Search Results - "VATSYAYAN, Rit"

The sensors and regulators of cell–matrix surveillance in anoikis resistance of tumors by Nagaprashantha, Lokesh Dalasanur, Vatsyayan, Rit, Lelsani, Poorna Chandra Rao, Awasthi, Sanjay, Singhal, Sharad S.

“…Normal cells continuously monitor the nature of their respective cellular microenvironment. They are equipped with an inherent molecular defense to detect…”
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Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling by Chaudhary, Pankaj, Sharma, Rajendra, Sharma, Abha, Vatsyayan, Rit, Yadav, Sushma, Singhal, Sharad S, Rauniyar, Navin, Prokai, Laszlo, Awasthi, Sanjay, Awasthi, Yogesh C

“…In recent years, 4-hydroxy-2-nonenal (4-HNE) has emerged as an important second messenger in cell cycle signaling. Here, we demonstrate that 4-HNE induces…”
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RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome by Singhal, Jyotsana, Nagaprashantha, Lokesh, Vatsyayan, Rit, Awasthi, Sanjay, Singhal, Sharad S

“…Characteristic hypoglycemia, hypotriglyceridemia, hypocholesterolemia, lower body mass, and fat as well as pronounced insulin-sensitivity of RLIP76⁻/⁻ mice…”
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Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis by Kothari, Hema, Keshava, Shiva, Vatsyayan, Rit, Mackman, Nigel, Rao, L Vijaya Mohan, Pendurthi, Usha R

“…Tuberculosis (TB) is a chronic lung infectious disease characterized by severe inflammation and lung granulomatous lesion formation. Clinical manifestations of…”
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Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor by Vatsyayan, Rit, Kothari, Hema, Mackman, Nigel, Pendurthi, Usha R, Rao, L Vijaya Mohan

“…Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulator of FVIIa. However, in vitro studies showed that AT could…”
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Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression by Nagaprashantha, Lokesh Dalasanur, Talamantes, Tatjana, Singhal, Jyotsana, Guo, Jia, Vatsyayan, Rit, Rauniyar, Navin, Awasthi, Sanjay, Singhal, Sharad S, Prokai, Laszlo

“…The loss of von Hippel-Lindau (VHL) protein function leads to highly vascular renal tumors characterized by an aggressive course of disease and refractoriness…”
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Role of Lipid Peroxidation in Cellular Responses to d,l-Sulforaphane, a Promising Cancer Chemopreventive Agent by Sharma, Rajendra, Sharma, Abha, Chaudhary, Pankaj, Pearce, Virginia, Vatsyayan, Rit, Singh, Shivendra V, Awasthi, Sanjay, Awasthi, Yogesh C

“…d,l-Sulforaphane (SFN), a synthetic analogue of the broccoli-derived l-isomer, is a highly promising cancer chemopreventive agent substantiated by inhibition…”
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Physiological and Pharmacological Significance of Glutathione-Conjugate Transport by Awasthi, Yogesh C., Chaudhary, Pankaj, Vatsyayan, Rit, Sharma, Abha, Awasthi, Sanjay, Sharma, Rajendra

“…Transport of the glutathione conjugates (GS-E) of electrophilic compounds generated during biotransformation of drugs and environmental pollutants is central…”
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Abstract 526: 4-hydroxy-2-nonenal (HNE), a Lipid Peroxidation Product, Exerts Both Pro- and Anti-thrombotic Effects on Vascular Cells by Kothari, Hema, Vatsyayan, Rit, Rao, Vijaya Mohan

“…Abstract only Background: Oxidative stress and generation of lipid peroxidation (LPO) products are detrimental in the pathogenesis of atherosclerosis and…”
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Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer by Nagaprashantha, Lokesh Dalasanur, Vatsyayan, Rit, Singhal, Jyotsana, Fast, Spence, Roby, Rhonda, Awasthi, Sanjay, Singhal, Sharad S.

“…The present study was conducted to determine the efficacy of novel flavonoid vicenin-2 (VCN-2), an active constituent of the medicinal herb Ocimum Sanctum Linn…”
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4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase Activation-Dependent Phosphatidylserine Exposure by Vatsyayan, Rit, Kothari, Hema, Pendurthi, Usha R, Rao, L. Vijaya Mohan

“…OBJECTIVE—4-hydroxy-2-nonenal (HNE) is one of the major aldehydes formed during lipid peroxidation and is believed to play a role in the pathogenesis of…”
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Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma by Singhal, Jyotsana, Nagaprashantha, Lokesh Dalasanur, Vatsyayan, Rit, Ashutosh, Awasthi, Sanjay, Singhal, Sharad S

“…Neuroblastomas arise from the neural crest cells and represent the most common solid tumors outside the nervous system in children. The amplification of N-Myc…”
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The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4 by Vatsyayan, Rit, Lelsani, Poorna Chandra Rao, Chaudhary, Pankaj, Kumar, Sushil, Awasthi, Sanjay, Awasthi, Yogesh C.

“…► Low concentration of HNE (0.1–1.0μM) induced secretion of VEGF in RPE cells. ► VEGF secreted medium of RPE cells promoted proliferation of endothelial cells…”
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Nutlin-3 enhances sorafenib efficacy in renal cell carcinoma by Vatsyayan, Rit, Singhal, Jyotsana, Nagaprashantha, Lokesh Dalasanur, Awasthi, Sanjay, Singhal, Sharad S.

“…The renal cell carcinoma (RCC) is one of the top 10 cancers in USA. The renal tumors are highly angiogenic and are resistant to conventional interventions,…”
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RLIP76: A versatile transporter and an emerging target for cancer therapy by Vatsyayan, Rit, Lelsani, Poorna Chandra Rao, Awasthi, Sanjay, Singhal, Sharad S.

“…In the last few years, extensive research has been made to elucidate the functional significance of RLIP76. The resulting novel breakthroughs have helped us…”
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Role of Tissue Factor in Mycobacterium Tuberculosis-induced Inflammation and Disease Pathogenesis by Hema, Kothari, Keshava, Shiva, Vatsyayan, Rit, Mackman, Nigel, Pendurthi, Usha R, Rao, L. Vijaya Mohan

“…Tuberculosis, a chronic lung infection caused by Mycobacterium tuberculosis (M.tb), affects nearly one third of the world’s population. Clinical manifestations…”
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4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells by Sharma, Abha, Sharma, Rajendra, Chaudhary, Pankaj, Vatsyayan, Rit, Pearce, Virginia, Jeyabal, Prince V.S., Zimniak, Piotr, Awasthi, Sanjay, Awasthi, Yogesh C.

“…4-Hydroxynonenal (4-HNE) has been suggested to be involved in stress-induced signaling for apoptosis. In present studies, we have examined the effects of 4-HNE…”
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Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase by Vatsyayan, Rit, Roy, Uma

“…Serine hydroxymethyltransferase (SHMT) catalyzes the inter conversion of serine and tetrahydrofolate (H 4-folate) to form glycine and 5,10-methylene H 4-folate…”
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Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis by Singhal, Sharad S, Wickramarachchi, Dilki, Yadav, Sushma, Singhal, Jyotsana, Leake, Kathryn, Vatsyayan, Rit, Chaudhary, Pankaj, Lelsani, Poorna, Suzuki, Sumihiro, Yang, Shaohua, Awasthi, Yogesh C, Awasthi, Sanjay

“…Targeted depletion of the RALBP1-encoded 76-kDa splice variant, RLIP76, causes marked and sustained regression of human xenografts of lung, colon, prostate,…”
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Sterol 24-C-methyltransferase: An enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans by Nes, W. David, Zhou, Wenxu, Ganapathy, Kulothungan, Liu, JiaLin, Vatsyayan, Rit, Chamala, Swetha, Hernandez, Keven, Miranda, Mayra

“…Growth of Cryptococcus neoformans was inhibited by nine nitrogen and sulfur-containing sterols with a heteroatom positioned at C3, C7, C24, C25 or C32 in the…”
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