Search Results - "VANDER BORGHT, Sara"

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma by Marin-Bejar, Oskar, Rogiers, Aljosja, Dewaele, Michael, Femel, Julia, Karras, Panagiotis, Pozniak, Joanna, Bervoets, Greet, Van Raemdonck, Nina, Pedri, Dennis, Swings, Toon, Demeulemeester, Jonas, Borght, Sara Vander, Lehnert, Stefan, Bosisio, Francesca, van den Oord, Joost J., Bempt, Isabelle Vanden, Lambrechts, Diether, Voet, Thierry, Bechter, Oliver, Rizos, Helen, Levesque, Mitchell P., Leucci, Eleonora, Lund, Amanda W., Rambow, Florian, Marine, Jean-Christophe

“…Therapy resistance arises from heterogeneous drug-tolerant persister cells or minimal residual disease (MRD) through genetic and nongenetic mechanisms. A key…”
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Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin by Komuta, Mina, Spee, Bart, Borght, Sara Vander, De Vos, Rita, Verslype, Chris, Aerts, Raymond, Yano, Hirohisa, Suzuki, Tetsuya, Matsuda, Masanori, Fujii, Hideki, Desmet, Valeer J., Kojiro, Masamichi, Roskams, Tania

“…Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic…”
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Reference standards for gene fusion molecular assays on cytological samples: an international validation study by Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, Troncone, Giancarlo

“…Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary…”
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Identification of distinct subgroups of EBV-positive post-transplant diffuse large B-cell lymphoma by Morscio, Julie, Finalet Ferreiro, Julio, Vander Borght, Sara, Bittoun, Emilie, Gheysens, Olivier, Dierickx, Daan, Verhoef, Gregor, Wlodarska, Iwona, Tousseyn, Thomas

“…Post-transplantation lymphoproliferative disorder is an aggressive complication of transplantation, most frequently of diffuse large B-cell lymphoma morphology…”
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Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules by LIBBRECHT, Louis, SEVERI, Tamara, CASSIMAN, David, VANDER BORGHT, Sara, PIRENNE, Jacques, NEVENS, Frederik, VERSLYPE, Chris, VAN PELT, Jos, ROSKAMS, Tania

“…Distinguishing small hepatocellular carcinoma (HCC) from other types of small focal lesions that occur in a cirrhotic liver can be difficult on the basis of…”
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Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel by Froyen, Guy, Le Mercier, Marie, Lierman, Els, Vandepoele, Karl, Nollet, Friedel, Boone, Elke, Van der Meulen, Joni, Jacobs, Koen, Lambin, Suzan, Vander Borght, Sara, Van Valckenborgh, Els, Antoniou, Aline, Hébrant, Aline

“…In most diagnostic laboratories, targeted next-generation sequencing (NGS) is currently the default assay for the detection of somatic variants in solid as…”
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Decreased P‐glycoprotein (P‐gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels by Blokzijl, Hans, Vander Borght, Sara, Bok, Lisette I.H., Libbrecht, Louis, Geuken, Mariska, van den Heuvel, Fiona A.J., Dijkstra, Gerard, Roskams, Tania A.D., Moshage, Han, Jansen, Peter L.M., Faber, Klaas Nico

“…Background: Altered P‐glycoprotein expression (P‐gp/MDR1) and/or function may contribute to the pathogenesis of gastrointestinal inflammatory disorders. Low…”
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Recurrent and novel fusions detected by targeted RNA sequencing as part of the diagnostic workflow of soft tissue and bone tumours by Zago Baltazar, Rafael, Claerhout, Sofie, Vander Borght, Sara, Spans, Lien, Sciot, Raphael, Schöffski, Patrick, Hompes, Daphne, Sinnaeve, Friedl, Wafa, Hazem, Renard, Marleen, van den Hout, Mari FCM, Vernemmen, Astrid, Libbrecht, Louis, De Roo, An‐Katrien, Mazzeo, Filomena, van Marcke, Cédric, Deraedt, Karen, Bourgain, Claire, Vanden Bempt, Isabelle

“…The identification of gene fusions has become an integral part of soft tissue and bone tumour diagnosis. We investigated the added value of targeted RNA‐based…”
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Rapid clinical mutational testing of KRAS , BRAF and EGFR : a prospective comparative analysis of the Idylla technique with high-throughput next-generation sequencing by Van Haele, Matthias, Vander Borght, Sara, Ceulemans, An, Wieërs, Michiel, Metsu, Sofie, Sagaert, Xavier, Weynand, Birgit

“…Precision medicine therapy is remodelling the diagnostic landscape of cancer. The success of these new therapies is often based on the presence or absence of a…”
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Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver by Vander Borght, Sara, Libbrecht, Louis, Blokzijl, Hans, Nico Faber, Klaas, Moshage, Han, Aerts, Raymond, Van Steenbergen, Werner, Jansen, Peter L, Desmet, Valeer J, Roskams, Tania A

“…Hepatocellular adenoma and focal nodular hyperplasia (FNH) are benign liver tumours. The differential diagnosis of these lesions and of well‐ to moderately…”
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Up-regulation of breast cancer resistance protein expression in hepatoblastoma following chemotherapy: A study in patients and in vitro by Vander Borght, Sara, Van Pelt, Jos, Van Malenstein, Hannah, Cassiman, David, Renard, Marleen, Verslype, Chris, Libbrecht, Louis, Roskams, Tania A.

“…Aim:  Hepatoblastoma (HB), the most common pediatric malignant liver tumor, is treated with chemotherapy to facilitate surgical resection. Previous studies…”
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Breast Cancer Resistance Protein (BCRP/ABCG2) Is Expressed by Progenitor Cells/Reactive Ductules and Hepatocytes and Its Expression Pattern Is Influenced by Disease Etiology and Species Type: Possible Functional Consequences by Vander Borght, Sara, Libbrecht, Louis, Katoonizadeh, Aezam, van Pelt, Jos, Cassiman, David, Nevens, Frederik, Van Lommel, Alfons, Petersen, Bryon E, Fevery, Johan, Jansen, Peter L, Roskams, Tania A

“…Breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette transport protein that is expressed in several organs including the liver. Previous…”
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Intra-patient and inter-metastasis heterogeneity of HER2-low status in metastatic breast cancer by Geukens, Tatjana, De Schepper, Maxim, Richard, François, Maetens, Marion, Van Baelen, Karen, Mahdami, Amena, Nguyen, Ha-Linh, Isnaldi, Edoardo, Leduc, Sophia, Pabba, Anirudh, Zels, Gitte, Mertens, Freya, Vander Borght, Sara, Smeets, Ann, Nevelsteen, Ines, Punie, Kevin, Neven, Patrick, Wildiers, Hans, Van Den Bogaert, Wouter, Floris, Giuseppe, Desmedt, Christine

“…Anti-HER2 antibody-drug conjugates (ADCs) have shown important efficacy in HER2-low metastatic breast cancer (mBC). Criteria for receiving ADCs are based on a…”
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Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease by Blokzijl, Hans, van Steenpaal, Axel, Borght, Sara Vander, Bok, Lisette I.H., Libbrecht, Louis, Tamminga, Marieke, Geuken, Mariska, Roskams, Tania A.D., Dijkstra, Gerard, Moshage, Han, Jansen, Peter L.M., Faber, Klaas Nico

“…MRP1 (multidrug resistance-associated protein 1) is well known for its role in providing multidrug resistance to cancer cells. In addition, MRP1 has been…”
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Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling by Spee, Bart, Carpino, Guido, Schotanus, Baukje A, Katoonizadeh, Azeam, Vander Borght, Sara, Gaudio, Eugenio, Roskams, Tania

“…Hepatic progenitor cells (HPCs) hold a great potential for therapeutic intervention for currently untreatable liver diseases. However, in human diseases…”
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Comprehensive targeted next‐generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor by Vanden Bempt, Isabelle, Vander Borght, Sara, Sciot, Raf, Spans, Lien, Claerhout, Sofie, Brems, Hilde, Lehnert, Stefan, Dehaspe, Luc, Fransis, Sabine, Neuville, Bart, Topal, Baki, Schöffski, Patrick, Legius, Eric, Debiec‐Rychter, Maria

“…Mutational analysis guides therapeutic decision making in patients with advanced‐stage gastrointestinal stromal tumors (GISTs). We evaluated three targeted…”
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Comprehensive immunomolecular profiling of endometrial carcinoma: A tertiary retrospective study by Victoor, Jasper, Borght, Sara Vander, Spans, Lien, Lehnert, Stefan, Brems, Hilde, Laenen, Annouschka, Vergote, Ignace, Van Gorp, Toon, Van Nieuwenhuysen, Els, Han, Sileny, Timmerman, Stefan, Van Rompuy, Anne-Sophie, Vanden Bempt, Isabelle

“…Combined immunohistochemical and molecular classification using the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) independently predicts…”
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Targeted RNA sequencing for upfront analysis of actionable driver alterations in non-small cell lung cancer by Claerhout, Sofie, Lehnert, Stefan, Vander Borght, Sara, Spans, Lien, Dooms, Christophe, Wauters, Els, Vansteenkiste, Johan, Weynand, Birgit, Deraedt, Karen, Bourgain, Claire, Vanden Bempt, Isabelle

“…•126 NSCLC samples analyzed by tDNA-seq and tRNA-seq (Archer FusionPlex CTL).•In-house developed bio-IT pipeline key for detection of all variants by…”
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Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells by Sigala, Barbara, McKee, Chad, Soeda, Junpei, Pazienza, Valerio, Morgan, Maelle, Lin, Ching-I, Selden, Clare, Vander Borght, Sara, Mazzoccoli, Gianluigi, Roskams, Tania, Vinciguerra, Manlio, Oben, Jude A

“…Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related…”
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Molecular pathology testing for non-small cell lung cancer: an observational study of elements currently present in request forms and result reports and the opinion of different stakeholders by Dufraing, Kelly, Van Casteren, Kaat, Breyne, Joke, D'Haene, Nicky, Van Campenhout, Claude, Vander Borght, Sara, Zwaenepoel, Karen, Rouleau, Etienne, Schuuring, Ed, von der Thüsen, Jan, Dequeker, Elisabeth

“…Background For patients with non-small cell lung cancer (NSCLC), targeted therapies are becoming part of the standard treatment. It is of question which…”
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