Search Results - "VANBROCKLIN, H. F"

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease by CHRISTINE, C. W, STARR, P. A, LARSON, P. S, EBERLING, J. L, JAGUST, W. J, HAWKINS, R. A, VANBROCKLIN, H. F, WRIGHT, J. F, BANKIEWICZ, K. S, AMINOFF, M. J

“…In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes…”
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[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography by Carroll, V N, Truillet, C, Shen, B, Flavell, R R, Shao, X, Evans, M J, VanBrocklin, H F, Scott, P J H, Chin, F T, Wilson, D M

“…Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and…”
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PET studies of functional compensation in a primate model of Parkinsonʼs disease by Eberling, J L, Bankiewicz, K S, Jordan, S, VanBrocklin, H F, Jagust, W J

“…MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a neurotoxin that produces degeneration of nigrostriatal dopaminergic neurons and a chronic parkinsonian…”
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Dicarboxylic acids as pH sensors for hyperpolarized 13 C magnetic resonance spectroscopic imaging by Korenchan, D E, Taglang, C, von Morze, C, Blecha, J E, Gordon, J W, Sriram, R, Larson, P E Z, Vigneron, D B, VanBrocklin, H F, Kurhanewicz, J, Wilson, D M, Flavell, R R

“…Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2- C,D…”
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A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes by Eberling, Jamie L., Jagust, William J., Taylor, Scott, Bringas, John, Pivirotto, Phillip, VanBrocklin, Henry F., Bankiewicz, Krys S.

“…Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [ 18 F] 6-fluoro- l- m-tyrosine (FMT) were used to evaluate the relationship…”
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Iodine-123-5-Iodo-6-Nitroquipazine: SPECT Radiotracer to Image the Serotonin Transporter by Jagust, William J, Eberling, Jamie L, Biegon, Anat, Taylor, Scott E, VanBrocklin, Henry F, Jordan, Shaun, Hanrahan, Stephen M, Roberts, Jeffrey A, Brennan, Kathleen M, Mathis, Chester A

“…Because serotonergic function has been implicated in the pathophysiology of a number of diseases of the nervous system, efforts to image this system in vivo…”
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20-[18F]Fluoromibolerone, a Positron-Emitting Radiotracer for Androgen Receptors: Synthesis and Tissue Distribution Studies by Liu, Aijun, Katzenellenbogen, John A, VanBrocklin, Henry F, Mathias, Carla J, Welch, Michael J

“…To develop an androgen receptor-based, positron-emitting imaging agent for prostate tumors, we have prepared 20-fluoromibolerone (F-Mib) and evaluated its…”
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Fluorine-18 labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors by Kochanny, Monica J, VanBrocklin, Henry F, Kym, Philip R, Carlson, Kathryn E, O'Neil, James P, Bonasera, Thomas A, Welch, Michael J, Katzenellenbogen, John A

“…We have studied two new fluorine-substituted progestins as potential imaging agents for progesterone-receptor-positive human breast tumors. The steroids are 16…”
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An in vivo microdialysis study of striatal 6-[18F]fluoro-L-m-tyrosine metabolism by JORDAN, S, BANKIEWICZ, K. S, EBERLING, J. L, VANBROCKLIN, H. F, O'NEIL, J. P, JAGUST, W. J

“…In vivo brain microdialysis was used to monitor 6-[18F]fluoro-L-m-tyrosine (FMT) uptake and metabolism in the striatum of conscious freely moving rats for 3…”
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Anilinodialkoxyquinazolines:  Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes by VanBrocklin, Henry F, Lim, John K, Coffing, Stephanie L, Hom, Darren L, Negash, Kitaw, Ono, Michele Y, Gilmore, Jennifer L, Bryant, Ianthe, Riese, David J

“…The epidermal growth factor receptor (EGFR), a long-standing drug development target, is also a desirable target for imaging. Sixteen dialkoxyquinazoline…”
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Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development by Katzenellenbogen, J A, Mathias, C J, VanBrocklin, H F, Brodack, J W, Welch, M J

“…We have measured in vivo the uptake of 16 alpha-[18F]estradiol (FES) by target tissues in the immature rat at increasing dose levels (obtained by dilution of…”
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PET studies of cerebral glucose metabolism in conscious rhesus macaques by Eberling, Jamie L., Roberts, Jeffrey A., De Manincor, Darlene J., Brennan, Kathleen M., Hanrahan, Stephen M., Vanbrocklin, Henry F., Roos, Mark S., Jagust, William J.

“…A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and…”
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Synthesis and Tissue Biodistribution of [.omega.-11C]Palmitic Acid. A Novel Pet Imaging Agent for Cardiac Fatty acid Metabolism by Buckman, Brad O, VanBrocklin, Henry F, Dence, Carmen S, Bergmann, Steven R, Welch, Michael J, Katzenellenbogen, John A

“…In order to diagnose patients with medium-chain acyl-CoA dehydrogenase deficiency with a noninvasive diagnostic technique such as positron emission tomography,…”
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No effect of age and estrogen on aromatic L- amino acid decarboxylase activity in rhesus monkey brain by Eberling, Jamie L., Roberts, Jeffrey A., Taylor, Scott E., VanBrocklin, Henry F., O’Neil, James P., Nordahl, Thomas E.

“…A variety of studies have shown an effect of estrogen on dopamine function and suggest that estrogen may modulate central dopaminergic activity. Positron…”
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16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors by VanBrocklin, H F, Carlson, K E, Katzenellenbogen, J A, Welch, M J

“…In order to understand the structural features that might lead to an estrogen receptor (ER) based breast tumor imaging agent with improved uptake…”
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The synthesis of 7 alpha-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents by VanBrocklin, H F, Liu, A, Welch, M J, O'Neil, J P, Katzenellenbogen, J A

“…The 7 alpha-methyl substituent is reported to increase the binding affinity of estradiol for the estrogen receptor (ER). In order to evaluate whether this…”
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6-[ 18F]Fluoro- l- m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates by Jordan, Shaun, Eberling, Jamie L, Bankiewicz, Krzysztof S, Rosenberg, Daniel, Coxson, Pamela G, VanBrocklin, Henry F, O'Neil, James P, Emborg, Marina E, Jagust, William J

“…The tracer 6-[ 18F]fluoro- l- m-tyrosine (FMT) was studied with regard to its biochemistry and kinetics, as well as its utility in evaluating brain…”
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BEARS: radioactive ion beams at Berkeley by Powell, J, Joosten, R, Donahue, C.A, Fairchild, R.F, Fujisawa, J, Guo, F.Q, Haustein, P.E, Larimer, R.-M, Lyneis, C.M, McMahan, M.A, Moltz, D.M, Norman, E.B, O'Neil, J.P, Ostas, M.A, Rowe, M.W, VanBrocklin, H.F, Wutte, D, Xie, Z.Q, Xu, X.J, Cerny, Joseph

“…A light-isotope radioactive ion-beam capability has been added to the 88-in. Cyclotron at Lawrence Berkeley National Laboratory by coupling to the production…”
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Development of an optimized activatable MMP-14 targeted SPECT imaging probe by Watkins, Gregory A., Jones, Ella Fung, Scott Shell, M., VanBrocklin, Henry F., Pan, Mei-Hsiu, Hanrahan, Stephen M., Feng, Jin Jin, He, Jiang, Sounni, Nor Eddine, Dill, Ken A., Contag, Christopher H., Coussens, Lisa M., Franc, Benjamin L.

“…Design strategy combining computational chemistry, parallel synthesis and protease cleavage studies has yielded a promising MMP-14 sensitive probe for SPECT…”
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16 beta-[18F]fluoromoxestrol: a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors by VanBrocklin, H F, Rocque, P A, Lee, H V, Carlson, K E, Katzenellenbogen, J A, Welch, M J

“…16 beta-[18F]Fluoromoxestrol (beta FMOX, 1) is a highly selective, metabolically stable estrogen with potential as a receptor imaging agent. It demonstrates…”
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