Search Results - "VAN WEYENBERGH, Johan"

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host by Lloréns-Rico, Verónica, Gregory, Ann C., Van Weyenbergh, Johan, Jansen, Sander, Van Buyten, Tina, Qian, Junbin, Braz, Marcos, Menezes, Soraya Maria, Van Mol, Pierre, Vanderbeke, Lore, Dooms, Christophe, Gunst, Jan, Hermans, Greet, Meersseman, Philippe, Wauters, Els, Neyts, Johan, Lambrechts, Diether, Wauters, Joost, Raes, Jeroen

“…Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease…”
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Gene expression profiling-based risk prediction and profiles of immune infiltration in diffuse large B-cell lymphoma by Merdan, Selin, Subramanian, Kritika, Ayer, Turgay, Van Weyenbergh, Johan, Chang, Andres, Koff, Jean L., Flowers, Christopher

“…The clinical risk stratification of diffuse large B-cell lymphoma (DLBCL) relies on the International Prognostic Index (IPI) for the identification of…”
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An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans by Delgobo, Murilo, Mendes, Daniel Agb, Kozlova, Edgar, Rocha, Edroaldo Lummertz, Rodrigues-Luiz, Gabriela F, Mascarin, Lucas, Dias, Greicy, Patrício, Daniel O, Dierckx, Tim, Bicca, Maíra A, Bretton, Gaëlle, Tenório de Menezes, Yonne Karoline, Starick, Márick R, Rovaris, Darcita, Del Moral, Joanita, Mansur, Daniel S, Van Weyenbergh, Johan, Báfica, André

“…Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether ( ) directly regulates myeloid commitment. We demonstrated…”
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Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis by Vivarini, Áislan de Carvalho, Calegari-Silva, Teresa Cristina, Saliba, Alessandra Mattos, Boaventura, Viviane Sampaio, França-Costa, Jaqueline, Khouri, Ricardo, Dierckx, Tim, Dias-Teixeira, Karina Luiza, Fasel, Nicolas, Barral, Aldina Maria Prado, Borges, Valéria Matos, Van Weyenbergh, Johan, Lopes, Ulisses Gazos

“…parasites infect macrophages, causing a wide spectrum of human diseases, from cutaneous to visceral forms. In search of novel therapeutic targets, we performed…”
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Serum GlycA Level is Elevated in Active Systemic Lupus Erythematosus and Correlates to Disease Activity and Lupus Nephritis Severity by Dierckx, Tim, Chiche, Laurent, Daniel, Laurent, Lauwerys, Bernard, Weyenbergh, Johan Van, Jourde-Chiche, Noémie

“…Reliable non-invasive biomarkers are needed to assess disease activity and prognosis in patients with systemic lupus erythematosus (SLE). Glycoprotein…”
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XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis by Boons, Eline, Nogueira, Tatiane C., Dierckx, Tim, Menezes, Soraya Maria, Jacquemyn, Maarten, Tamir, Sharon, Landesman, Yosef, Farré, Lourdes, Bittencourt, Achiléa, Kataoka, Keisuke, Ogawa, Seishi, Snoeck, Robert, Andrei, Graciela, Van Weyenbergh, Johan, Daelemans, Dirk

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CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis by Menezes, Soraya Maria, Decanine, Daniele, Brassat, David, Khouri, Ricardo, Schnitman, Saul V, Kruschewsky, Ramon, López, Giovanni, Alvarez, Carolina, Talledo, Michael, Gotuzzo, Eduardo, Vandamme, Anne-Mieke, Galvão-Castro, Bernardo, Liblau, Roland, Weyenbergh, Johan Van

“…Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic…”
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Inflammatory Gene Expression Profile and Defective Interferon‐γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients by Put, Karen, Vandenhaute, Jessica, Avau, Anneleen, van Nieuwenhuijze, Annemarie, Brisse, Ellen, Dierckx, Tim, Rutgeerts, Omer, Garcia‐Perez, Josselyn E., Toelen, Jaan, Waer, Mark, Leclercq, Georges, Goris, An, Van Weyenbergh, Johan, Liston, Adrian, De Somer, Lien, Wouters, Carine H., Matthys, Patrick

“…Objective Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of…”
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Impact of pulmonary African trypanosomes on the immunology and function of the lung by Mabille, Dorien, Dirkx, Laura, Thys, Sofie, Vermeersch, Marjorie, Montenye, Daniel, Govaerts, Matthias, Hendrickx, Sarah, Takac, Peter, Van Weyenbergh, Johan, Pintelon, Isabel, Delputte, Peter, Maes, Louis, Pérez-Morga, David, Timmermans, Jean-Pierre, Caljon, Guy

“…Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that…”
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Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy? by Subramanian, Kritika, Dierckx, Tim, Khouri, Ricardo, Menezes, Soraya Maria, Kagdi, Huseini, Taylor, Graham P., Farre, Lourdes, Bittencourt, Achilea, Kataoka, Keisuke, Ogawa, Seishi, Van Weyenbergh, Johan

“…Retinoic acid‐related drugs have shown promising pre‐clinical activity in Adult T‐cell Leukemia/Lymphoma, but RORC signaling has not been explored. Therefore,…”
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IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare Workers by Decru, Bram, Van Elslande, Jan, Steels, Sophie, Van Pottelbergh, Gijs, Godderis, Lode, Van Holm, Bram, Bossuyt, Xavier, Van Weyenbergh, Johan, Maes, Piet, Vermeersch, Pieter

“…IgG anti-spike (S) antibodies arise after SARS-CoV-2 infection as well as vaccination. Levels of IgG anti-S are linked to neutralizing antibody titers and…”
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ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis by Dos Santos, Paula Fernandes, Van Weyenbergh, Johan, Delgobo, Murilo, Oliveira Patricio, Daniel de, Ferguson, Brian J, Guabiraba, Rodrigo, Dierckx, Tim, Menezes, Soraya Maria, Báfica, André, Mansur, Daniel Santos

“…IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed to its…”
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A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis by Feys, Simon, Heylen, Jannes, Carvalho, Agostinho, Van Weyenbergh, Johan, Wauters, Joost

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Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19 by Oliveira Formiga, Rodrigo, Amaral, Flávia C., Souza, Camila F., Mendes, Daniel A. G. B., Wanderley, Carlos W. S., Lorenzini, Cristina B., Santos, Adara A., Antônia, Juliana, Faria, Lucas F., Natale, Caio C., Paula, Nicholas M., Silva, Priscila C. S., Fonseca, Fernanda R., Aires, Luan, Heck, Nicoli, Starick, Márick R., Queiroz‐Junior, Celso M., Santos, Felipe R. S., Souza, Filipe R. O., Costa, Vivian V., Barroso, Shana P. C., Morrot, Alexandre, Van Weyenbergh, Johan, Sordi, Regina, Alisson‐Silva, Frederico, Cunha, Fernando Q., Rocha, Edroaldo L., Chollet‐Martin, Sylvie, Hurtado‐Nedelec, Maria Margarita, Martin, Clémence, Burgel, Pierre‐Régis, Mansur, Daniel S., Maurici, Rosemeri, Macauley, Matthew S., Báfica, André, Witko‐Sarsat, Véronique, Spiller, Fernando

“…Background and Purpose Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU)…”
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The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape by Vandermeulen, Charlotte, O'Grady, Tina, Wayet, Jerome, Galvan, Bartimee, Maseko, Sibusiso, Cherkaoui, Majid, Desbuleux, Alice, Coppin, Georges, Olivet, Julien, Ben Ameur, Lamya, Kataoka, Keisuke, Ogawa, Seishi, Hermine, Olivier, Marcais, Ambroise, Thiry, Marc, Mortreux, Franck, Calderwood, Michael A, Van Weyenbergh, Johan, Peloponese, Jean-Marie, Charloteaux, Benoit, Van den Broeke, Anne, Hill, David E, Vidal, Marc, Dequiedt, Franck, Twizere, Jean-Claude

“…Viral infections are known to hijack the transcription and translation of the host cell. However, the extent to which viral proteins coordinate these…”
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Effects of 10-valent pneumococcal conjugate (PCV10) vaccination on the nasopharyngeal microbiome by Salgado, Vanessa R., Fukutani, Kiyoshi F., Fukutani, Eduardo, Lima, João V., Rossi, Erik A., Barral, Aldina, de Oliveira, Camila I., Nascimento-Carvalho, Cristiana, Van Weyenbergh, Johan, Queiroz, Artur T.L.

“…Pathogenic bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae and Moraxella catarrhalis, are important vaccine targets…”
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Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature by Holtz, Andrew, Van Weyenbergh, Johan, Hong, Samuel L, Cuypers, Lize, O'Toole, Áine, Dudas, Gytis, Gerdol, Marco, Potter, Barney I, Ntoumi, Francine, Mapanguy, Claujens Chastel Mfoutou, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Van Holm, Bram, Menezes, Soraya Maria, Soubotko, Katja, Van Pottelbergh, Gijs, Wollants, Elke, Vermeersch, Pieter, Jacob, Ann-Sophie, Maes, Brigitte, Obbels, Dagmar, Matheeussen, Veerle, Martens, Geert, Gras, Jérémie, Verhasselt, Bruno, Laffut, Wim, Vael, Carl, Goegebuer, Truus, van der Kant, Rob, Rousseau, Frederic, Schymkowitz, Joost, Serrano, Luis, Delgado, Javier, Wenseleers, Tom, Bours, Vincent, André, Emmanuel, Suchard, Marc A, Rambaut, Andrew, Dellicour, Simon, Maes, Piet, Durkin, Keith, Baele, Guy

“…We investigate the emergence, mutation profile, and dissemination of SARS-CoV-2 lineage B.1.214.2, first identified in Belgium in January 2021. This variant,…”
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Tumor endothelial cell autophagy is a key vascular‐immune checkpoint in melanoma by Verhoeven, Jelle, Jacobs, Kathryn A, Rizzollo, Francesca, Lodi, Francesca, Hua, Yichao, Poźniak, Joanna, Narayanan Srinivasan, Adhithya, Houbaert, Diede, Shankar, Gautam, More, Sanket, Schaaf, Marco B, Dubroja Lakic, Nikolina, Ganne, Maarten, Lamote, Jochen, Van Weyenbergh, Johan, Boon, Louis, Bechter, Oliver, Bosisio, Francesca, Uchiyama, Yasuo, Bertrand, Mathieu JM, Marine, Jean Christophe, Lambrechts, Diether, Bergers, Gabriele, Agrawal, Madhur, Agostinis, Patrizia

“…Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that…”
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Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation by Assone, Tatiane, Menezes, Soraya Maria, de Toledo Gonçalves, Fernanda, Folgosi, Victor Angelo, da Silva Prates, Gabriela, Dierckx, Tim, Braz, Marcos, Smid, Jerusa, Haziot, Michel E, Marcusso, Rosa M N, Dahy, Flávia E, Vanderlinden, Evelien, Claes, Sandra, Schols, Dominique, Bruhn, Roberta, Murphy, Edward L, Penalva de Oliveira, Augusto César, Daelemans, Dirk, Vercauteren, Jurgen, Casseb, Jorge, Van Weyenbergh, Johan

“…HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy is…”
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IL-10 predicts incident neuroinflammatory disease and proviral load dynamics in a large Brazilian cohort of people living with human T-lymphotropic virus type 1 by Assone, Tatiane, Menezes, Soraya Maria, Gonçalves, Fernanda de Toledo, Folgosi, Victor Angelo, Braz, Marcos, Smid, Jerusa, Haziot, Michel E, Marcusso, Rosa M N, Dahy, Flávia E, de Oliveira, Augusto César Penalva, Vanderlinden, Evelien, Claes, Sandra, Daelemans, Dirk, Vercauteren, Jurgen, Schols, Dominique, Casseb, Jorge, Van Weyenbergh, Johan

“…Human T-Lymphotropic Virus type-1 (HTLV-1) is a unique retrovirus associated with both leukemogenesis and a specific neuroinflammatory condition known as…”
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