Search Results - "VEIGL, M. L"

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53 by ESHLEMAN, J. R, CASEY, G, KOCHERA, M. E, SEDWICK, W. D, SWINLER, S. E, VEIGL, M. L, WILLSON, J. K. V, SCHWARTZ, S, MARKOWITZ, S. D

“…Fourteen colorectal cancer cell lines, categorized according to the presence or absence of microsatellite instability, were further analysed for chromosomal…”
Get full text

Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability by MA, A.-H, LIANG XIA, VEIGL, M. L, MARKOWITZ, S. D, SEDWICK, W. D, LITTMAN, S. J, SWINLER, S, LADER, G, POLINKOVSKY, A, OLECHNOWICZ, J, KASTURI, L, LUTTERBAUGH, J, MODRICH, P

“…Inactivation of DNA-mismatch repair underlies the genesis of microsatellite unstable (MSI) colon cancers. hPMS2 is one of several genes encoding components of…”
Get full text

Biallelic Inactivation of hMLH1 by Epigenetic Gene Silencing, a Novel Mechanism Causing Human MSI Cancers by Veigl, Martina L., Kasturi, Lakshmi, Olechnowicz, Joseph, Ma, AiHong, Lutterbaugh, James D., Periyasamy, Sumudra, Li, Guo-Min, Drummond, James, Modrich, Paul L., Sedwick, W. David, Markowitz, Sanford D.

“…Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced…”
Get full text

Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells by CHEN, W.-D, ESHLEMAN, J. R, AMINOSHARIAE, M. R, MA, A.-H, VELOSO, N, MARKOWITZ, S. D, SEDWICK, W. D, VEIGL, M. L

“…Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite…”
Get full text

Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation by Yan, T, Schupp, J E, Hwang, H S, Wagner, M W, Berry, S E, Strickfaden, S, Veigl, M L, Sedwick, W D, Boothman, D A, Kinsella, T J

“…Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest after high-dose-rate ionizing…”
Get full text

Specificity of bischloroethylnitrosourea-induced mutation in a Chinese hamster ovary cell line transformed to express human O6-alkylguanine-DNA alkyltransferase by MINNICK, D. T, GERSON, S. L, DUMENCO, L. L, VEIGL, M. L, SEDWICK, W. D

“…The human O6-alkylguanine-DNA alkyltransferase complementary DNA was transfected into the alkyltransferase-deficient Chinese hamster ovary cell line, D422, in…”
Get full text

Increased transversions in a novel mutator colon cancer cell line by ESHLEMAN, J. R, DONOVER, P. S, VEIGL, M. L, LITTMAN, S. J, SWINLER, S. E, LI, G.-M, LUTTERBAUGH, J. D, WILLSON, J. K. V, MODRICH, P, SEDWICK, W. D, MARKOWITZ, S. D

“…We describe a novel mutator phenotype in the Vaco411 colon cancer cell line which increases the spontaneous mutation rate 10-100-fold over background. This…”
Get full text

Calcium and calmodulin in cell growth and transformation by Veigl, M L, Vanaman, T C, Sedwick, W D

Get more information

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer by Eshleman, J R, Lang, E Z, Bowerfind, G K, Parsons, R, Vogelstein, B, Willson, J K, Veigl, M L, Sedwick, W D, Markowitz, S D

“…Hereditary Non-Polyposis Colon Cancer (HNPCC) tumors and some sporadic colon cancers acquire somatic changes in the length of microsatellite sequences. We…”
Get more information

The uses and limitations of calmodulin antagonists by Veigl, M L, Klevit, R E, Sedwick, W D

Get more information

DNA sequence specificity of doxorubicin-induced mutational damage in uvrB- escherichia coli by ANDERSON, R. D, VEIGL, M. L, BAXTER, J, SEDWICK, W. D

“…In the absence of excision repair, doxorubicin caused a striking (41-fold) increase in the frequency of large deletion mutations extending from the lac…”
Get full text

Rapid mapping of deletion and duplication mutations by the polymerase chain reaction by Anderson, R D, Veigl, M L, Sedwick, W D

Get more information

Induction of myeloid differentiation of HL-60 cells with naphthalene sulfonamide calmodulin antagonists by VEIGL, M. L, SEDWICK, W. D, NIEDEL, J, BRANCH, M. E

“…The naphthalene sulfonamide calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide,…”
Get full text

Differences in calmodulin levels of normal and transformed cells as determined by culture conditions by VEIGL, M. L, VANAMAN, T. C, BRANCH, M. E, SEDWICK, W. D

“…Several studies have suggested that calmodulin (CAM) levels increase in cells as a consequence of transformation by RNA tumor viruses. This study examines…”
Get full text

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability by Eshleman, J R, Markowitz, S D, Donover, P S, Lang, E Z, Lutterbaugh, J D, Li, G M, Longley, M, Modrich, P, Veigl, M L, Sedwick, W D

“…Colon cancer and an increasing number of other cancers have been found to exhibit instability of DNA microsatellite sequences. Such tumors have been designated…”
Get more information

DNA base modification: ionized base pairs and mutagenesis by Sowers, L C, Shaw, B R, Veigl, M L, Sedwick, W D

“…The nature of hydrogen bonding between normal and modified bases has been re-examined. It is proposed that hydrogen-bonding schemes may involve tautomeric,…”
Get more information

Excision repair reduces doxorubicin-induced genotoxicity by Anderson, R D, Veigl, M L, Baxter, J, Sedwick, W D

“…LacI mutations induced by doxorubicin in a wild-type, uvr(A)BC repair-proficient E. coli strain were analyzed by DNA sequencing. These mutations were…”
Get more information

Sequencing of double-stranded polymerase chain reaction products for mutation analysis by Anderson, R D, Bao, C Y, Minnick, D T, Baxter, J, Veigl, M L, Sedwick, W D

“…This report describes a reproducible, straightforward approach to sequencing double-stranded DNA products from the polymerase chain reaction (PCR) for analysis…”
Get more information

Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese hamster ovary cell line by Minnick, D T, Veigl, M L, Sedwick, W D

“…The mutational specificity of the alkylating agent 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) was analyzed at the endogenous hemizygous adenine…”
Get full text

Effect of isopropyl-beta-D-thiogalactopyranosid induction of the lac operon on the specificity of spontaneous and doxorubicin-induced mutations in Escherichia coli by Veigl, M L, Donover, S P, Anderson, R D, Akst, L, Sedwick, C E, Sedwick, W D

“…Previous studies of doxorubicin-induced mutations employing F' lacl/lacO as an endogenous gene target have focused on properties of large deletions with 3'…”
Get more information