Search Results - "VENHORST, Jennifer"

Battling Enteropathogenic Clostridia: Phage Therapy for Clostridioides difficile and Clostridium perfringens by Venhorst, Jennifer, van der Vossen, Jos M. B. M., Agamennone, Valeria

“…The pathogenic Clostridioides difficile and Clostridium perfringens are responsible for many health care-associated infections as well as systemic and enteric…”
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Oncostatin M: Risks and Benefits of a Novel Therapeutic Target for Atherosclerosis by Rankouhi, Tanja Rouhani, Keulen, Daniëlle van, Tempel, Dennie, Venhorst, Jennifer

“…Cardiovascular disease (CVD) is a leading cause of death worldwide. It is predicted that approximately 23.6 million people will die from CVDs annually by 2030…”
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Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development by González Hernández, Manuel A., Verschuren, Lars, Caspers, Martien P.M., Morrison, Martine C., Venhorst, Jennifer, van den Berg, Jelle T., Coornaert, Beatrice, Hanemaaijer, Roeland, van Westen, Gerard J. P.

“…The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial…”
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Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis by Venhorst, Jennifer, Hanemaaijer, Roeland, Dulos, Remon, Caspers, Martien P M, Toet, Karin, Attema, Joline, de Ruiter, Christa, Kalkman, Gino, Rouhani Rankouhi, Tanja, de Jong, Jelle C B C, Verschuren, Lars

“…An target discovery pipeline was developed by including a directional and weighted molecular disease network for metabolic dysfunction-associated…”
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Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities by Venhorst, Jennifer, ter Laak, Antonius M, Commandeur, Jan N. M, Funae, Yoshihiko, Hiroi, Toyoko, Vermeulen, Nico P. E

“…The ligand-binding characteristics of rat and human CYP2D isoforms, i.e., rat CYP2D1−4 and human CYP2D6, were investigated by measuring IC50 values of 11 known…”
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Identification of Ligand-binding Site III on the Immunoglobulin-like Domain of the Granulocyte Colony-stimulating Factor Receptor by Layton, Judith E., Hall, Nathan E., Connell, Fiona, Venhorst, Jennifer, Treutlein, Herbert R.

“…The granulocyte colony-stimulating factor receptor (G-CSF-R) forms a tetrameric complex with G-CSF containing two ligand and two receptor molecules. The…”
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Target–drug interactions: first principles and their application to drug discovery by Núñez, Sara, Venhorst, Jennifer, Kruse, Chris G.

“…In this review, we begin by introducing the basic principles of kinetics and thermodynamics of target–drug binding within the context of drug discovery. In…”
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Design, Synthesis, and Characterization of 7-Methoxy-4-(aminomethyl)coumarin as a Novel and Selective Cytochrome P450 2D6 Substrate Suitable for High-Throughput Screening by Onderwater, Rob C. A, Venhorst, Jennifer, Commandeur, Jan N. M, Vermeulen, Nico P. E

“…In this study, a selective substrate for cytochrome P450 2D6 was designed using a small molecule model developed by M. J. De Groot et al. [(1997) Chem. Res…”
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Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity by VENHORST, Jennifer, ONDERWATER, Rob C. A, MEERMAN, John H. N, COMMANDEUR, Jan N. M, VERMEULEN, Nico P. E

“…A series of six structural analogs of 7-methoxy-4-(aminomethyl)-coumarin (MAMC), a recently developed high-throughput substrate of P450 2D6 (CYP2D6), was…”
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Targettri: A toxicity-based triaging system for novel drug targets by Venhorst, Jennifer, van Someren, Eugene P., van de Brug, Fred J., Kalkman, Gino J., Folkertsma, Simon

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Analysis of HSP90 using a toxicity-based triaging approach for drug targets by Venhorst, Jennifer, van Someren, Eugene P., van de Brug, Fred J., Kalkman, Gino J., Folkertsma, Simon, Krul, Cyrille A.M.

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Assessment of Scaffold Hopping Efficiency by Use of Molecular Interaction Fingerprints by Venhorst, Jennifer, Núñez, Sara, Terpstra, Jan Willem, Kruse, Chris G

“…A novel scoring algorithm based on molecular interaction fingerprints (IFPs) was comparatively evaluated in its scaffold hopping efficiency against four…”
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Assessment of a Novel Scoring Method Based on Solvent Accessible Surface Area Descriptors by Núñez, Sara, Venhorst, Jennifer, Kruse, Chris G

“…A novel scoring algorithm based on unique solvent accessible surface area (SASA) descriptors was comparatively evaluated for its database enrichment potential…”
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N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features by van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I, de Korte, Cor G, de Looff, Wouter, Verhoog, Stefan, van Wees, Jan-Willem, van Hoeve, Martijn, van de Woestijne, Rob P, van der Neut, Martina A. W, Borst, Alice J. M, van Dongen, Maria J. P, de Bruin, Natasja M. W. J, Keizer, Hiskias G, Kruse, Chris G

“…The 5-HT6 receptor (5-HT6R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT6R…”
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A holistic approach to the safety assessment of exploratory drug targets by Venhorst, Jennifer, Rankouhi, Tanja Rouhani, Verschuren, Lars, van Someren, Eugene P., Kuper, Frieke C., Wolterbeek, Andre P.M., van de Brug, Fred J., Folkertsma, Simon, Krul, Cyrille A.M.

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Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT sub(6) antagonistic binding pocket by Loevezijn, Arnold van, Venhorst, Jennifer, Bakker, Wouter IIwema, Lange, Jos HM, Looff, Wouter de, Henzen, Remco, Vries, Jelle de, Woestijne, Rob Pvan de, Hartog, Arnold Pden, Verhoog, Stefan, van der Neut, Martina AW, Bruin, Natasja MWJde, Kruse, Chris G

“…The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT sub(6) antagonists with unique structural features was recently disclosed. Here…”
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Optimization of N ′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT 6 antagonistic binding pocket by van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.

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Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket by van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.

“…[Display omitted] The discovery of non-basic N′-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently…”
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Design of a High Fragment Efficiency Library by Molecular Graph Theory by Venhorst, Jennifer, Núñez, Sara, Kruse, Chris G

“…Molecular graph theory was used to design a unique and diverse, high-efficiency fragment screening collection. A data set retrieved from the annotated database…”
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Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors by Lange, Jos H.M., Venhorst, Jennifer, van Dongen, Maria J.P., Frankena, Jurjen, Bassissi, Firas, de Bruin, Natasja M.W.J., Besten, Cathaline den, de Beer, Stephanie B.A., Oostenbrink, Chris, Markova, Natalia, Kruse, Chris G.

“…Many early drug research efforts are too reductionist thereby not delivering key parameters such as kinetics and thermodynamics of target–ligand binding. A set…”
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