Search Results - "VANDERSLICE, Peter"
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Treatment of hind limb ischemia using angiogenic peptide nanofibers
Published in Biomaterials (01-08-2016)“…Abstract For a proangiogenic therapy to be successful, it must promote the development of mature vasculature for rapid reperfusion of ischemic tissue. Whole…”
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2
A machine learning model to estimate myocardial stiffness from EDPVR
Published in Scientific reports (31-03-2022)“…In-vivo estimation of mechanical properties of the myocardium is essential for patient-specific diagnosis and prognosis of cardiac disease involving myocardial…”
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3
Abstract 5010: Potentiating immune checkpoint blockade therapeutic efficacy using a small molecule activator of integrin cell adhesion receptors
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Background: Immune checkpoint blockade (ICB) has therapeutic benefit in several human cancers, but in many patients, ICB - induced T cells do not…”
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Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk
Published in Frontiers in immunology (08-01-2021)“…Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds…”
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5
Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease
Published in npj vaccines (08-09-2021)“…The development of suitable safe adjuvants to enhance appropriate antigen-driven immune responses remains a challenge. Here we describe the adjuvant properties…”
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CD34⁺/M-cadherin⁺ bone marrow progenitor cells promote arteriogenesis in ischemic hindlimbs of ApoE⁻/⁻ mice
Published in PloS one (03-06-2011)“…Cell-based therapy shows promise in treating peripheral arterial disease (PAD); however, the optimal cell type and long-term efficacy are unknown. In this…”
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7
Affinity and Kinetics of Sialyl Lewis-X and Core-2 Based Oligosaccharides Binding to L- and P-Selectin
Published in Biochemistry (Easton) (12-07-2005)“…Soluble oligosaccharide mimetics of natural selectin ligands act as competitive inhibitors of leukocyte adhesion in models of inflammation. We quantified the…”
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Novel Synthetic Inhibitors of Selectin-Mediated Cell Adhesion: Synthesis of 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-α-d-mannopyranosyloxy)phenyl]hexane (TBC1269)
Published in Journal of medicinal chemistry (26-03-1998)“…Reports of a high-affinity ligand for E-selectin, sialyl di-Lewisx (sLexLex, 1), motivated us to incorporate modifications to previously reported…”
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Abstract Tu048: Viscoelastic remodeling of the left ventricular myocardium in myocardial infarction
Published in Circulation research (02-08-2024)“…Abstract only Introduction. Myocardial infarction (MI) leads to cardiac myocyte death and the formation of a fibrotic scar in the left ventricular myocardium…”
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Abstract 4146917: Role of left ventricular anisotropy in the outcome of myocardial infarction: Insights from a rodent model
Published in Circulation (New York, N.Y.) (12-11-2024)“…Abstract only Introduction: Myocardial infarction (MI) leads to cardiac myocyte death and scarring, resulting in significant biomechanical remodeling of the…”
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Identification of Infarct Border Zone Using Late Gadolinium Enhanced MRI in Rats
Published in The FASEB journal (01-05-2022)“…Background Following acute myocardial infarction (MI), cardiac myocyte death and the formation of a fibrotic scar in the left ventricular free wall (LVFW)…”
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An image-driven micromechanical approach to characterize multiscale remodeling in infarcted myocardium
Published in Acta biomaterialia (01-01-2024)“…Myocardial infarction (MI) is accompanied by the formation of a fibrotic scar in the left ventricle (LV) and initiates significant alterations in the…”
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Abstract 14303: Structural Remodeling in the Left Ventricular Myocardium Underlies Systolic Dysfunction in Myocardial Infarction
Published in Circulation (New York, N.Y.) (16-11-2021)“…IntroductionMyocardial infarction (MI) leads to myofiber death and the formation of a fibrotic scar in the left ventricular free wall (LVFW) myocardium. Acute…”
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Contractile Adaptation of the Left Ventricle Post-myocardial Infarction: Predictions by Rodent-Specific Computational Modeling
Published in Annals of biomedical engineering (01-04-2023)“…Myocardial infarction (MI) results in cardiac myocyte death and the formation of a fibrotic scar in the left ventricular free wall (LVFW). Following an acute…”
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15
Elastic electronics based on micromesh-structured rubbery semiconductor films
Published in Nature electronics (01-12-2022)“…The development of soft electronics that can be seamlessly integrated with biological tissue requires intrinsically stretchable rubbery semiconductors with…”
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LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade
Published in The Journal of clinical investigation (01-07-2022)“…The inability of CD8+ T effectors (Teff) to reach tumor cells is an important mechanism of tumor resistance to cancer immunotherapy. The recruitment of these…”
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A Computational Cardiac Model for the Adaptation to Pulmonary Arterial Hypertension in the Rat
Published in Annals of biomedical engineering (01-01-2019)“…Pulmonary arterial hypertension (PAH) imposes pressure overload on the right ventricle (RV), leading to RV enlargement via the growth of cardiac myocytes and…”
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A Novel Protein with Homology to the Junctional Adhesion Molecule
Published in The Journal of biological chemistry (03-11-2000)“…We have cloned a novel cDNA belonging to the Ig superfamily that shows 44% similarity to the junctional adhesion molecule (JAM) and maps to chromosome 21q21.2…”
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Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1
Published in Scientific reports (27-02-2018)“…Inflammation drives the degradation of atherosclerotic plaque, yet there are no non-invasive techniques available for imaging overall inflammation in…”
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Myosin light chain phosphorylation facilitates monocyte transendothelial migration by dissociating endothelial adherens junctions
Published in Cardiovascular research (01-12-2011)“…Aims Transendothelial migration (TEM) of monocytes is a crucial step in inflammatory processes such as atherogenesis. Tyrosine phosphorylation of vascular…”
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