Search Results - "VARGA, S. L"

Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans by VYAS, K. P, HALPIN, R. A, ROGERS, J. D, GEER, L. A, ELLIS, J. D, LIU, L, HAIYUNG CHENG, CHAVEZ-ENG, C, MATUSZEWSKI, B. K, VARGA, S. L, GUIBLIN, A. R

“…The absorption and disposition of rizatriptan (MK-0462, Maxalt(TM)), a selective 5-HT(1B/1D) receptor agonist used in the treatment of migraine headaches, was…”
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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase by Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J

“…Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays…”
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Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans by Balani, S K, Kauffman, L R, Arison, B H, Olah, T V, Goldman, M E, Varga, S L, O'Brien, J A, Ramjit, H G, Rooney, C S, Hoffman, J M

“…Healthy subjects were administered single oral doses of 800 mg or 400 mg 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-o ne (L-696,229), a…”
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Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor by Balani, S K, Goldman, M E, Kauffman, L R, Varga, S L, O'Brien, J A, Smith, S J, Olah, T V, Ramjit, H G, Schorn, T W, Pitzenberger, S M

“…Rhesus monkeys were dosed orally with 10 mg/kg 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005), a nonnucleoside human immunodeficiency virus type 1…”
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Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors by Ponticello, Gerald S, Freedman, Mark B, Habecker, Charles N, Lyle, Paulette A, Schwam, Harvey, Varga, Sandor L, Christy, Marcia E, Randall, William C, Baldwin, John J

“…An attempt to develop a water-soluble carbonic anhydrase inhibitor focused on exploring structure-activity relationships in the thienothiopyransulfonamide…”
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L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity by Sugrue, MF, Gautheron, P, Grove, J, Mallorga, P, Viader, MP, Baldwin, JJ, Ponticello, GS, Varga, SL

“…L-653,328 is the acetate ester of L-652,698 ((S)-3-tert-butylamino-1-[4-[2(hydroxy)ethyl]phenoxy]2-propanol). The penetration of L-652,698 into the albino…”
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Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae) by Witherup, Keith M, Ransom, Richard W, Graham, Amy C, Bernard, Aurora M, Salvatore, Michael J, Lumma, William C, Anderson, Paul S, Pitzenberger, Steven M, Varga, Sandor L

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On the use of the O-methylmandelate ester for establishment of absolute configuration of secondary alcohols by Trost, Barry M, Belletire, John L, Godleski, Stephen, McDougal, Patrick G, Balkovec, James M, Baldwin, John J, Christy, Marcia E, Ponticello, Gerald S, Varga, Sandor L, Springer, James P

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Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human by Prueksaritanont, T, Balani, S K, Dwyer, L M, Ellis, J D, Kauffman, L R, Varga, S L, Pitzenberger, S M, Theoharides, A D

“…In vivo and in vitro metabolism of 6-chloro-4(S)-cyclopropyl-3,4-dihydro-4-((2-pyridyl) ethynyl)quinazolin-2(1H)-one (L-738,372), a potent human…”
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An unusual dimer of 2-mercaptothiophene by Ponticello, Gerald S, Habecker, Charles N, Varga, Sandor L, Pitzenberger, Steven M

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Acetamidomethyl. A Novel Thiol Protecting Group for Cysteine by Veber, Daniel, Milkowski, John, Varga, Sandor, Denkewalter, Robert, Hirschmann, Ralph

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Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2 by Baldwin, J J, Christy, M E, Denny, G H, Habecker, C N, Freedman, M B, Lyle, P A, Ponticello, G S, Varga, S L, Gross, D M, Sweet, C S

“…An attempt to develop a highly cardioselective beta-adrenoceptor antagonist devoid of intrinsic sympathomimetic activity (ISA) focused on exploring…”
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Convenient preparation of substituted 5-aminooxazoles via a microwave-assisted Cornforth rearrangement by Nolt, M. Brad, Smiley, Mark A., Varga, Sandor L., McClain, Ray T., Wolkenberg, Scott E., Lindsley, Craig W.

“…The preparation of oxazole-4-carboxamides and their subsequent thermal rearrangement to 5-aminooxazole-4-carboxylates is optimized in a high-speed…”
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Studies on the total synthesis of an enzyme. V. The preparation of enzymatically active material by Hirschmann, R, Nutt, R F, Veber, D F, Vitali, R A, Varga, S L, Jacob, T A, Holly, F W, Denkewalter, R G

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Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists by Thompson, Wayne J, Anderson, Paul S, Britcher, Susan F, Lyle, Terry A, Thies, J. Eric, Magill, Catherine A, Varga, Sandor L, Schwering, John E, Lyle, Paulette A

“…A series of 73 dibenzo[a,d]cycloalkenimines were synthesized and evaluated for their ability to displace…”
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Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels by Ma, Decheng, Wasylaschuk, Walter R, Beasley, Christopher, Zhao, Zhongxi (Zack), Harmon, Paul A, Ballard, John M, Pitzenberger, Steven M, Varga, Sandor L, Reed, Robert A

“…The purpose of this study was to qualitatively and quantitatively determine potential cellulose acetate butyrate (CAB) extractables in a way to meaningfully…”
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Imino-bridged heterocycles. VII. N-aminobenzocycloheptapyridinimines by Brenner, Daniel G., Pitzenberger, Steven M., Shepard, Kenneth L., Varga, Sandor L.

“…Condensation of anhydrous hydrazine with a variety of benzocycloheptapyridinones led to N‐aminobenzocycloheptapyridinimines. Regiospecific ring closures…”
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Topically active carbonic anhydrase inhibitors. II: Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity by GRAHAM, S. L, SHEPARD, K. L, LYLE, P. A, MICHELSON, S. R, PONTICELLO, G. S, ROBB, C. M, SCHWAM, H, SMITH, A. M, SMITH, R. L, SONDEY, J. M, STROHMAIER, K. M, SUGRUE, M. F, ANDERSON, P. S, VARGA, S. L, BALDWIN, J. J, BEST, D. B, CHRISTY, M. E, FREEDMAN, M. B, GAUTHERON, P, HABECKER, C. N, HOFFMAN, J. M

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β1-Selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2 by BALDWIN, J. J, CHRISTY, M. E, DENNY, G. H, HABECKER, C. N, FREEDMAN, M. B, LYLE, P. A, PONTICELLO, G. S, VARGA, S. L, GROSS, D. M, SWEET, C. S

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Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity by Graham, Samuel L, Shepard, Kenneth L, Anderson, Paul S, Baldwin, John J, Best, Darryl B, Christy, Marcia E, Freedman, Mark B, Gautheron, Pierre, Habecker, Charles N

“…Derivatives of benzo[b]thiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic…”
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