Pubertal Development is Normal in Adolescents After Renal Transplantation in Childhood

This study was conducted to evaluate the pubertal development in adolescents after renal transplantation (RTx) in childhood. We performed a retrospective review of medical records of 109 RTx recipients (72 males) transplanted at the median age of 4.5 years (range: 0.9-15.8 years). Data on the clinic...

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Bibliographic Details
Published in:	Transplantation Vol. 92; no. 4; pp. 404 - 409
Main Authors:	TAINIO, Juuso, QVIST, Erik, VEHMAS, Reeta, JAHNUKAINEN, Kirsi, HÖLTTÄ, Tuula, VALTA, Helena, JAHNUKAINEN, Timo, JALANKO, Hannu
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 27-08-2011
Subjects:	Adolescence Adolescent Age Age Factors Biological and medical sciences Body Height Bone Bone grafts Bone growth Child Child, Preschool Children Cohort Studies Data processing Development Female Finland Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Gonadal Steroid Hormones - blood Hormones Human Growth Hormone - therapeutic use Humans Immunosuppressive Agents - therapeutic use Infant Kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - pathology Kidney Transplantation - physiology Male medical records Medical sciences Medicin och hälsovetenskap Menarche Menarche - physiology Puberty Puberty - physiology Puberty, Delayed - etiology Puberty, Delayed - pathology Puberty, Delayed - physiopathology Retrospective Studies Serum levels Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Tissue, organ and graft immunology Finland Human Puberty Homotransplantation Normal Kidney Treatment Urinary system Surgery Adolescent Development Graft Child Kidney transplantation
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Summary:	This study was conducted to evaluate the pubertal development in adolescents after renal transplantation (RTx) in childhood. We performed a retrospective review of medical records of 109 RTx recipients (72 males) transplanted at the median age of 4.5 years (range: 0.9-15.8 years). Data on the clinical signs of puberty, growth, bone age, medication, and graft function of 98 patients were analyzed. Furthermore, serum levels of reproductive hormones in 87 patients were assessed to evaluate the progression and outcome of pubertal development. The age at the onset of puberty averaged 12.7 years (range: 9.4-16.2 years) in 55 males and 10.7 years (range: 8.9-12.7 years) in 29 females. The mean age at menarche was 12.5 years (range: 10.5-14.5 years). Twenty-two percent of the boys and none of the girls had a moderately delayed onset of puberty. Children who underwent RTx before the age of 5 years reached puberty earlier than those transplanted at later age (boys 12.3±1.2 vs. 13.4±1.5 years, P<0.01; girls 10.3±0.9 vs. 11.0±1.0 years, P>0.05). The mean length of puberty was 3.9 and 4.7 years for boys and girls, respectively. The bone age was delayed in practically all, and final height was reached at the mean age of 18.1 and 16.0 years in boys and girls, respectively. Pubertal maturation resulted in acceptable final height and reproductive hormone status in great majority of the patients. Pubertal development was normal in all female and most male adolescents after RTx in childhood.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0041-1337 1534-6080 1534-6080
DOI:	10.1097/TP.0b013e3182247bd5