Search Results - "VAN GOIETSENOVEN, Gwendoline"
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In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells
Published in Journal of natural products (Washington, D.C.) (27-09-2013)“…Eight cyclic peroxide norterpenoids, compounds 1–8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new…”
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Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers
Published in Medicinal research reviews (01-03-2013)“…The anticancer activity of Amaryllidaceae isocarbostyrils is well documented. At pharmacological concentrations, that is, approximately 1 μM in vitro and…”
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Amaryllidaceae Alkaloids Belonging to Different Structural Subgroups Display Activity against Apoptosis-Resistant Cancer Cells
Published in Journal of natural products (Washington, D.C.) (23-07-2010)“…Fifteen Amaryllidaceae alkaloids (1−15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural…”
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In vitro growth inhibitory effects of cytochalasins and derivatives in cancer cells
Published in Planta medica (01-05-2011)“…The in vitro anticancer activity of eight natural cytochalasins and three hemisynthetic derivatives of cytochalasin B on six cancer cell lines was evaluated…”
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Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells
Published in Molecular cancer therapeutics (01-07-2009)“…Cell motility and resistance to apoptosis characterize glioblastoma multiforme growth and malignancy. Narciclasine, a plant growth modulator, could represent a…”
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Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight
Published in Journal of medicinal chemistry (22-10-2009)“…Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using four cancer cell lines displaying different levels of resistance…”
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Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas
Published in The FASEB journal (01-11-2010)“…Melanomas display poor response rates to adjuvant therapies because of their intrinsic resistance to proapoptotic stimuli. This study indicates that such…”
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Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes
Published in Journal of investigative dermatology (01-09-2012)“…Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles,…”
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In vitro anticancer activity, toxicity and structure–activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii
Published in Toxicology and applied pharmacology (01-07-2011)“…The in vitro anticancer activity and toxicity of phyllostictine A, a novel oxazatricycloalkenone recently isolated from a plant-pathogenic fungus (…”
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JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation
Published in Translational oncology (01-06-2011)“…Abstract Gliomas account for 5% to 7% of all solid cancers in adults and up to 30% of solid cancers in children; glioblastomas are the most malignant type of…”
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Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight
Published in Journal of medicinal chemistry (22-10-2009)“…Twenty-two lycorine-related compounds were investigated for in vitro anti-tumor activity using four cancer cell lines displaying different levels of resistance…”
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Bis-8-hydroxyquinoline and bis-8-hydroxyquinaldine N-substituted amines: A single methyl group structural difference between the two heterocycles, which modulates the antiproliferative effects
Published in Journal of heterocyclic chemistry (01-05-2010)“…The synthesis of a series of bis‐8‐hydroxyquinoline‐ and bis‐8‐hydroxyquinaldine‐substituted N‐benzyl or thiophenyl amines and their corresponding…”
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New ursane-type triterpenes from the root bark of Calotropis procera
Published in Phytochemistry letters (01-09-2012)“…[Display omitted] ► The cytotoxic n-hexane fraction of the root bark of Calotropis procera was investigated. ► This study reports the isolation of four new and…”
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JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation12
Published in Translational oncology (01-06-2011)“…Gliomas account for 5% to 7% of all solid cancers in adults and up to 30% of solid cancers in children; glioblastomas are the most malignant type of glioma and…”
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