Search Results - "VAN HOECK, Arne"

Pan-cancer landscape of homologous recombination deficiency by Nguyen, Luan, W. M. Martens, John, Van Hoeck, Arne, Cuppen, Edwin

“…Homologous recombination deficiency (HRD) results in impaired double strand break repair and is a frequent driver of tumorigenesis. Here, we develop a…”
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Learning mutational signatures and their multidimensional genomic properties with TensorSignatures by Vöhringer, Harald, Hoeck, Arne Van, Cuppen, Edwin, Gerstung, Moritz

“…We present TensorSignatures, an algorithm to learn mutational signatures jointly across different variant categories and their genomic localisation and…”
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The mutational impact of culturing human pluripotent and adult stem cells by Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin

“…Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks…”
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Single-cell derived tumor organoids display diversity in HLA class I peptide presentation by Demmers, Laura C., Kretzschmar, Kai, Van Hoeck, Arne, Bar-Epraïm, Yotam E., van den Toorn, Henk W. P., Koomen, Mandy, van Son, Gijs, van Gorp, Joost, Pronk, Apollo, Smakman, Niels, Cuppen, Edwin, Clevers, Hans, Heck, Albert J. R., Wu, Wei

“…Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where…”
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Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells by Kuijk, Ewart, Jager, Myrthe, van der Roest, Bastiaan, Locati, Mauro D., Van Hoeck, Arne, Korzelius, Jerome, Janssen, Roel, Besselink, Nicolle, Boymans, Sander, van Boxtel, Ruben, Cuppen, Edwin

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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β-Radiation Stress Responses on Growth and Antioxidative Defense System in Plants: A Study with Strontium-90 in Lemna minor by Van Hoeck, Arne, Horemans, Nele, Van Hees, May, Nauts, Robin, Knapen, Dries, Vandenhove, Hildegarde, Blust, Ronny

“…In the following study, dose dependent effects on growth and oxidative stress induced by β-radiation were examined to gain better insights in the mode of…”
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Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features by Nguyen, Luan, Van Hoeck, Arne, Cuppen, Edwin

“…Cancers of unknown primary (CUP) origin account for ∼3% of all cancer diagnoses, whereby the tumor tissue of origin (TOO) cannot be determined. Using a…”
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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity by Sachs, Norman, de Ligt, Joep, Kopper, Oded, Gogola, Ewa, Bounova, Gergana, Weeber, Fleur, Balgobind, Anjali Vanita, Wind, Karin, Gracanin, Ana, Begthel, Harry, Korving, Jeroen, van Boxtel, Ruben, Duarte, Alexandra Alves, Lelieveld, Daphne, van Hoeck, Arne, Ernst, Robert Frans, Blokzijl, Francis, Nijman, Isaac Johannes, Hoogstraat, Marlous, van de Ven, Marieke, Egan, David Anthony, Zinzalla, Vittoria, Moll, Jurgen, Boj, Sylvia Fernandez, Voest, Emile Eugene, Wessels, Lodewyk, van Diest, Paul Joannes, Rottenberg, Sven, Vries, Robert Gerhardus Jacob, Cuppen, Edwin, Clevers, Hans

“…Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for…”
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5-Fluorouracil treatment induces characteristic T>G mutations in human cancer by Christensen, Sharon, Van der Roest, Bastiaan, Besselink, Nicolle, Janssen, Roel, Boymans, Sander, Martens, John W. M., Yaspo, Marie-Laure, Priestley, Peter, Kuijk, Ewart, Cuppen, Edwin, Van Hoeck, Arne

“…5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide…”
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Portrait of a cancer: mutational signature analyses for cancer diagnostics by Van Hoeck, Arne, Tjoonk, Niels H, van Boxtel, Ruben, Cuppen, Edwin

“…In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the…”
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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening by Driehuis, Else, van Hoeck, Arne, Moore, Kat, Kolders, Sigrid, Francies, Hayley E., Gulersonmez, M. Can, Stigter, Edwin C. A., Burgering, Boudewijn, Geurts, Veerle, Gracanin, Ana, Bounova, Gergana, Morsink, Folkert H., Vries, Robert, Boj, Sylvia, van Es, Johan, Offerhaus, G. Johan A., Kranenburg, Onno, Garnett, Mathew J., Wessels, Lodewyk, Cuppen, Edwin, Brosens, Lodewijk A. A., Clevers, Hans

“…We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor…”
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GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing by Cameron, Daniel L, Baber, Jonathan, Shale, Charles, Valle-Inclan, Jose Espejo, Besselink, Nicolle, van Hoeck, Arne, Janssen, Roel, Cuppen, Edwin, Priestley, Peter, Papenfuss, Anthony T

“…GRIDSS2 is the first structural variant caller to explicitly report single breakends-breakpoints in which only one side can be unambiguously determined. By…”
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Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue by Kuijk, Ewart, Kranenburg, Onno, Cuppen, Edwin, Van Hoeck, Arne

“…Genome-wide mutation analyses have revealed that specific anti-cancer drugs are highly mutagenic to cancer cells, but the mutational impact of anti-cancer…”
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MutationalPatterns: the one stop shop for the analysis of mutational processes by Manders, Freek, Brandsma, Arianne M, de Kanter, Jurrian, Verheul, Mark, Oka, Rurika, van Roosmalen, Markus J, van der Roest, Bastiaan, van Hoeck, Arne, Cuppen, Edwin, van Boxtel, Ruben

“…The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be…”
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The genome-wide mutational consequences of DNA hypomethylation by Besselink, Nicolle, Keijer, Janneke, Vermeulen, Carlo, Boymans, Sander, de Ridder, Jeroen, van Hoeck, Arne, Cuppen, Edwin, Kuijk, Ewart

“…DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of…”
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The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time by Rosendahl Huber, Axel, Van Hoeck, Arne, Van Boxtel, Ruben

“…During life, the DNA of our cells is continuously exposed to external damaging processes. Despite the activity of various repair mechanisms, DNA damage…”
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Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision Oncology by van der Wiel, Alexander M. A, Schuitmaker, Lesley, Cong, Ying, Theys, Jan, Van Hoeck, Arne, Vens, Conchita, Lambin, Philippe, Yaromina, Ala, Dubois, Ludwig J

“…Homologous recombination deficiency (HRD) is a prevalent in approximately 17% of tumors and is associated with enhanced sensitivity to anticancer therapies…”
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Characterizing dose response relationships: Chronic gamma radiation in Lemna minor induces oxidative stress and altered polyploidy level by Van Hoeck, Arne, Horemans, Nele, Van Hees, May, Nauts, Robin, Knapen, Dries, Vandenhove, Hildegarde, Blust, Ronny

“…The biological effects and interactions of different radiation types in plants are still far from understood. Among different radiation types, external gamma…”
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Distinct Genomic Profiles Are Associated with Treatment Response and Survival in Ovarian Cancer by de Witte, Chris J, Kutzera, Joachim, van Hoeck, Arne, Nguyen, Luan, Boere, Ingrid A, Jalving, Mathilde, Ottevanger, Petronella B, van Schaik-van de Mheen, Christa, Stevense, Marion, Kloosterman, Wigard P, Zweemer, Ronald P, Cuppen, Edwin, Witteveen, Petronella O

“…The majority of patients with ovarian cancer ultimately develop recurrent chemotherapy-resistant disease. Treatment stratification is mainly based on…”
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Exploration of Atmospheric Pressure Plasma Nanofilm Technology for Straightforward Bio-Active Coating Deposition: Enzymes, Plasmas and Polymers, an Elegant Synergy by Heyse, Pieter, Van Hoeck, Arne, Roeffaers, Maarten B. J., Raffin, Jean-Paul, Steinbüchel, Alexander, Stöveken, Tim, Lammertyn, Jeroen, Verboven, Pieter, Jacobs, Pierre A., Hofkens, Johan, Paulussen, Sabine, Sels, Bert F.

“…While protein or enzyme immobilization methodologies are readily applicable in a majority of industrial processes, some lacunas still remain. For example, the…”
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