Pulmonary Mycobacterium xenopi infection in non-HIV-infected patients: a systematic review [Review article]

SETTING: The incidence of Mycobacterium xenopi infections is increasing worldwide. The characteristics and optimal management of patients with pulmonary M. xenopi infections have not been well established.METHODS: Systematic review of English- and French-language studies reporting at least two cases...

Full description

Saved in:

Bibliographic Details
Published in:	The international journal of tuberculosis and lung disease Vol. 13; no. 10; pp. 1210 - 1218
Main Authors:	VARADI, R. G, MARRAS, T. K
Format:	Journal Article
Language:	English
Published:	Paris, France IUATLD 01-10-2009 International Union against Tuberculosis and Lung Disease
Subjects:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial diseases Biological and medical sciences Characteristics Drug Female Human bacterial diseases Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Mycobacterium Mycobacterium Infections, Nontuberculous - drug therapy Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium Infections, Nontuberculous - mortality Mycobacterium Xenopi Mycobacterium xenopi - drug effects Mycobacterium xenopi - isolation & purification Pneumology Respiratory system : syndromes and miscellaneous diseases Risk Factors Systematic Review Treatment Treatment Outcome Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - mortality Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Drug Immunopathology characteristics Respiratory disease Lung AIDS Review Mycobacterial infection systematic review Immune deficiency Infection Mycobacterium xenopi Treatment Tuberculosis Mycobacteriales Viral disease Bacteriosis Mycobacteriaceae Bacteria Actinomycetes Bibliographic review Pneumology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	SETTING: The incidence of Mycobacterium xenopi infections is increasing worldwide. The characteristics and optimal management of patients with pulmonary M. xenopi infections have not been well established.METHODS: Systematic review of English- and French-language studies reporting at least two cases of microbiologically confirmed M. xenopi lung infection. Studies were independently reviewed by two reviewers. We described the risk factors and clinical presentation of advanced infection, and examined the impact on clinical success and mortality of including individual antimycobacterial drugs in the treatment regimen.RESULTS: A total of 48 studies reporting on 1255 subjects were included. The majority were retrospective case series. There was marked heterogeneity among the studies. Patients were generally middle-aged men with a history of obstructive lung disease or prior tuberculosis, presenting with an upper lobe cavitary infection. There was no clear association between administration of particular drugs and clinical success or mortality.CONCLUSION: We could not demonstrate any advantage of specific drugs in the treatment of pulmonary M.xenopi infection. Observations from the pooled data are likely subject to significant confounding and selection biases. The inability to make firm conclusions on the optimal management of this increasingly common infection strongly underscores the need for further research.
Bibliography:	(R) Medicine - General 1027-3719(20091001)13:10L.1210;1- ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-4 ObjectType-Undefined-1 ObjectType-Review-2 ObjectType-Article-3
ISSN:	1027-3719 1815-7920