Search Results - "VARIN, Jennifer"

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease by Djelti, Fathia, Braudeau, Jerome, Hudry, Eloise, Dhenain, Marc, Varin, Jennifer, Bièche, Ivan, Marquer, Catherine, Chali, Farah, Ayciriex, Sophie, Auzeil, Nicolas, Alves, Sandro, Langui, Dominique, Potier, Marie-Claude, Laprevote, Olivier, Vidaud, Michel, Duyckaerts, Charles, Miles, Richard, Aubourg, Patrick, Cartier, Nathalie

“…Abnormalities in neuronal cholesterol homeostasis have been suspected or observed in several neurodegenerative disorders including Alzheimer's disease,…”
Get full text

The Activation of the WNT Signaling Pathway Is a Hallmark in Neurofibromatosis Type 1 Tumorigenesis by LUSCAN, Armelle, SHACKLEFORD, Ghjuvan'ghjacumu, BORDERIE, Didier, DE RAEDT, Thomas, VALEYRIE-ALLANORE, Laurence, LAROUSSERIE, Frédérique, TERRIS, Benoît, LANTIERI, Laurent, VIDAUD, Michel, VIDAUD, Dominique, WOLKENSTEIN, Pierre, PARFAIT, Béatrice, MASLIAH-PLANCHON, Julien, BIECHE, Ivan, MASSAAD, Charbel, PASMANT, Eric, LAURENDEAU, Ingrid, ORTONNE, Nicolas, VARIN, Jennifer, LALLEMAND, François, LEROY, Karen, DUMAINE, Valérie, HIVELIN, Mikael

“…The hallmark of neurofibromatosis type 1 (NF1) is the onset of dermal or plexiform neurofibromas, mainly composed of Schwann cells. Plexiform neurofibromas can…”
Get full text

MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis by Masliah-Planchon, Julien, Pasmant, Eric, Luscan, Armelle, Laurendeau, Ingrid, Ortonne, Nicolas, Hivelin, Mikael, Varin, Jennifer, Valeyrie-Allanore, Laurence, Dumaine, Valérie, Lantieri, Laurent, Leroy, Karen, Parfait, Béatrice, Wolkenstein, Pierre, Vidaud, Michel, Vidaud, Dominique, Bièche, Ivan

“…Neurofibromatosis type 1 (NF1) is a common dominant tumor predisposition syndrome affecting 1 in 3,500 individuals. The hallmarks of NF1 are the development of…”
Get full text

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis by Ayciriex, Sophie, Djelti, Fathia, Alves, Sandro, Regazzetti, Anne, Gaudin, Mathieu, Varin, Jennifer, Langui, Dominique, Bièche, Ivan, Hudry, Eloise, Dargère, Delphine, Aubourg, Patrick, Auzeil, Nicolas, Laprévote, Olivier, Cartier, Nathalie

“…Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations…”
Get full text

CYP4F2 affects phenotypic outcome in adrenoleukodystrophy by modulating the clearance of very long-chain fatty acids by van Engen, Catherine E., Ofman, Rob, Dijkstra, Inge M.E., van Goethem, Tessa Jacobs, Verheij, Eveline, Varin, Jennifer, Vidaud, Michel, Wanders, Ronald J.A., Aubourg, Patrick, Kemp, Stephan, Barbier, Mathieu

“…X-linked adrenoleukodystrophy (ALD) is a severe neurodegenerative disorder caused by the accumulation of very long-chain fatty acids (VLCFA) due to mutations…”
Get full text

Cutibacterium acnes biofilm formation is influenced by bone microenvironment, implant surfaces and bacterial internalization by Varin-Simon, Jennifer, Colin, Marius, Velard, Frédéric, Tang-Fichaux, Min, Ohl, Xavier, Mongaret, Céline, Gangloff, Sophie C, Reffuveille, Fany

“…The bacterial persistence, responsible for therapeutic failures, can arise from the biofilm formation, which possesses a high tolerance to antibiotics. This…”
Get full text

Infection of Human Dental Pulp Stromal Cells by Streptococcus mutans: Shedding Light on Bacteria Pathogenicity and Pulp Inflammation by Maisonneuve, Elodie, Chevrier, Julie, Dubus, Marie, Varin, Jennifer, Sergheraert, Johan, Gangloff, Sophie C., Reffuveille, Fany, Mauprivez, Cédric, Kerdjoudj, Halima

“…Cariogenic Streptococcus mutans (S. mutans) is implicated in the dental pulp necrosis but also in cardiovascular tissue infections. Herein, the purpose was to…”
Get full text

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: A new approach to prevent and treat bacterial infections by Johnson, Kenneth, Delaney, James C, Guillard, Thomas, Reffuveille, Fany, Varin-Simon, Jennifer, Li, Kai, Wollacott, Andrew, Frapy, Eric, Mong, Surin, Tissire, Hamid, Viswanathan, Karthik, Touti, Faycal, Babcock, Gregory J, Shriver, Zachary, Pentelute, Bradley L, Plante, Obadiah, Skurnik, David

“…The increase in emerging drug resistant Gram-negative bacterial infections is a global concern. In addition, there is growing recognition that compromising the…”
Get full text

NF1 mutations identify molecular and clinical subtypes of lung adenocarcinomas by Tlemsani, Camille, Pécuchet, Nicolas, Gruber, Aurelia, Laurendeau, Ingrid, Danel, Claire, Riquet, Marc, Le Pimpec‐Barthes, Françoise, Fabre, Elizabeth, Mansuet‐Lupo, Audrey, Damotte, Diane, Alifano, Marco, Luscan, Armelle, Rousseau, Benoit, Vidaud, Dominique, Varin, Jennifer, Parfait, Beatrice, Bieche, Ivan, Leroy, Karen, Laurent‐Puig, Pierre, Terris, Benoit, Blons, Helene, Vidaud, Michel, Pasmant, Eric

“…The tumor suppressor gene neurofibromin 1 (NF1) is a major regulator of the RAS‐MAPK pathway. NF1 mutations occur in lung cancer but were not extensively…”
Get full text

Staphylococcus aureus Strain-Dependent Biofilm Formation in Bone-Like Environment by Lamret, Fabien, Varin-Simon, Jennifer, Velard, Frédéric, Terryn, Christine, Mongaret, Céline, Colin, Marius, Gangloff, Sophie C., Reffuveille, Fany

“…Staphylococcus aureus species is an important threat for hospital healthcare because of frequent colonization of indwelling medical devices such as bone and…”
Get full text

Human Osteoblast-Conditioned Media Can Influence Staphylococcus aureus Biofilm Formation by Lamret, Fabien, Varin-Simon, Jennifer, Six, Mélodie, Thoraval, Léa, Chevrier, Julie, Adam, Cloé, Guillaume, Christine, Velard, Frédéric, Gangloff, Sophie C, Reffuveille, Fany

“…Osteoblasts are bone-forming and highly active cells participating in bone homeostasis. In the case of osteomyelitis and more specifically prosthetic joint…”
Get full text

Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain by Reffuveille, Fany, Josse, Jérôme, Velard, Frédéric, Lamret, Fabien, Varin-Simon, Jennifer, Dubus, Marie, Haney, Evan F, Hancock, Robert E W, Mongaret, Céline, Gangloff, Sophie C

“…Prosthesis and joint infections are an important threat in public health, especially due to the development of bacterial biofilms and their high resistance to…”
Get full text

Approaching prosthesis infection environment: Development of an innovative in vitro Staphylococcus aureus biofilm model by Lamret, Fabien, Lemaire, Anaïs, Lagoutte, Manon, Varin-Simon, Jennifer, Abraham, Laura, Colin, Marius, Braux, Julien, Velard, Frédéric, Gangloff, Sophie C., Reffuveille, Fany

“…The major role and implication of bacterial biofilms in the case of bone and prosthesis infections have been highlighted and often linked to implant…”
Get full text

Comparison of Two Cutibacterium acnes Biofilm Models by Varin-Simon, Jennifer, Lamret, Fabien, Colin, Marius, Gangloff, Sophie C., Mongaret, Céline, Reffuveille, Fany

“…The study of biofilms in vitro is complex and often limited by technical problems due to simplified models. Here, we compared C. acnes biofilm formation, from…”
Get full text

Staphylococcus aureus Behavior on Artificial Surfaces Mimicking Bone Environment by Lemaire, Anaïs, Varin-Simon, Jennifer, Lamret, Fabien, Dubus, Marie, Kerdjoudj, Halima, Velard, Frédéric, Gangloff, Sophie C, Reffuveille, Fany

“…Infections, which interfere with bone regeneration, may be a critical issue to consider during the development of biomimetic material. Calcium phosphate (CaP)…”
Get full text

Cutibacterium acnes Biofilm Study during Bone Cells Interaction by Mongaret, Céline, Varin-Simon, Jennifer, Lamret, Fabien, El-Mahdy, Taghrid S., Brasme, Lucien, Vernet-Garnier, Véronique, Gangloff, Sophie C., Ohl, Xavier, Reffuveille, Fany

“…Cutibacterium acnes is an opportunistic pathogen involved in Bone and Prosthesis Infections (BPIs). In this study, we observed the behavior of commensal and…”
Get full text

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology by Burlot, Marie-Anne, Braudeau, Jérôme, Michaelsen-Preusse, Kristin, Potier, Brigitte, Ayciriex, Sophie, Varin, Jennifer, Gautier, Benoit, Djelti, Fathia, Audrain, Mickael, Dauphinot, Luce, Fernandez-Gomez, Francisco-Jose, Caillierez, Raphaëlle, Laprévote, Olivier, Bièche, Ivan, Auzeil, Nicolas, Potier, Marie-Claude, Dutar, Patrick, Korte, Martin, Buée, Luc, Blum, David, Cartier, Nathalie

“…Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The amyloid component and altered cholesterol metabolism are closely linked, but…”
Get full text

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells by Varin, Jennifer, Poulain, Laury, Hivelin, Mikael, Nusbaum, Patrick, Hubas, Arnaud, Laurendeau, Ingrid, Lantieri, Laurent, Wolkenstein, Pierre, Vidaud, Michel, Pasmant, Eric, Chapuis, Nicolas, Parfait, Béatrice

“…Approximately 30-50% of individuals with Neurofibromatosis type 1 develop benign peripheral nerve sheath tumors, called plexiform neurofibromas (PNFs). PNFs…”
Get full text

Interaction of Cutibacterium acnes with human bone marrow derived mesenchymal stem cells: a step toward understanding bone implant- associated infection development by Dubus, M., Varin, J., Papa, S., Rammal, H., Chevrier, J., Maisonneuve, E., Mauprivez, C., Mongaret, C., Gangloff, S.C., Reffuveille, F., Kerdjoudj, H.

“…Crosstalk between mesenchymal stem cells (MSCs) and bacteria plays an important role in regulating the regenerative capacities of MSCs, fighting infections,…”
Get full text

Abstract 5511: Characterization of molecular and functional consequences of somatic NF1 mutations in non-small cell lung cancers by Tlemsani, Camille, Pecuchet, Nicolas, Gruber, Aurélia, Mansuet-Lupo, Audrey, Damotte, Diane, Alifano, Marco, Varin, Jennifer, Laurendeau, Ingrid, Luscan, Armelle, Rousseau, Benoit, Parfait, Beatrice, Bieche, Ivan, Briand, Audrey, Terris, Benoit, Blons, Helene, Leroy, Karen, Vidaud, Dominique, Vidaud, Michel, Laurent-Puig, Pierre, Pasmant, Eric

“…Abstract Driver molecular alterations are found in >20% of non-small cell lung cancers (NSCLCs). They specifically target the RAS-MAPK pathway, including the…”
Get full text