Search Results - "VAN LIESHOUT, Miriam H. P"

TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis by van Lieshout, Miriam H. P., van der Poll, Tom, van’t Veer, Cornelis

“…Objective and design To investigate the therapeutic effect of E5564 (a clinically used TLR4 inhibitor) in murine abdominal sepsis elicited by intraperitoneal…”
Get full text

Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection by De Jong, Hanna K, Koh, Gavin C K W, van Lieshout, Miriam H P, Roelofs, Joris J T H, van Dissel, Jaap T, van der Poll, Tom, Wiersinga, W Joost

“…The inflammasome is an intracellular protein complex triggered by exposure to intracellular pathogens, its components or other endogenous proteins. It leads to…”
Get full text

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice by Lieshout, Miriam H.P., Vos, Alex F., Dessing, Mark C., Porto, Alexander P.N.A., Boer, Onno J., Beer, Regina, Terpstra, Sanne, Florquin, Sandrine, van't Veer, Cornelis, der Poll, Tom

“…Streptococcus (S.) pneumoniae is the most common cause of community‐acquired pneumonia. The Nod‐like receptor family pyrin domain containing 3 (NLRP3)…”
Get full text

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis by van Lieshout, Miriam H P, Anas, Adam A, Florquin, Sandrine, Hou, Baidong, van't Veer, Cornelis, de Vos, Alex F, van der Poll, Tom

“…Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial…”
Get full text

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia by Anas, Adam A, de Vos, Alex F, Hoogendijk, Arie J, van Lieshout, Miriam HP, van Heijst, Jeroen WJ, Florquin, Sandrine, Li, Zihai, van 't Veer, Cornelis, van der Poll, Tom

“…Klebsiella pneumoniae is among the most common Gram‐negative bacteria that cause pneumonia. Gp96 is an endoplasmic reticulum chaperone that is essential for…”
Get full text

R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae by Hoogendijk, Arie J, Roelofs, Joris J T H, Duitman, Janwillem, van Lieshout, Miriam H P, Blok, Dana C, van der Poll, Tom, Wieland, Catharina W

“…Bacterial pneumonia remains associated with high morbidity and mortality. The gram-positive pathogen Streptococcus pneumoniae is the most common cause of…”
Get full text

Differential Roles of MyD88 and TRIF in Hematopoietic and Resident Cells During Murine Gram-Negative Pneumonia by van Lieshout, Miriam H.P., Blok, Dana C., Wieland, Catharina W., de Vos, Alex F., van 't Veer, Cornelis, van der Poll, Tom

“…Background. Pneumonia is frequently caused by gram-negative pathogens, among which Klebsiella pneumoniae prominently features. Recognition of…”
Get full text

Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo by NIEUWDORP, Max, VAN HAEFTEN, Timon W, KASTELEIN, John J. P, STROES, Erik S. G, GOUVERNEUR, Mirella C. L. G, MOOIJ, Hans L, VAN LIESHOUT, Miriam H. P, LEVI, Marcel, MEIJERS, Joost C. M, HOLLEMAN, Frits, HOEKSTRA, Joost B. L, VINK, Hans

“…Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo Max Nieuwdorp 1 , Timon W…”
Get full text

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis by Birnie, Emma, Weehuizen, Tassili A F, Lankelma, Jacqueline M, de Jong, Hanna K, Koh, Gavin C K W, van Lieshout, Miriam H P, Roelofs, Joris J T H, Budding, Andries E, de Vos, Alex F, van der Poll, Tom, Wiersinga, W Joost

“…The Gram-negative intracellular pathogen is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of…”
Get full text

Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism by Anas, Adam A, van Lieshout, Miriam H P, Claushuis, Theodora A M, de Vos, Alex F, Florquin, Sandrine, de Boer, Onno J, Hou, Baidong, Van't Veer, Cornelis, van der Poll, Tom

“…Pseudomonas aeruginosa is a flagellated pathogen frequently causing pneumonia in hospitalized patients and sufferers of chronic lung disease. Here we…”
Get more information

Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae by Blok, Dana C., van Lieshout, Miriam H.P., Hoogendijk, Arie J., Florquin, Sandrine, de Boer, Onno J., Garlanda, Cecilia, Mantovani, Alberto, van't Veer, Cornelis, de Vos, Alex F., van der Poll, Tom

“…Streptococcus pneumoniae is a common cause of pneumonia and sepsis. Toll-like receptors (TLRs) play a pivotal role in the host defense against infection. In…”
Get full text

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-γ by van Lieshout, Miriam H.P., Florquin, Sandrine, vanʼt Veer, Cornelis, de Vos, Alex F., van der Poll, Tom

“…Klebsiella pneumoniae is an important cause of Gram-negative pneumonia and sepsis. Mice deficient for TIR-domain-containing adaptor-inducing interferon-β…”
Get full text

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-x03B3 by van Lieshout, Miriam H P, Florquin, Sandrine, Vanʼt Veer, Cornelis, de Vos, Alex F, van der Poll, Tom

“…Klebsiella pneumoniae is an important cause of Gram-negative pneumonia and sepsis. Mice deficient for TIR-domain-containing adaptor-inducing interferon-β…”
Get full text

TIR-Domain-Containing Adaptor-Inducing Interferon-[beta] (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-[gamma] by van Lieshout, Miriam HP, Florquin, Sandrine, van't Veer, Cornelis, de Vos, Alex F, van der Poll, Tom

“…Klebsiella pneumoniae is an important cause of Gram-negative pneumonia and sepsis. Mice deficient for TIR-domain-containing adaptor-inducing interferon-β…”
Get full text