, Hilkka, Tanzi, Rudolph E, Bertram, Lars, Hiltunen, Mikko

“…The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer’s…”
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Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease by Natunen, Teemu, Helisalmi, Seppo, Vepsäläinen, Saila, Sarajärvi, Timo, Antikainen, Leila, Mäkinen, Petra, Herukka, Sanna-Kaisa, Koivisto, Anne Maria, Haapasalo, Annakaisa, Soininen, Hilkka, Hiltunen, Mikko

“…Accumulation of amyloid β-peptide (Aβ) in the brain of Alzheimer's disease (AD) patients has been postulated to reflect defects in Aβ degradation or clearance…”
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Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease by Helisalmi, Seppo, Tarvainen, Timo, Vepsäläinen, Saila, Koivisto, Anne Mari, Hiltunen, Mikko, Soininen, Hilkka

“…Single nucleotide polymorphisms (SNPs) in diabetes related peroxisome proliferator-activated receptor gamma ( PPARG) gene were investigated with a case–control…”
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Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients by VEPSALAINEN, Saila, HELISALMI, Seppo, KOIVISTO, Anne M, TAPANINEN, Toni, HILTUNEN, Mikko, SOININEN, Hilkka

“…The levels of somatostatin are consistently decreased in the brain and cerebrospinal fluid of Alzheimer's disease (AD) patients. The somatostatin gene is…”
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The expression and promoter specificity of the birch homologs for PISTILLATA/GLOBOSA and APETALA3/DEFICIENS by Lännenpää, Mika, Parkkinen, Sinikka, Järvinen, Pia, Lemmetyinen, Juha, Vepsäläinen, Saila, Savola, Tuuli, Keinonen, Kaija, Keinänen, Markku, Sopanen, Tuomas

“…B‐function genes determine the identity of petals and stamens in the flowers of model plants such as Arabidopsis and Antirrhinum. Here, we show that a putative…”
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APOE and Alzheimer disease: a major gene with semi-dominant inheritance by Genin, E, Hannequin, D, Wallon, D, Sleegers, K, Hiltunen, M, Combarros, O, Bullido, M J, Engelborghs, S, De Deyn, P, Berr, C, Pasquier, F, Dubois, B, Tognoni, G, Fiévet, N, Brouwers, N, Bettens, K, Arosio, B, Coto, E, Del Zompo, M, Mateo, I, Epelbaum, J, Frank-Garcia, A, Helisalmi, S, Porcellini, E, Pilotto, A, Forti, P, Ferri, R, Scarpini, E, Siciliano, G, Solfrizzi, V, Sorbi, S, Spalletta, G, Valdivieso, F, Vepsäläinen, S, Alvarez, V, Bosco, P, Mancuso, M, Panza, F, Nacmias, B, Bossù, P, Hanon, O, Piccardi, P, Annoni, G, Seripa, D, Galimberti, D, Licastro, F, Soininen, H, Dartigues, J-F, Kamboh, M I, Van Broeckhoven, C, Lambert, J C, Amouyel, P, Campion, D

“…Apolipoprotein E ( APOE ) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient…”
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Role of alpha-synuclein in presynaptic dopamine recruitment by Yavich, Leonid, Tanila, Heikki, Vepsäläinen, Saila, Jäkälä, Pekka

“…Real-time monitoring of stimulated dopamine release in mice with different alpha-synuclein expression was used to study the role of alpha-synuclein in…”
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The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study by Lambert, Jean-Charles, Sleegers, Kristel, González-Pérez, Antonio, Ingelsson, Martin, Beecham, Gary W, Hiltunen, Mikko, Combarros, Onofre, Bullido, Maria J, Brouwers, Nathalie, Bettens, Karolien, Berr, Claudine, Pasquier, Florence, Richard, Florence, Dekosky, Steven T, Hannequin, Didier, Haines, Jonathan L, Tognoni, Gloria, Fiévet, Nathalie, Dartigues, Jean-François, Tzourio, Christophe, Engelborghs, Sebastiaan, Arosio, Beatrice, Coto, Elicer, De Deyn, Peter, Del Zompo, Maria, Mateo, Ignacio, Boada, Merce, Antunez, Carmen, Lopez-Arrieta, Jesus, Epelbaum, Jacques, Schjeide, Brit-Maren Michaud, Frank-Garcia, Ana, Giedraitis, Vilmentas, Helisalmi, Seppo, Porcellini, Elisa, Pilotto, Alberto, Forti, Paola, Ferri, Raffaele, Delepine, Marc, Zelenika, Diana, Lathrop, Mark, Scarpini, Elio, Siciliano, Gabriele, Solfrizzi, Vincenzo, Sorbi, Sandro, Spalletta, Gianfranco, Ravaglia, Giovanni, Valdivieso, Fernando, Vepsäläinen, Saila, Alvarez, Victoria, Bosco, Paolo, Mancuso, Michelangelo, Panza, Francesco, Nacmias, Benedetta, Bossù, Paola, Hanon, Olivier, Piccardi, Paola, Annoni, Giorgio, Mann, David, Marambaud, Philippe, Seripa, Davide, Galimberti, Daniela, Tanzi, Rudolph E, Bertram, Lars, Lendon, Corinne, Lannfelt, Lars, Licastro, Federico, Campion, Dominique, Pericak-Vance, Margaret A, Soininen, Hilkka, Van Broeckhoven, Christine, Alpérovitch, Annick, Ruiz, Agustin, Kamboh, M Ilyas, Amouyel, Philippe

“…The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E gene (APOE). Recently, it…”
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Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease by VEPSÄLÄINEN, Saila, CASTREN, Eero, HELISALMI, Seppo, IIVONEN, Susan, MANNERMAA, Arto, LEHTOVIRTA, Maarit, HÄNNINEN, Tuomo, SOININEN, Hilkka, HILTUNEN, Mikko

“…According to previous biochemical and genetic findings, brain-derived neurotrophic factor (BDNF), via activation of its tyrosine kinase receptor B (TrkB), is…”
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Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology by Vepsäläinen, Saila, Hiltunen, Mikko, Helisalmi, Seppo, Wang, Jun, van Groen, Thomas, Tanila, Heikki, Soininen, Hilkka

“…Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with…”
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Contribution of genetic and dietary insulin resistance to Alzheimer’s phenotype in APP/PS1 transgenic mice by Hiltunen, Mikko, Soininen, Hilkka, Tanila, Heikki, Haapasalo, Annakaisa, Laakso, Markku, Tusa, Maija, Mäkinen, Petra, Krzisch, Marine, Koivisto, Hennariikka, Miettinen, Pasi, Tiilikainen, Tea, Vepsäläinen, Saila, Khandelwal, Vinoth, Kemppainen, Susanna

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O1‐03‐03: Contribution of genetic and dietary insulin resistance to Alzheimer's phenotype in APP/PS1 transgenic mice by Hiltunen, Mikko, Soininen, Hilkka, Tanila, Heikki, Haapasalo, Annakaisa, Laakso, Markku, Tusa, Maija, Mäkinen, Petra, Krzisch, Marine, Koivisto, Hennariikka, Miettinen, Pasi, Tiilikainen, Tea, Vepsäläinen, Saila, Khandelwal, Vinoth, Kemppainen, Susanna

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Genetic variation in apolipoprotein D and Alzheimer's disease by HELISALMI, Seppo, HILTUNEN, Mikko, VEPSÄLÄINEN, Saila, IIVONEN, Susan, CORDER, Elizabeth H, LEHTOVIRTA, Maarit, MANNERMAA, Arto, KOIVISTO, Anne Maria, SOININEN, Hilkka

“…Apolipoprotein D (apoD) is a lipoprotein-associated glycoprotein, structurally unrelated to apoE, that transports small hydrophobic ligands including…”
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P1-305: Genetic association of somatostatin in APOE4 positive carriers in finnish Alzheimer’s disease samples by Helisalmi, Seppo, Pylkkänen, Riikka, Vepsäläinen, Saila, Herukka, Sanna-Kaisa, Tapiola, Tero, Mannermaa, Arto, Hiltunen, Mikko, Pirttilä, Tuula, Soininen, Hilkka

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P4-082 Polymorphisms in the CYP19 gene confer increased risk for Alzheimer's disease by Iivonen, Susan, Corder, Elizabeth H., Lehtovirta, Maarit, Helisalmi, Seppo, Mannermaa, Arto, Vepsäläinen, Saila, Hänninen, Tuomo, Soininen, Hilkka, Hiltunen, Mikko

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P4-123 Genetic analysis of BDNF and TRKB gene polymorphisms in Alzheimer's disease by Vepsäläinen, Saila H., Castren, Eero, Lehtovirta, Maarit, Iivonen, Susan, Helisalmi, Seppo, Mannermaa, Arto, Hänninen, Tuomo, Soininen, Hilkka, Hiltunen, Mikko

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