Search Results - "VARTY, G. B"

Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior by Bleickardt, C. J., Mullins, D. E., MacSweeney, C. P., Werner, B. J., Pond, A. J., Guzzi, M. F., Martin, F. D. C., Varty, G. B., Hodgson, R. A.

“…Rationale Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was…”
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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species by VARTY, G. B, HYDE, L. A, XU, X, KORFMACHER, W. A, TULSHIAN, D, PARKER, E. M, HIGGINS, G. A, HODGSON, R. A, LU, S. X, MCCOOL, M. F, KAZDOBA, T. M, DEL VECCHIO, R. A, GUTHRIE, D. H, POND, A. J, GRZELAK, M. E

“…Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist,…”
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Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs by Varty, G B, Higgins, G A

“…Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA)…”
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Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression by Hodgson, R.A., Higgins, G.A., Guthrie, D.H., Lu, S.X., Pond, A.J., Mullins, D.E., Guzzi, M.F., Parker, E.M., Varty, G.B.

“…Vasopressin and corticotropin releasing factor (CRF) are both critical regulators of an animal's stress response and have been linked to anxiety and…”
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Environmental enrichment and isolation rearing in the rat: effects on locomotor behavior and startle response plasticity by Varty, Geoffrey B, Paulus, Martin P, Braff, David L, Geyer, Mark A

“…Background: Laboratory rats exhibit behavioral changes that reflect a continuum of early life experience, from isolation-reared to socially reared to…”
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M100907, a Serotonin 5-HT2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats by Varty, Geoffrey B, Bakshi, Vaishali P, Geyer, Mark A

“…In a recent study using Wistar rats, the serotonergic 5-HT2 receptor antagonists ketanserin and risperidone reduced the disruptive effects of the…”
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Effects of Isolation Rearing on Startle Reactivity, Habituation, and Prepulse Inhibition in Male Lewis, Sprague-Dawley, And Fischer F344 Rats by Varty, Geoffrey B, Geyer, Mark A

“…This study compared the interaction of strain with isolation rearing on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis,…”
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Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats by Varty, Geoffrey B, Marsden, Charles A, Higgins, Guy A

“…Isolation rearing of rat pups from weaning produces neurochemical and behavioural changes that may have relevance to the neurodevelopmental basis of…”
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Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils by Duffy, R.A., Hedrick, J.A., Randolph, G., Morgan, C.A., Cohen-Williams, M.E., Vassileva, G., Lachowicz, J.E., Laverty, M., Maguire, M., Shan, L.-S., Gustafson, E., Varty, G.B.

“…Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1…”
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Discrepant Findings of Clozapine Effects on Prepulse Inhibition of Startle: Is It the Route or the Rat? by Swerdlow, M.D., Ph.D, Neal R., Varty, Ph.D, Geoffrey B., Geyer, Ph.D, Mark A.

“…Studies examined methodological differences that might account for discrepant reports related to the ability of clozapine to restore prepulse inhibition (PPI)…”
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Is there a critical developmental `window' for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response? by Varty, Geoffrey B, Braff, David L, Geyer, Mark A

“…In a previous study, rats reared in isolation from weaning exhibited normal prepulse inhibition (PPI) before puberty, whilst after puberty (6–8 weeks post…”
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Aging Effects on the Startle Response and Startle Plasticity in Fischer F344 Rats by Varty, G.B, Hauger, R.L, Geyer, M.A

“…The effects of aging on acoustic and airpuff startle reactivity, acoustic and airpuff startle habituation, acoustic and cross-modal (light-acoustic) prepulse…”
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Reversal of a dizocilpine-induced disruption of prepulse inhibition of an acoustic startle response by the 5-HT2 receptor antagonist ketanserin by VARTY, G. B, HIGGINS, G. A

“…Prepulse inhibition can be reliably disrupted by non-competitive NMDA receptor antagonists such as dizocilpine. In recent study, we found that the potent…”
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The genetic liability to stress and postweaning isolation have a competitive influence on behavioral organization in rats by Paulus, Martin P., Varty, Geoffrey B., Geyer, Mark A.

“…Rats housed in social isolation postweaning (isolates) show profound behavioral and neurobiological differences when compared to socially housed rats…”
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Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: Sensitivity to anxiolytic and antidepressant drugs by Hodgson, Robert A., Guthrie, Donald H., Varty, Geoffrey B.

“…Neo-natal rats emit ultrasonic vocalizations (USVs) when isolated from their mothers and littermates. Clinically effective anxiolytics reliably reduce USVs,…”
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Investigations into the nature of a 7-OH-DPAT discriminative cue: Comparison with d-amphetamine by Varty, Geoffrey B, Higgins, Guy A

“…In the present study, separate squads of rats were trained to discriminate either the dopamine D 3 receptor preferring ligand 7-hydroxy-2-(di-…”
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Isolation rearing of mice induces deficits in prepulse inhibition of the startle response by Varty, Geoffrey B., Powell, Susan B., Lehmann-Masten, Virginia, Buell, Mahalah R., Geyer, Mark A.

“…Male 129T2 and C57BL/6J mice were housed either in groups of three (socials) or singly (isolates) at weaning. Six and seven weeks later, prepulse inhibition…”
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Dopamine agonist-induced hypothermia and disruption of prepulse inhibition: evidence for a role of D3 receptors? by Varty, G B, Higgins, G A

“…The dopamine D3/D2 receptor agonists 7-OH-DPAT, quinpirole, quinelorane, and PD128907, the mixed dopamine agonist apomorphine, the D2 agonist bromocriptine,…”
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Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains by Varty, Geoffrey B, Walters, Nafesa, Cohen-Williams, Mary, Carey, Galen J

“…The dopamine agonist apomorphine robustly disrupts prepulse inhibition of the acoustic startle response in the rat, yet published studies have not demonstrated…”
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The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test by Varty, G.B, Cohen-Williams, M.E, Hunter, J.C

“…Recent clinical evidence supports the potential of neurokinin NK1 receptor antagonists as novel antidepressant drugs. A number of NK1 antagonists have reduced…”
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