Search Results - "VAN HAVER, Dirk"

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α, 25-dihydroxyvitamin D3: Spiro[5.5]undecane CF-ring analogues by SCHEPENS, Wim, VAN HAVER, Dirk, VANDEWALLE, Maurits, DE CLERCQ, Pierre J, BOUILLON, Roger, VERSTUYF, Annemieke

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Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α, 25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues by DEMIN, Samuël, VAN HAVER, Dirk, VANDEWALLE, Maurits, DE CLERCQ, Pierre J, BOUILLON, Roger, VERSTUYF, Annemieke

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Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues by Schepens, Wim, Van Haver, Dirk Van, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a…”
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Previtamin D3 with a trans-Fused Decalin CD-ring Has Pronounced Genomic Activity by Verlinden, Lieve, Verstuyf, Annemieke, Verboven, Christel, Eelen, Guy, De Ranter, Camiel, Gao, Ling-Jie, Chen, Yong-Jun, Murad, Ibrahim, Choi, Mihwa, Yamamoto, Keiko, Yamada, Sachiko, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J., Bouillon, Roger

“…Deletion of C19 in the structure of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] does not substantially alter the biological potency but prevents the conversion…”
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Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof by Demin, Samuël, Van Haver, Dirk, De Clercq, Pierre J

“…The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are…”
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A Short Intramolecular Diels−Alder Route to Himbacine Derivatives by Hofman, Sven, Gao, Ling-Jie, Van Dingenen, Hilde, Hosten, Noël G. C., Van Haver, Dirk, De Clercq, Pierre J., Milanesio, Marco, Viterbo, Davide

“…The intramolecular cycloaddition of 5 yields the unsaturated lactones 17a, 17b, and 17c as three major isomeric adducts. These were further reduced to the…”
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Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists by Gao, Ling-Jie, Waelbroeck, Magali, Hofman, Sven, Van Haver, Dirk, Milanesio, Marco, Viterbo, Davide, De Clercq, Pierre J

“…A series of himbacine ( 1)-related analogues has been prepared featuring three different isomeric configurations with respect to the B-ring ( a, b and natural…”
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Synthesis and binding affinity studies of muscarinic receptor antagonists related to dehydrohimbacine by Gao, Ling-Jie, Cauwenberge, Gunther Van, Hosten, Noël, Haver, Dirk Van, Waelbroeck, Magali, Clercq, Pierre J. De

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Permeability of the blood-brain barrier for atenolol studied by positron emission tomography by Agon, P, Goethals, P, Van Haver, D, Kaufman, J M

“…The permeability of the blood-brain barrier for atenolol, a hydrophilic beta-adrenergic blocking agent, has been assessed in dogs, by studying the distribution…”
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Synthesis of Spiro[4.5]decane CF-Ring Analogues of 1α,25-Dihydroxyvitamin D 3 by Schepens, Wim, Van Haver, Dirk, Vandewalle, Maurits, Bouillon, Roger, Verstuyf, Annemieke, De Clercq, Pierre J.

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Development of Analogues of 1α,25‐Dihydroxyvitamin D 3 with Biased Side‐Chain Orientation: C20 Methylated Des‐C,D‐homo Analogues by Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verlinden, Lieve, Verstuyf, Annemieke, Bouillon, Roger, Croce, Gianluca, De Clercq, Pierre

“…Abstract The discovery that 1α,25‐dihydroxyvitamin D 3 is effective in the inhibition of cellular proliferation and in the induction of cellular…”
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Synthesis of Spiro[4.5]decane CF-Ring Analogues of 1α,25-Dihydroxyvitamin D3 by Schepens, Wim, Van Haver, Dirk, Vandewalle, Maurits, Bouillon, Roger, Verstuyf, Annemieke, De Clercq, Pierre J

“…A novel series of analogues of calcitriol (1) is developed featuring a spirocyclic central core resulting from C18/C21-connection and C15/C16-deletion (2a,…”
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Development of Analogues of la,25-Dihydroxyvitamin D3 with Biased Side-Chain Orientation : C20 Methylated Des-C,D-homo Analogues by VRIELYNCK, Freek, VAN HAVER, Dirk, VANDEWALLE, Maurits, VERLINDEN, Lieve, VERSTUYF, Annemieke, BOUILLON, Roger, CROCE, Gianluca, DE CLERCQ, Pierre

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The development of CD-ring modified analogs of 1α,25-dihydroxyvitamin D by De Clercq, Pierre J., De Buysser, Frederik, Minne, Garrett, Schepens, Wim, Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verstuyf, Annemieke, Bouillon, Roger

“…During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural…”
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Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs by Chen, Yong-Jun, Gao, Ling-Jie, Murad, Ibrahim, Verstuyf, Annemieke, Verlinden, Lieve, Verboven, Christel, Bouillon, Roger, Viterbo, Davide, Milanesio, Marco, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J

“…A novel series of analogs of 1,25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, characterised by the presence of a trans-fused decalin…”
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The development of CD-ring modified analogs of 1alpha,25-dihydroxyvitamin D by De Clercq, Pierre J, De Buysser, Frederik, Minne, Garrett, Schepens, Wim, Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verstuyf, Annemieke, Bouillon, Roger

“…During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural…”
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Development of Analogues of 1α,25-Dihydroxyvitamin D3 with Biased Side Chain Orientation: Methylated Des-C,D-Homo Analogues by Gabriëls, Stefan, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre, Verstuyf, Annemieke, Bouillon, Roger

“…The discovery that 1α,25‐dihydroxyvitamin D3 is effective in the inhibition of cellular proliferation and in the induction of cellular differentiation has led…”
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Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues by Demin, Samuël, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a…”
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Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α,25-dihydroxyvitamin D 3: spiro[5.5]undecane CF-ring analogues by Schepens, Wim, Haver, Dirk Van, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CF-ring 22-oxa-1α,25(OH) 2D 3 analogues is described. The synthesis and biological activity of novel CD-ring…”
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Biological Activity of CD‐Ring Modified 1α,25‐Dihydroxyvitamin D Analogues: C‐Ring and Five‐Membered D‐Ring Analogues by Verstuyf, Annemieke, Verlinden, Lieve, Van Etten, Evelyne, Shi, Ling, Wu, Yusheng, D'Halleweyn, Chris, Van Haver, Dirk, Zhu, Gui‐Dong, Chen, Yong‐Jun, Zhou, Xiaoming, Haussler, Mark R., De Clercq, Pierre, Vandewalle, Maurits, Van Baelen, Hugo, Mathieu, Chantal, Bouillon, Roger

“…Nonsteroidal analogues of 1α,25(OH)2D3, lacking either the full five‐membered D ring (C‐ring analogues) or the full six‐membered C ring (D‐ring analogues) are…”
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