Search Results - "VANDENBARK, A. A"

Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke by Ren, Xuefang, Akiyoshi, Kozaburo, Dziennis, Suzan, Vandenbark, Arthur A, Herson, Paco S, Hurn, Patricia D, Offner, Halina

“…Evaluation of infarct volumes and infiltrating immune cell populations in mice after middle cerebral artery occlusion (MCAO) strongly implicates a mixture of…”
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Microglia and astrocyte involvement in neurodegeneration and brain cancer by Vandenbark, Arthur A, Offner, Halina, Matejuk, Szymon, Matejuk, Agata

“…The brain is unique and the most complex organ of the body, containing neurons and several types of glial cells of different origins and properties that…”
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Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease by Matejuk, Agata, Vandenbark, Arthur A, Offner, Halina

“…The immune system's role is much more than merely recognizing self vs. non-self and involves maintaining homeostasis and integrity of the organism starting…”
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MIF contribution to progressive brain diseases by Matejuk, Agata, Benedek, Gil, Bucala, Richard, Matejuk, Szymon, Offner, Halina, Vandenbark, Arthur A

“…Progressive brain diseases create a huge social and economic burden on modern societies as a major cause of disability and death. Incidence of brain diseases…”
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A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury by Vandenbark, Arthur A, Meza-Romero, Roberto, Benedek, Gil, Offner, Halina

“…Neurovascular, autoimmune, and traumatic injuries of the central nervous system (CNS) all have in common an initial acute inflammatory response mediated by…”
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Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression by Offner, H, Vandenbark, A.A, Hurn, P.D

“…Abstract The profound damage to the CNS caused by ischemic lesions has been well documented. Yet, relatively little is known about the contribution to and…”
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IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke by Bodhankar, Sheetal, Chen, Yingxin, Vandenbark, Arthur A., Murphy, Stephanie J., Offner, Halina

“…Clinical stroke induces inflammatory processes leading to cerebral injury. IL-10 expression is elevated during major CNS diseases and limits inflammation in…”
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Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE by Seifert, Hilary A, Gerstner, Grant, Kent, Gail, Vandenbark, Arthur A, Offner, Halina

“…IL-10 knockout (KO) mice are protected from experimental autoimmune encephalomyelitis (EAE) with low-dose estrogen (E2) treatment similar to wild-type (WT)…”
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Experimental stroke induces massive, rapid activation of the peripheral immune system by Offner, Halina, Subramanian, Sandhya, Parker, Susan M, Afentoulis, Michael E, Vandenbark, Arthur A, Hurn, Patricia D

“…Clinical experimental stroke induces injurious local brain inflammation. However, effects on the peripheral immune system have not been well characterized. We…”
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Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice by Polanczyk, Magdalena J., Hopke, Corwyn, Huan, Jianya, Vandenbark, Arthur A., Offner, Halina

“…Estrogen (E2) upregulates the FoxP3 gene that marks regulatory CD4+CD25+ T cells (Treg cells). However, E2 also inhibits the ability of antigen presenting…”
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Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1 by Wang, Chunhe, Dehghani, Babak, Li, Yuexin, Kaler, Laurie J, Proctor, Thomas, Vandenbark, Arthur A, Offner, Halina

“…Although estrogens exert a pronounced protective effect on multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), their…”
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Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains by Bebo, Bruce F., Jr, Fyfe-Johnson, Amber, Adlard, Kirsten, Beam, Aaron G, Vandenbark, Arthur A, Offner, Halina

“…It has been proposed that homeostatic levels of estrogen can enhance female susceptibility to autoimmunity, whereas the heightened levels of estrogen…”
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PD-L1 Monoclonal Antibody Treats Ischemic Stroke by Controlling Central Nervous System Inflammation by Bodhankar, Sheetal, Chen, Yingxin, Lapato, Andrew, Dotson, Abby L, Wang, Jianming, Vandenbark, Arthur A, Saugstad, Julie A, Offner, Halina

“…BACKGROUND AND PURPOSE—Both pathogenic and regulatory immune processes are involved in the middle cerebral artery occlusion (MCAO) model of experimental…”
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Partial MHC class II constructs as novel immunomodulatory therapy for stroke by Benedek, Gil, Vandenbark, Arthur A., Alkayed, Nabil J., Offner, Halina

“…The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and…”
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Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke by XUEFANG REN, AKIYOSHI, Kozaburo, VANDENBARK, Arthur A, HURN, Patricia D, OFFNER, Halina

“…Evaluation of infarct volumes and infiltrating immune cell populations in mice after middle cerebral artery occlusion strongly implicates a mixture of both…”
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Estradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke by Zhang, Bing, Subramanian, Sandhya, Dziennis, Suzan, Jia, Jia, Uchida, Masayoshi, Akiyoshi, Kozaburo, Migliati, Elton, Lewis, Anne D, Vandenbark, Arthur A, Offner, Halina, Hurn, Patricia D

“…Reduced risk and severity of stroke in adult females is thought to depend on normal endogenous levels of estrogen, a well-known neuroprotectant and…”
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PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1 by Bodhankar, Sheetal, Chen, Yingxin, Vandenbark, Arthur A, Murphy, Stephanie J, Offner, Halina

“…Stroke severity is worsened by recruitment of inflammatory immune cells into the brain. This process depends in part on T cell activation, in which the B7…”
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Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells by Seifert, Hilary A., Benedek, Gil, Nguyen, Ha, Gerstner, Grant, Zhang, Ying, Kent, Gail, Vandenbark, Arthur A., Bernhagen, Jürgen, Offner, Halina

“…A seven day pretreatment course of an oral antibiotic cocktail (Ampicillin, Metronidazole, Neomycin Sulfate, and Vancomycin) was shown to induce changes in…”
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HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis by Meza-Romero, Roberto, Benedek, Gil, Yu, Xiaolin, Mooney, Jeffery L, Dahan, Rony, Duvshani, Nerri, Bucala, Richard, Offner, Halina, Reiter, Yoram, Burrows, Gregory G, Vandenbark, Arthur A

“…CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-mediated diseases as part of…”
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Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen by Seifert, Hilary A., Benedek, Gil, Nguyen, Ha, Kent, Gail, Vandenbark, Arthur A., Offner, Halina

“…Autoimmune diseases including multiple sclerosis predominantly affect females. Although high levels of sex hormones, particularly estrogen (E2), can reduce…”
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