Search Results - "VAWTER, M. P"

Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder by Bunney, B G, Li, J Z, Walsh, D M, Stein, R, Vawter, M P, Cartagena, P, Barchas, J D, Schatzberg, A F, Myers, R M, Watson, S J, Akil, H, Bunney, W E

“…Conventional antidepressants require 2–8 weeks for a full clinical response. In contrast, two rapidly acting antidepressant interventions, low-dose ketamine…”
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The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression by Lavebratt, C, Olsson, S, Backlund, L, Frisén, L, Sellgren, C, Priebe, L, Nikamo, P, Träskman-Bendz, L, Cichon, S, Vawter, M P, Ösby, U, Engberg, G, Landén, M, Erhardt, S, Schalling, M

“…The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF)…”
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A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder by Sellgren, C M, Kegel, M E, Bergen, S E, Ekman, C J, Olsson, S, Larsson, M, Vawter, M P, Backlund, L, Sullivan, P F, Sklar, P, Smoller, J W, Magnusson, P K E, Hultman, C M, Walther-Jallow, L, Svensson, C I, Lichtenstein, P, Schalling, M, Engberg, G, Erhardt, S, Landén, M

“…Elevated cerebrospinal fluid (CSF) levels of the glia-derived N -methyl- D -aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been…”
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Altered Cortical Glutamatergic and GABAergic Signal Transmission with Glial Involvement in Depression by Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J. Z., Vawter, M. P., Myers, R. M., W. E. Bunney, Jr, Akil, H., Watson, S. J., Jones, E. G.

“…Abnormalities in L-glutamic acid (glutamate) and GABA signal transmission have been postulated to play a role in depression, but little is known about the…”
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Prospective association between maternal allostatic load during pregnancy and child mitochondrial content and bioenergetic capacity by Gyllenhammer, L.E., Picard, M., McGill, M.A., Boyle, K.E., Vawter, M.P., Rasmussen, J.M., Buss, C., Entringer, S., Wadhwa, P.D.

“…Mitochondria are multifunctional energy-producing and signaling organelles that support life and contribute to stress adaptation. There is a growing…”
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Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders by VAWTER, M. P, TOMITA, H, WALSH, D. M, BURMEISTER, M, SPEED, T, MYERS, R, JONES, E. G, WATSON, S. J, AKIL, H, BUNNEY, W. E, MENG, F, BOLSTAD, B, LI, J, EVANS, S, CHOUDARY, P, ATZ, M, SHAO, L, NEAL, C

“…Mitochondrial defects in gene expression have been implicated in the pathophysiology of bipolar disorder and schizophrenia. We have now contrasted control…”
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Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder by Mamdani, F, Rollins, B, Morgan, L, Myers, R M, Barchas, J D, Schatzberg, A F, Watson, S J, Akil, H, Potkin, S G, Bunney, W E, Vawter, M P, Sequeira, P A

“…Stress can be a predisposing factor to psychiatric disorders and has been associated with decreased neurogenesis and reduced hippocampal volume especially in…”
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Dysregulation of the Fibroblast Growth Factor System in Major Depression by Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., Walsh, D. M., Myers, R. M., Bunney, W. E., Watson, S. J., Jones, E. G., Akil, H.

“…In this report we describe findings that imply dysregulation of several fibroblast growth factor (FGF) system transcripts in frontal cortical regions of brains…”
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Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia by VAWTER, M. P, THATCHER, L, USEN, N, HYDE, T. M, KLEINMAN, J. E, FREED, W. J

“…Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in…”
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Mitochondrial related gene expression changes are sensitive to agonal-pH state by Vawter, M P, Tomita, H, Meng, F, Bolstad, B, Li, J, Evans, S, Choudary, P, Atz, M, Shao, L, Neal, C, Walsh, D M, Burmeister, M, Speed, T, Myers, R, Jones, E G, Watson, S J, Akil, H, Bunney, W E

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Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia by VAWTER, M. P, HOWARD, A. L, HYDE, T. M, KLEINMAN, J. E, FREED, W. J

“…Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly…”
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The KMO allele encoding Arg 452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression by Lavebratt, C, Olsson, S, Backlund, L, Frisen, L, Sellgren, C, Priebe, L, Nikamo, P, Traskman-Bendz, L, Cichon, S, Vawter, MP

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Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors by Limon, A., Delbruck, E., Yassine, A., Pandya, D., Myers, R. M., Barchas, J. D., Lee, F., Schatzberg, Watson, S. J., Akil, H., Bunney, W. E., Vawter, M. P., Sequeira, A.

“…Polyamines have fundamental roles in brain homeostasis as key modulators of cellular excitability. Several studies have suggested alterations in polyamine…”
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Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA A receptors by Limon, A, Delbruck, E, Yassine, A, Pandya, D, Myers, R M, Barchas, J D, Lee, F, Schatzberg, Watson, S J, Akil, H, Bunney, W E, Vawter, M P, Sequeira, A

“…Polyamines have fundamental roles in brain homeostasis as key modulators of cellular excitability. Several studies have suggested alterations in polyamine…”
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Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse by Lehrmann, E, Oyler, J, Vawter, M P, Hyde, T M, Kolachana, B, Kleinman, J E, Huestis, M A, Becker, K G, Freed, W J

“…CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of…”
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Coding SNPs included in exon arrays for the study of psychiatric disorders by Sequeira, A, Meng, F, Rollins, B, Myers, R M, Jones, E G, Watson, S J, Akil, H, Schatzberg, A F, Barchas, J, Bunney, W E, Vawter, M P

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GRK3 deficiency elicits brain immune activation and psychosis by Sellgren, Carl M., Imbeault, Sophie, Larsson, Markus K., Oliveros, Alfredo, Nilsson, Ida A. K., Codeluppi, Simone, Orhan, Funda, Bhat, Maria, Tufvesson-Alm, Maximilian, Gracias, Jessica, Kegel, Magdalena E., Zheng, Yiran, Faka, Anthi, Svedberg, Marie, Powell, Susan B., Caldwell, Sorana, Kamenski, Mary E., Vawter, Marquis P., Schulmann, Anton, Goiny, Michel, Svensson, Camilla I., Hökfelt, Tomas, Schalling, Martin, Schwieler, Lilly, Cervenka, Simon, Choi, Doo-Sup, Landén, Mikael, Engberg, Göran, Erhardt, Sophie

“…The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder…”
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DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles by Evans, S.J, Choudary, P.V, Vawter, M.P, Li, J, Meador-Woodruff, J.H, Lopez, J.F, Burke, S.M, Thompson, R.C, Myers, R.M, Jones, E.G, Bunney, W.E, Watson, S.J, Akil, H

“…Transcriptional profiles within discrete human brain regions are likely to reflect structural and functional specialization. Using DNA microarray technology,…”
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Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder by Mamdani, F, Rollins, B, Morgan, L, Myers, R M, Barchas, J D, Schatzberg, A F, Watson, S J, Akil, H, Potkin, S G, Bunney, W E, Vawter, M P, Sequeira, P A

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An integrative functional genomics approach for discovering biomarkers in schizophrenia by Vawter, Marquis P., Mamdani, Firoza, Macciardi, Fabio

“…Schizophrenia (SZ) is a complex disorder resulting from both genetic and environmental causes with a lifetime prevalence world-wide of 1%; however, there are…”
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