Search Results - "VAZQUEZ, Edwin J"

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes by ROSCA, Mariana G, VAZQUEZ, Edwin J, QUN CHEN, KERNER, Janos, KERN, Timothy S, HOPPEL, Charles L

“…Mitochondrial reactive oxygen species (ROS) cause kidney damage in diabetes. We investigated the source and site of ROS production by kidney cortical tubule…”
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Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart by Vazquez, Edwin J, Berthiaume, Jessica M, Kamath, Vasudeva, Achike, Olisaemeka, Buchanan, Elizabeth, Montano, Monica M, Chandler, Margaret P, Miyagi, Masaru, Rosca, Mariana G

“…Cardiomyopathy is a major complication of diabetes. Our study was aimed to identify the sites of mitochondrial dysfunction and delineate its consequences on…”
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Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation by Rosca, Mariana G., Vazquez, Edwin J., Kerner, Janos, Parland, William, Chandler, Margaret P., Stanley, William, Sabbah, Hani N., Hoppel, Charles L.

“…Aims Mitochondrial dysfunction is a major factor in heart failure (HF). A pronounced variability of mitochondrial electron transport chain (ETC) defects is…”
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Apoptosis inducing factor deficiency causes retinal photoreceptor degeneration. The protective role of the redox compound methylene blue by Mekala, Naveen K, Kurdys, Jacob, Depuydt, Mikayla M, Vazquez, Edwin J, Rosca, Mariana G

“…Dysfunction in mitochondrial oxidative phosphorylation (OXPHOS) underlies a wide spectrum of human ailments known as mitochondrial diseases. Deficiencies in…”
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Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer by Babcook, Melissa A, Shukla, Sanjeev, Fu, Pingfu, Vazquez, Edwin J, Puchowicz, Michelle A, Molter, Joseph P, Oak, Christine Z, MacLennan, Gregory T, Flask, Chris A, Lindner, Daniel J, Parker, Yvonne, Daneshgari, Firouz, Gupta, Sanjay

“…Docetaxel chemotherapy remains a standard of care for metastatic castration-resistant prostate cancer (CRPC). Docetaxel modestly increases survival, yet…”
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MiR 208a Regulates Mitochondrial Biogenesis in Metabolically Challenged Cardiomyocytes by Mekala, Naveen, Kurdys, Jacob, Vicenzi, Alexis Paige, Weiler, Leana Rose, Avramut, Carmen, Vazquez, Edwin J, Ragina, Neli, Rosca, Mariana G

“…Metabolic syndrome increases the risk for cardiovascular disease including metabolic cardiomyopathy that may progress to heart failure. The decline in…”
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Neuromuscular recovery from botulism involves multiple forms of compensatory plasticity by Machamer, James B, Vazquez-Cintron, Edwin J, Stenslik, Mallory J, Pagarigan, Kathleen T, Bradford, Aaron B, Ondeck, Celinia A, McNutt, Patrick M

“…Botulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical…”
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Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine by Machamer, James B, Vazquez-Cintron, Edwin J, O'Brien, Sean W, Kelly, Kyle E, Altvater, Amber C, Pagarigan, Kathleen T, Dubee, Parker B, Ondeck, Celinia A, McNutt, Patrick M

“…Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis…”
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Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution by Dyer, Rebekah P., Isoda, Hariny M., Salcedo, Gabriela S., Speciale, Gaetano, Fletcher, Madison H., Le, Linh Q., Liu, Yi, Brami-Cherrier, Karen, Malik, Shiazah Z., Vazquez-Cintron, Edwin J., Chu, Andrew C., Rupp, David C., Jacky, Birgitte P. S., Nguyen, Thu T. M., Katz, Benjamin B., Steward, Lance E., Majumdar, Sudipta, Brideau-Andersen, Amy D., Weiss, Gregory A.

“…The botulinum neurotoxin serotype A (BoNT/A) cuts a single peptide bond in SNAP25, an activity used to treat a wide range of diseases. Reengineering the…”
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Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm by Vazquez-Cintron, Edwin J, Vakulenko, Maksim, Band, Philip A, Stanker, Larry H, Johnson, Eric A, Ichtchenko, Konstantin

“…We have previously described genetic constructs and expression systems that enable facile production of recombinant derivatives of botulinum neurotoxins…”
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Production of reactive oxygen species by mitochondria: central role of complex III by Chen, Qun, Vazquez, Edwin J, Moghaddas, Shadi, Hoppel, Charles L, Lesnefsky, Edward J

“…The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and…”
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Mexican-Origin Youth's Ethnic-Racial Identity Development: The Role of Siblings by Padilla, Jenny, Vazquez, Edwin J., Updegraff, Kimberly A., Umaña-Taylor, Adriana J., McHale, Susan M.

“…Ethnic-racial identity (ERI) formation is an important developmental task. Although families are a primary context for ERI socialization, little is known about…”
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Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells by Vazquez-Cintron, Edwin J, Monu, Ngozi R, Burns, Jeremy C, Blum, Roy, Chen, Gregory, Lopez, Peter, Ma, Jennifer, Radoja, Sasa, Frey, Alan B

“…CD8(+) tumor infiltrating T cells (TIL) lack effector-phase functions due to defective proximal TCR-mediated signaling previously shown to result from…”
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Decrease in Mitochondrial Function in Rat Cardiac Permeabilized Fibers Correlates With the Aging Phenotype by Lemieux, Hélène, Vazquez, Edwin J., Fujioka, Hisashi, Hoppel, Charles L.

“…We measured the loss of cardiac mitochondrial function related to aging in males of three rat strains presenting with different longevity and aging phenotypes:…”
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Three Decades Later: The Life Experiences and Mid-Life Functioning of 1980s Heavy Metal Groupies, Musicians, and Fans by Howe, Tasha R., Aberson, Christopher L., Friedman, Howard S., Murphy, Sarah E., Alcazar, Esperanza, Vazquez, Edwin J., Becker, Rebekah

“…Research in the 1980s suggested that young "metalheads" were at risk for poor developmental outcomes. No other study has assessed this group as adults; thus,…”
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Metabolism of Levulinate in Perfused Rat Livers and Live Rats: CONVERSION TO THE DRUG OF ABUSE 4-HYDROXYPENTANOATE by Harris, Stephanie R, Zhang, Guo-Fang, Sadhukhan, Sushabhan, Murphy, Anne M, Tomcik, Kristyen A, Vazquez, Edwin J, Anderson, Vernon E, Tochtrop, Gregory P, Brunengraber, Henri

“…Calcium levulinate (4-ketopentanoate) is used as an oral and parenteral source of calcium. We hypothesized that levulinate is converted in the liver to…”
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High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction by Rennison, Julie H, McElfresh, Tracy A, Okere, Isidore C, Vazquez, Edwin J, Patel, Hiral V, Foster, Amy B, Patel, Kalpana K, Chen, Qun, Hoit, Brian D, Tserng, Kou-Yi, Hassan, Medhat O, Hoppel, Charles L, Chandler, Margaret P

“…Lipid accumulation in nonadipose tissue due to enhanced circulating fatty acids may play a role in the pathophysiology of heart failure, obesity, and diabetes…”
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Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase by Vazquez-Cintron, Edwin J, Monu, Ngozi R, Frey, Alan B

“…The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response…”
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Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery by Vazquez-Cintron, Edwin J., Beske, Phillip H., Tenezaca, Luis, Tran, Bao Q., Oyler, Jonathan M., Glotfelty, Elliot J., Angeles, Christopher A., Syngkon, Aurelia, Mukherjee, Jean, Kalb, Suzanne R., Band, Philip A., McNutt, Patrick M., Shoemaker, Charles B., Ichtchenko, Konstantin

“…Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is…”
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Production of Reactive Oxygen Species by Mitochondria by Chen, Qun, Vazquez, Edwin J., Moghaddas, Shadi, Hoppel, Charles L., Lesnefsky, Edward J.

“…The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and…”
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