Search Results - "VEGRAN, Frédérique"

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors by BOIDOT, Romain, VEGRAN, Frédérique, MEULLE, Aline, LE BRETON, Aude, DESSY, Chantal, SONVEAUX, Pierre, LIZARD-NACOL, Sarab, FERON, Olivier

“…The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and out of tumor cells. Whereas most oxidative cancer cells import lactate…”
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Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen by Limagne, Emeric, Euvrard, Romain, Thibaudin, Marion, Rébé, Cédric, Derangère, Valentin, Chevriaux, Angélique, Boidot, Romain, Végran, Frédérique, Bonnefoy, Nathalie, Vincent, Julie, Bengrine-Lefevre, Leila, Ladoire, Sylvain, Delmas, Dominique, Apetoh, Lionel, Ghiringhelli, François

“…Host immunity controls the development of colorectal cancer, and chemotherapy used to treat colorectal cancer is likely to recruit the host immune system at…”
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Role of Cytokines and Chemokines in Angiogenesis in a Tumor Context by Geindreau, Mannon, Bruchard, Mélanie, Vegran, Frédérique

“…During carcinogenesis, tumors set various mechanisms to help support their development. Angiogenesis is a crucial process for cancer development as it drives…”
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Canonical and non-canonical functions of NLRP3 by Accogli, Théo, Hibos, Christophe, Vegran, Frédérique

“…[Display omitted] •Presents an overview on the knowledge acquired on the role NLRP3 in its canonical function.•Gives an insight on NLRP3 newly discovered…”
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SOCS3 Transactivation by PPARγ Prevents IL-17-Driven Cancer Growth by BERGER, Hélène, VEGRAN, Frédérique, CHEVRIAUX, Angélique, REBE, Cédric, RYFFEL, Bernhard, POT, Caroline, HICHAMI, Aziz, DESVERGNE, Béatrice, GHIRINGHELLI, François, APETOH, Lionel, CHIKH, Madijd, GILARDI, Federica, LADOIRE, Sylvain, BUGAUT, Hélène, MIGNOT, Grégoire, CHALMIN, Fanny, BRUCHARD, Mélanie, DERANGERE, Valentin

“…Activation of the transcription factor PPARγ by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion,…”
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Survivin-3B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy by VEGRAN, Frédérique, MARY, Romain, GIBEAUD, Anne, MIRJOLET, Céline, COLLIN, Bertrand, OUDOT, Alexandra, CHARON-BARRA, Céline, ARNOULD, Laurent, LIZARD-NACOL, Sarab, BOIDOT, Romain

“…Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we…”
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The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management of patients and families? by Eliade, Marie, Skrzypski, Jeremy, Baurand, Amandine, Jacquot, Caroline, Bertolone, Geoffrey, Loustalot, Catherine, Coutant, Charles, Guy, France, Fumoleau, Pierre, Duffourd, Yannis, Arnould, Laurent, Delignette, Alexandra, Padéano, Marie-Martine, Lepage, Côme, Raichon-Patru, Géraldine, Boudrant, Axelle, Bône-Lépinoy, Marie-Christine, Villing, Anne-Laure, Charpin, Aurélie, Peignaux, Karine, Chevrier, Sandy, Vegran, Frédérique, Ghiringhelli, François, Boidot, Romain, Sevenet, Nicolas, Lizard, Sarab, Faivre, Laurence

“…Until recently, the molecular diagnosis of hereditary breast and ovarian cancer (HBOC) was mostly based on BRCA1/2 testing. Next generation sequencing and the…”
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Overexpression of Caspase-3s Splice Variant in Locally Advanced Breast Carcinoma Is Associated with Poor Response to Neoadjuvant Chemotherapy by VEGRAN, Frédérique, BOIDOT, Romain, OUDIN, Claire, RIEDINGER, Jean-Marc, BONNETAIN, Franck, LIZARD-NACOL, Sarab

“…Purpose: CASP-3 gene gives rise, by alternative splicing to a caspase-3s variant, to the antagonist apoptotic property of caspase-3. Deregulation of splicing…”
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Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis by VEGRAN, Frédérique, BOIDOT, Romain, MICHIELS, Carine, SONVEAUX, Pierre, FERON, Olivier

“…Lactate generated from pyruvate fuels production of intracellular NAD(+) as an end result of the glycolytic process in tumors. Elevated lactate concentration…”
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Predictive value of survivin alternative transcript expression in locally advanced breast cancer patients treated with neoadjuvant chemotherapy by Boidot, Romain, Vegran, Frédérique, Lizard-Nacol, Sarab

“…Survivin, a member of the apoptosis inhibitor protein family, is expressed in numerous human tumours, and its expression is described as a negative prognostic…”
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The expression of BIRC5 is correlated with loss of specific chromosomal regions in breast carcinomas by Boidot, Romain, Vegran, Frédérique, Jacob, Delphine, Chevrier, Sandy, Gangneux, Nicolas, Taboureau, Johann, Oudin, Claire, Rainville, Vinciane, Mercier, Liliane, Lizard-Nacol, Sarab

“…Expression of BIRC5 (survivin), a member of the inhibitor of apoptosis protein (IAP) family, is elevated in fetal tissues and in various human cancers…”
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PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer by Dosset, Magalie, Vargas, Thaiz Rivera, Lagrange, Anaïs, Boidot, Romain, Végran, Frédérique, Roussey, Aurélie, Chalmin, Fanny, Dondaine, Lucile, Paul, Catherine, Marie-Joseph, Elodie Lauret, Martin, François, Ryffel, Bernhard, Borg, Christophe, Adotévi, Olivier, Ghiringhelli, François, Apetoh, Lionel

“…Background: Chemotherapy is currently evaluated in order to enhance the efficacy of immune checkpoint blockade (ICB) therapy in colorectal cancer. However, the…”
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Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses by Bruchard, Mélanie, Geindreau, Mannon, Perrichet, Anaïs, Truntzer, Caroline, Ballot, Elise, Boidot, Romain, Racoeur, Cindy, Barsac, Emilie, Chalmin, Fanny, Hibos, Christophe, Baranek, Thomas, Paget, Christophe, Ryffel, Bernhard, Rébé, Cédric, Paul, Catherine, Végran, Frédérique, Ghiringhelli, François

“…Tumors poorly infiltrated by T cells are more resistant to immunogenic chemotherapies and checkpoint inhibition than highly infiltrated tumors. Using murine…”
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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth by Bruchard, Mélanie, Mignot, Grégoire, Derangère, Valentin, Chalmin, Fanny, Chevriaux, Angélique, Végran, Frédérique, Boireau, Wilfrid, Simon, Benoit, Ryffel, Bernhard, Connat, Jean Louis, Kanellopoulos, Jean, Martin, François, Rébé, Cédric, Apetoh, Lionel, Ghiringhelli, François

“…Gemcitabine and 5-fluorouracil are two commonly used chemotherapeutic agents for the treatment of cancer. François Ghiringhelli and colleagues now report that…”
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Alternative Splicing in Cancer and Immune Cells by Bernard, Antoine, Boidot, Romain, Végran, Frédérique

“…Splicing is a phenomenon enabling the excision of introns from pre-mRNA to give rise to mature mRNA. All the 20,000 genes of the human genome are concerned by…”
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis by Sonveaux, Pierre, Copetti, Tamara, De Saedeleer, Christophe J, Végran, Frédérique, Verrax, Julien, Kennedy, Kelly M, Moon, Eui Jung, Dhup, Suveera, Danhier, Pierre, Frérart, Françoise, Gallez, Bernard, Ribeiro, Anthony, Michiels, Carine, Dewhirst, Mark W, Feron, Olivier

“…Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue…”
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Editorial: Targeting glucose metabolism in cancer immunity and immunotherapy by Feron, Olivier, Chang, Chih-Hao, Végran, Frédérique

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Impact of Lipid Metabolism on Antitumor Immune Response by Mabrouk, Nesrine, Lecoeur, Baptiste, Bettaieb, Ali, Paul, Catherine, Végran, Frédérique

“…Over the past decade, metabolic reprogramming has been defined as a hallmark of cancer. More recently, a large number of studies have demonstrated that…”
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Th9 cells: a novel CD4 T-cell subset in the immune war against cancer by Végran, Frédérique, Apetoh, Lionel, Ghiringhelli, François

“…CD4 T cells are key components of the immune system that shape the anticancer immune response in animal models and in humans. The biology of CD4 T cells is…”
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Transcriptional regulation of the survivin gene by Boidot, Romain, Végran, Frédérique, Lizard-Nacol, Sarab

“…Survivin, a small member of the inhibitors of the apoptosis protein family, is highly deregulated in cancer. It is weakly expressed in normal tissues but very…”
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