Search Results - "VARKI, Nissi"

Diversity in cell surface sialic acid presentations: implications for biology and disease by Varki, Nissi M, Varki, Ajit

“…Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface glycoconjugates. They play many important roles in many…”
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Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase by Cohen, Miriam, Zhang, Xing-Quan, Senaati, Hooman P, Chen, Hui-Wen, Varki, Nissi M, Schooley, Robert T, Gagneux, Pascal

“…BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral…”
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Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis by Bard-Chapeau, Emilie A., Li, Shuangwei, Ding, Jin, Zhang, Sharon S., Zhu, Helen H., Princen, Frederic, Fang, Diane D., Han, Tao, Bailly-Maitre, Beatrice, Poli, Valeria, Varki, Nissi M., Wang, Hongyang, Feng, Gen-Sheng

“…The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in…”
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A red meat-derived glycan promotes inflammation and cancer progression by Samraj, Annie N., Pearce, Oliver M. T., Läubli, Heinz, Crittenden, Alyssa N., Bergfeld, Anne K., Banda, Kalyan, Gregg, Christopher J., Bingman, Andrea E., Secrest, Patrick, Diaz, Sandra L., Varki, Nissi M., Varki, Ajit

“…A well known, epidemiologically reproducible risk factor for human carcinomas is the long-term consumption of “red meat” of mammalian origin. Although multiple…”
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Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms by Kawanishi, Kunio, Dhar, Chirag, Do, Raymond, Varki, Nissi, Gordts, Philip L. S. M., Varki, Ajit

“…Cardiovascular disease (CVD) events due to atherosclerosis cause one-third of worldwide deaths and risk factors include physical inactivity, age, dyslipidemia,…”
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On the apparent rarity of epithelial cancers in captive chimpanzees by Varki, Nissi M., Varki, Ajit

“…Malignant neoplasms arising from epithelial cells are called carcinomas. Such cancers are diagnosed in about one in three humans in ‘developed’ countries, with…”
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Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer by Läubli, Heinz, Pearce, Oliver M. T., Schwarz, Flavio, Siddiqui, Shoib S., Deng, Lingquan, Stanczak, Michal A., Deng, Liwen, Verhagen, Andrea, Secrest, Patrick, Lusk, Chrissy, Schwartz, Ann G., Varki, Nissi M., Bui, Jack D., Varki, Ajit

“…Certain pathogenic bacteria are known to modulate the innate immune response by decorating themselves with sialic acids, which can engage the myelomonocytic…”
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Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline by Schwarz, Flavio, Springer, Stevan A., Altheide, Tasha K., Varki, Nissi M., Gagneux, Pascal, Varki, Ajit

“…The individuals of most vertebrate species die when they can no longer reproduce. Humans are a rare exception, having evolved a prolonged postreproductive…”
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Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14 by Fong, Jerry J, Sreedhara, Karthik, Deng, Liwen, Varki, Nissi M, Angata, Takashi, Liu, Qinglian, Nizet, Victor, Varki, Ajit

“…The intracellular chaperone heat‐shock protein 70 (Hsp70) can be secreted from cells, but its extracellular role is unclear, as the protein has been reported…”
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Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid by Banda, Kalyan, Gregg, Christopher J, Chow, Renee, Varki, Nissi M, Varki, Ajit

“…Although N-acetyl groups are common in nature, N-glycolyl groups are rare. Mammals express two major sialic acids, N-acetylneuraminic acid and…”
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Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression by Hedlund, Maria, Padler-Karavani, Vered, Varki, Nissi M, Varki, Ajit

“…Patients with cancer have circulating heterophile antibodies that agglutinate animal red cells via recognition of the mammalian cell surface sialic acid…”
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair by Ma, Jianhui, Benitez, Jorge A., Li, Jie, Miki, Shunichiro, Ponte de Albuquerque, Claudio, Galatro, Thais, Orellana, Laura, Zanca, Ciro, Reed, Rachel, Boyer, Antonia, Koga, Tomoyuki, Varki, Nissi M., Fenton, Tim R., Nagahashi Marie, Suely Kazue, Lindahl, Erik, Gahman, Timothy C., Shiau, Andrew K., Zhou, Huilin, DeGroot, John, Sulman, Erik P., Cavenee, Webster K., Kolodner, Richard D., Chen, Clark C., Furnari, Frank B.

“…Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical…”
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alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo by Hedlund, Maria, Ng, Elisa, Varki, Ajit, Varki, Nissi M

“…Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic…”
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α2-6-Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In vivo by HEDLUND, Maria, NG, Elisa, VARKI, Ajit, VARKI, Nissi M

“…Abstract Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have…”
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Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products by Diaz, Sandra L, Padler-Karavani, Vered, Ghaderi, Darius, Hurtado-Ziola, Nancy, Yu, Hai, Chen, Xi, Brinkman-Van der Linden, Els C M, Varki, Ajit, Varki, Nissi M

“…Humans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from…”
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Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis by Toledo, Alejandro Gómez, Golden, Gregory, Campos, Alexandre Rosa, Cuello, Hector, Sorrentino, James, Lewis, Nathan, Varki, Nissi, Nizet, Victor, Smith, Jeffrey W., Esko, Jeffrey D.

“…Sepsis is a life-threatening condition triggered by a dysregulated host response to microbial infection resulting in vascular dysfunction, organ failure and…”
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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages by Babicky, Michele L., Harper, Megan M., Chakedis, Jeffery, Cazes, Alex, Mose, Evangeline S., Jaquish, Dawn V., French, Randall P., Childers, Betzaira, Alakus, Hakan, Schmid, Michael C., Foubert, Phillippe, Miyamoto, Jaclyn, Holman, Patrick J., Walterscheid, Zakkary J., Tang, Chih-Min, Varki, Nissi, Sicklick, Jason K., Messer, Karen, Varner, Judith A., Waltz, Susan E., Lowy, Andrew M.

“…The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined…”
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Host Adaptation of a Bacterial Toxin from the Human Pathogen Salmonella Typhi by Deng, Lingquan, Song, Jeongmin, Gao, Xiang, Wang, Jiawei, Yu, Hai, Chen, Xi, Varki, Nissi, Naito-Matsui, Yuko, Galán, Jorge E., Varki, Ajit

“…Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid…”
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Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies by Pearce, Oliver M. T., Läubli, Heinz, Verhagen, Andrea, Secrest, Patrick, Zhang, Jiquan, Varki, Nissi M., Crocker, Paul R., Bui, Jack D., Varki, Ajit

“…Compelling evidence for naturally occurring immunosurveillance against malignancies informs and justifies some current approaches toward cancer immunotherapy…”
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Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity by Hartmann, Phillipp, Seebauer, Caroline T, Mazagova, Magdalena, Horvath, Angela, Wang, Lirui, Llorente, Cristina, Varki, Nissi M, Brandl, Katharina, Ho, Samuel B, Schnabl, Bernd

“…Nonalcoholic fatty liver disease (NAFLD) and obesity are characterized by altered gut microbiota, inflammation, and gut barrier dysfunction. Here, we…”
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