Search Results - "VAN HEESWIJK, W"

Strategic bidding in freight transport using deep reinforcement learning by van Heeswijk, W. J. A.

“…This paper presents a multi-agent reinforcement learning algorithm to represent strategic bidding behavior by carriers and shippers in freight transport…”
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Freight consolidation in intermodal networks with reloads by van Heeswijk, W. J. A., Mes, M. R. K., Schutten, J. M. J., Zijm, W. H. M.

“…Intermodal networks offer much flexibility in transport planning, and have the potential to efficiently consolidate goods, even if these goods have distinct…”
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Studies on the roles of GlnK an GlnB in regulating Klebsiella pneumoniae NifL-dependent nitrogen control by Arcondeguy, T, Heeswijk, W.C. van, Merrick, M

“…In Klebsiella pnuemoniae, nitrogen fixation (nif) genes are regulated in response to fixed nitrogen and oxygen. The activity of the nif-specific…”
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Identification of two factors which bind to the upstream sequences of a number of nuclear genes coding for mitochondrial proteins and to genetic elements important for cell division in yeast by DORSMAN, J. C, VAN HEESWIJK, W. C, GRIVELL, L. A

“…Two abundant factors, GFI and GFII which interact with the 5' flanking regions of nuclear genes coding for proteins of the mitochondrial respiratory chain have…”
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Macromolecular intelligence in microorganisms by Bruggeman, F J, van Heeswijk, W C, Boogerd, F C, Westerhoff, H V

“…Biochemistry and molecular biology have been focusing on the structural, catalytic, and regulatory properties of individual macromolecules from the perspective…”
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The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli by van Heeswijk, W C, Rabenberg, M, Westerhoff, H V, Kahn, D

“…Regulation of glutamine-synthetase (GS) activity in enteric bacteria involves a complex cascade of events. In response to nitrogen limitation, a transferase…”
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Yeast general transcription factor GFI : sequence requirements for binding to DNA and evolutionary conservation by DORSMAN, J. C, VAN HEESWIJK, W. C, GRIVELL, L. A

“…GFI is an abundant DNA binding protein in the yeast S. cerevisiae. The protein binds to specific sequences in both ARS elements and the upstream regions of a…”
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Signal transduction to the Azotobacter vinelandii NIFL-NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein by Little, Richard, Reyes-Ramirez, Francisca, Zhang, Yan, van Heeswijk, Wally C., Dixon, Ray

“…PII‐like signal transduction proteins, which respond to the nitrogen status via covalent modification and signal the carbon status through the binding of…”
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Live control of the living cell by van Heeswijk, W C, Bakker, B M, Teusink, B, Kholodenko, B N, Somsen, O J, Snoep, J L, Westerhoff, H V

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An urban consolidation center in the city of Copenhagen: A simulation study by van Heeswijk, Wouter, Larsen, Rune, Larsen, Allan

“…Urban consolidation centers (UCCs) have a key role in many initiatives in urban logistics, yet few of them are successful in the long run. The high costs often…”
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Multi-functional DNA proteins in yeast: the factors GFI and GFII are identical to the ARS-binding factor ABFI and the centromere-binding factor CPF1 respectively by Dorsman, J C, Gozdzicka-Jozefiak, A, van Heeswijk, W C, Grivell, L A

“…GFI and GFII are abundant DNA-binding proteins in the yeast Saccharomyces cerevisiae. Binding sites for GFI conform to the sequence 5'-RTCRYNNNNNACG-3'. This…”
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The two opposing activities of adenylyl transferase reside in distinct homologous domains, with intramolecular signal transduction by Jaggi, Rene, van Heeswijk, Wally C., Westerhoff, Hans V., Ollis, David L., Vasudevan, Subhash G.

“…Adenylyl transferase (ATase) is the bifunctional effector enzyme in the nitrogen assimilation cascade that controls the activity of glutamine synthetase (GS)…”
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Does infrapatellar fat pad resection in total knee arthroplasty impair clinical outcome? A systematic review by Van Beeck, A, Clockaerts, S, Somville, J, Van Heeswijk, J.H.W, Van Glabbeek, F, Bos, P.K, Reijman, M

“…Abstract Introduction The infrapatellar fat pad (IPFP) is often removed during total knee arthroplasty (TKA). No evidence based guidelines on changes in…”
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The Escherichia coli Signal Transducers PII (GlnB) and GlnK form Heterotrimers in vivo: Fine Tuning the Nitrogen Signal Cascade by van Heeswijk, Wally C., Wen, Daying, Clancy, Paula, Jaggi, Rene, Ollis, David L., Westerhoff, Hans V., Vasudevan, Subhash G.

“…The PII protein is Escherichia coli's cognate transducer of the nitrogen signal to the NRII (NtrB)/NRI (NtrC) two-component system and to adenylyltransferase…”
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An additional PII in Escherichia coli: a new regulatory protein in the glutamine synthetase cascade by van Heeswijk, W C, Stegeman, B, Hoving, S, Molenaar, D, Kahn, D, Westerhoff, H V

“…The PII protein in the glutamine synthetase cascade transduces the nitrogen signal, as sensed by uridylyltransferase, both to the NRII/NRI two-component system…”
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Crystallization and preliminary X-ray analysis of Escherichia coli GlnK by Macpherson, Kirsty H. R., Xu, Yibin, Cheah, Eong, Carr, Paul D., Van Heeswijk, Wally C., Westerhoff, Hans V., Luque, Eva, Vasudevan, Subhash G., Ollis, David L.

“…The trimeric signal‐transduction protein GlnK, from Escherichia coli, has been over‐expressed, purified to homogeneity and crystallized. The crystals belong to…”
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Localization of the glnD gene on a revised map of the 200-kilobase region of the Escherichia coli chromosome by VAN HEESWIJK, W, KUPPINGER, O, MERRICK, M, KAHN, D

“…To identify the physical location of glnD, we made use of a glnD::Tn10 insertion in strain RB9040 (3). Southern blotting of PstI-, EcoRI-, and…”
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Natural Policy Gradients In Reinforcement Learning Explained by van Heeswijk, W. J. A

“…Traditional policy gradient methods are fundamentally flawed. Natural gradients converge quicker and better, forming the foundation of contemporary…”
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Molecular biology for flux control by Jensen, P R, Snoep, J L, Molenaar, D, van Heeswijk, W C, Kholodenko, B N, van der Gugten, A A, Westerhoff, H V

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A Gentle Lecture Note on Filtrations in Reinforcement Learning by van Heeswijk, W. J. A

“…This note aims to provide a basic intuition on the concept of filtrations as used in the context of reinforcement learning (RL). Filtrations are often used to…”
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