Search Results - "VAN Laethem, Jean Luc"

Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study by Bosset, Jean-François, Prof, Calais, Gilles, Prof, Mineur, Laurent, MD, Maingon, Philippe, Prof, Stojanovic-Rundic, Suzana, MD, Bensadoun, René-Jean, Prof, Bardet, Etienne, MD, Beny, Alexander, MD, Ollier, Jean-Claude, MD, Bolla, Michel, Prof, Marchal, Dominique, MD, Van Laethem, Jean-Luc, Prof, Klein, Vincent, MD, Giralt, Jordi, MD, Clavère, Pierre, Prof, Glanzmann, Christoph, Prof, Cellier, Patrice, MD, Collette, Laurence, PhD

“…Summary Background EORTC trial 22921 examined the addition of preoperative or postoperative chemotherapy to preoperative radiotherapy in patients with rectal…”
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An update on treatment options for pancreatic adenocarcinoma by Lambert, Aurélien, Schwarz, Lilian, Borbath, Ivan, Henry, Aline, Van Laethem, Jean-Luc, Malka, David, Ducreux, Michel, Conroy, Thierry

“…Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence, late diagnosis, and limited treatment options, it is expected to…”
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Neoadjuvant chemotherapy associated with isotoxic high‐dose stereotactic body radiotherapy does not increase postoperative complications after pancreaticoduodenectomy for nonmetastatic pancreatic cancer by Navez, Julie, Bouchart, Christelle, Mans, Laura, Devos, Soline, Loi, Patrizia, Closset, Jean, Van Laethem, Jean‐Luc

“…Background and Objectives The role of radiotherapy in the therapeutic sequence of nonmetastatic pancreatic cancer (PC) is controversial, including isotoxic…”
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Phase III Trial Comparing Protracted Intravenous Fluorouracil Infusion Alone or With Yttrium-90 Resin Microspheres Radioembolization for Liver-Limited Metastatic Colorectal Cancer Refractory to Standard Chemotherapy by HENDLISZ, Alain, VAN DEN EYNDE, Marc, DELATTE, Philippe, DELAUNOIT, Thierry, PERSONENI, Nicola, PAESMANS, Marianne, VAN LAETHEM, Jean-Luc, FLAMEN, Patrick, PEETERS, Marc, MALEUX, Geert, LAMBERT, Bieke, VANNOOTE, Jaarke, DE KEUKELEIRE, Katrien, VERSLYPE, Chris, DEFREYNE, Luc, VAN CUTSEM, Eric

“…Liver dissemination is a major cause of mortality among patients with advanced colorectal cancer. Hepatic intra-arterial injection of the beta-emitting isotope…”
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Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1): a single-arm, multicentre phase 1b/2 study by Van Laethem, Jean-Luc, Borbath, Ivan, Prenen, Hans, Geboes, Karen Paula, Lambert, Aurélien, Mitry, Emmanuel, Cassier, Philippe Alexandre, Blanc, Jean-Frédéric, Pilla, Lorenzo, Batlle, Jaime Feliu, Garrote, Mercedes Rodriguez, Pazo-Cid, Roberto Antonio, Gallego, Inmaculada, Smith, Karin Enell, Ellmark, Peter, Pico de Coaña, Yago, Ambarkhane, Sumeet Vijay, Macarulla, Teresa

“…Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We…”
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High‐resolution and quantitative spatial analysis reveal intra‐ductal phenotypic and functional diversification in pancreatic cancer by Michiels, Ellis, Madhloum, Hediel, Van Lint, Silke, Messaoudi, Nouredin, Kunda, Rastislav, Martens, Sandrina, Giron, Philippe, Olsen, Catharina, Lefesvre, Pierre, Dusetti, Nelson, EL Mohajer, Leila, Tomasini, Richard, Hawinkels, Lukas JAC, Ahsayni, Farah, Nicolle, Rémy, Arsenijevic, Tatjana, Bouchart, Christelle, Van Laethem, Jean‐Luc, Rooman, Ilse

“…A ‘classical’ and a ‘basal‐like’ subtype of pancreatic cancer have been reported, with differential expression of GATA6 and different dosages of mutant KRAS…”
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Dataset for the reporting of carcinoma of the exocrine pancreas: recommendations from the International Collaboration on Cancer Reporting (ICCR) by Verbeke, Caroline, Webster, Fleur, Brosens, Lodewijk, Campbell, Fiona, Del Chiaro, Marco, Esposito, Irene, Feakins, Roger M, Fukushima, Noriyoshi, Gill, Anthony J, Kakar, Sanjay, Kench, James G, Krasinskas, Alyssa M, Laethem, Jean‐Luc, Schaeffer, David F, Washington, Kay

“…Aims Current guidelines for pathology reporting on pancreatic cancer differ in certain aspects, resulting in divergent reporting practices and a lack of…”
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Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma by Hilmi, Marc, Cros, Jérôme, Puleo, Francesco, Augustin, Jeremy, Emile, Jean-Francois, Svrcek, Magali, Hammel, Pascal, Arsenijevic, Tatjana, Van Laethem, Jean-Luc, Bachet, Jean-Baptiste, Nicolle, Remy

“…Few patients with pancreatic adenocarcinoma (PAC) are eligible for surgery. Patients with early relapse have a poor prognosis and might be better candidates…”
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Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation by Couck, Marijke De, Maréchal, Raphaël, Moorthamers, Sofie, Laethem, Jean-Luc Van, Gidron, Yori

“…Highlights • The first highlight to reveal in a large sample of patients with a highly fatal cancer, that vagal nerve activity (indexed by heart rate…”
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Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study by Giovannini, Marc, Thomas, Botelberge, Erwan, Bories, Christian, Pesenti, Fabrice, Caillol, Benjamin, Esterni, Geneviève, Monges, Paolo, Arcidiacono, Pierre, Deprez, Robert, Yeung, Walter, Schimdt, Hanz, Schrader, Carl, Szymanski, Christoph, Dietrich, Pierre, Eisendrath, Jean-Luc, Van Laethem, Jacques, Devière, Peter, Vilmann, Andrian, Saftoiu

“…To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. A multicenter study…”
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Cancer patients' behaviors and attitudes toward natural health products by Schils, Audrey, Lechon, Anne-Sophie, Rondeaux, Sarah, Souard, Florence, Van Laethem, Jean-Luc, Pochet, Stephanie, Mathieu, Veronique, De Vriese, Carine

“…Natural health products (NHPs), including vitamins, minerals, and herbal supplements, are the most common complementary and alternative medicine (CAM) among…”
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Missing metastases as a model to challenge current therapeutic algorithms in colorectal liver metastases by Lucidi, Valerio, Hendlisz, Alain, Van Laethem, Jean-Luc, Donckier, Vincent

“…In oncosurgical approach to colorectal liver metastases, surgery remains considered as the only potentially curative option, while chemotherapy alone…”
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Novel strategies using modern radiotherapy to improve pancreatic cancer outcomes: toward a new standard? by Bouchart, Christelle, Navez, Julie, Closset, Jean, Hendlisz, Alain, Van Gestel, Dirk, Moretti, Luigi, Van Laethem, Jean-Luc

“…Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive solid tumours with an estimated 5-year overall survival rate of 7% for all stages…”
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Esophageal cancer: Outcome and potential benefit of esophagectomy in elderly patients by Laurent, Adeline, Marechal, Raphael, Farinella, Eleonora, Bouazza, Fikri, Charaf, Yassine, Gay, France, Van Laethem, Jean‐Luc, Gonsette, Kimberly, El Nakadi, Issam

“…Background This analysis evaluated the morbimortality and the potential benefit of esophagectomy for cancer in elderly patients. Methods Patients who underwent…”
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Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features by Puleo, Francesco, Nicolle, Rémy, Blum, Yuna, Cros, Jérôme, Marisa, Laetitia, Demetter, Pieter, Quertinmont, Eric, Svrcek, Magali, Elarouci, Nabila, Iovanna, Juan, Franchimont, Denis, Verset, Laurine, Galdon, Maria Gomez, Devière, Jacques, de Reyniès, Aurélien, Laurent-Puig, Pierre, Van Laethem, Jean-Luc, Bachet, Jean-Baptiste, Maréchal, Raphaël

“…Genomic studies have revealed subtypes of pancreatic ductal adenocarcinoma (PDA) based on their molecular features, but different studies have reported…”
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A real-world analysis on the efficacy and tolerability of liposomal irinotecan plus 5-fluorouracil and folinic acid in metastatic pancreatic ductal adenocarcinoma in Belgium by Verbruggen, Lise, Verheggen, Lisa, Vanhoutte, Greetje, Loly, Catherine, Lybaert, Willem, Borbath, Ivan, Vergauwe, Philippe, Hendrickx, Koen, Debeuckelaere, Celine, de Haar-Holleman, Amy, Van Laethem, Jean-Luc, Peeters, Marc

“…Background: Currently, nanoliposomal irinotecan (nal-IRI) + 5-fluorouracil/folinic acid (5-FU/LV) is the only approved second-line treatment for patients…”
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Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma by Personeni, Nicola, Giordano, Laura, Abbadessa, Giovanni, Porta, Camillo, Borbath, Ivan, Daniele, Bruno, Van Laethem, Jean-Luc, Van Vlierberghe, Hans, Trojan, Jörg, De Toni, Enrico N, Gasbarrini, Antonio, Lencioni, Monica, Lamar, Maria E, Wang, Yunxia, Shuster, Dale, Schwartz, Brian, Santoro, Armando, Rimassa, Lorenza

“…The ARQ 197-215 study randomized patients to tivantinib or placebo and pre-specified efficacy analyses indicated the predictive value of MET expression as a…”
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Isotoxic high-dose stereotactic body radiotherapy integrated in a total multimodal neoadjuvant strategy for the treatment of localized pancreatic ductal adenocarcinoma by Bouchart, Christelle, Engelholm, Jean-Luc, Closset, Jean, Navez, Julie, Loi, Patrizia, Gökburun, Yeter, De Grez, Thierry, Mans, Laura, Hendlisz, Alain, Bali, Maria Antonietta, Eisendrath, Pierre, Van Gestel, Dirk, Hein, Matthieu, Moretti, Luigi, Van Laethem, Jean-Luc

“…Background: Our aim was to evaluate the feasibility and safety of isotoxic high-dose (iHD) stereotactic body radiation therapy (SBRT) in a total neoadjuvant…”
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What Should Guide the Performance of Venous Resection During Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma with Venous Contact? by Navez, Julie, Bouchart, Christelle, Lorenzo, Diane, Bali, Maria Antonietta, Closset, Jean, van Laethem, Jean-Luc

“…Complete surgical resection, most often associated with perioperative chemotherapy, is the only way to offer a chance of cure for patients with pancreatic…”
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Current standards and new innovative approaches for treatment of pancreatic cancer by Conroy, Thierry, Bachet, Jean-Baptiste, Ayav, Ahmet, Huguet, Florence, Lambert, Aurélien, Caramella, Caroline, Maréchal, Raphaël, Van Laethem, Jean-Luc, Ducreux, Michel

“…Abstract Pancreatic adenocarcinoma remains a devastating disease with a 5-year survival rate not exceeding 6%. Treatment of this disease remains a major…”
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