Search Results - "VAN GINKEL, Paul R"

Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration by Clark, Paul A, Bhattacharya, Saswati, Elmayan, Ardem, Darjatmoko, Soesiawati R, Thuro, Bradley A, Yan, Michael B, van Ginkel, Paul R, Polans, Arthur S, Kuo, John S

“…OBJECTIVE Glioblastoma multiforme (GBM) is an aggressive brain cancer with median survival of less than 2 years with current treatment. Glioblastomas exhibit…”
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Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis by Flynn, Corey G K, Ginkel, Paul R Van, Hubert, Katharine A, Guo, Qingyuan, Hrycaj, Steven M, McDermott, Aubrey E, Madruga, Angelo, Miller, Anna P, Wellik, Deneen M

“…Interstitial stromal cells play critical roles in muscle development, regeneration and repair and we have previously reported that Hoxa11 and Hoxd11 are…”
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Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance by Scariot, Pedro Paulo Menezes, Papoti, Marcelo, Polisel, Emanuel Elias Camolese, Orsi, Juan Bordon, Van Ginkel, Paul R., Prolla, Tomas A., Manchado-Gobatto, Fúlvia Barros, Gobatto, Claudio Alexandre

“…There is a scarcity of data regarding the acclimation to high altitude (hypoxic environment) accompanied by training at low altitude (normoxic conditions), the…”
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Resveratrol Inhibits Tumor Growth of Human Neuroblastoma and Mediates Apoptosis by Directly Targeting Mitochondria by VAN GINKEL, Paul R, SAREEN, Dhruv, SUBRAMANIAN, Lalita, WALKER, Quintisha, DARJATMOKO, Soesiawati R, LINDSTROM, Mary J, KULKARNI, Amol, ALBERT, Daniel M, POLANS, Arthur S

“…Purpose: Neuroblastoma is an aggressive childhood disease of the sympathetic nervous system. Treatments are often ineffective and have serious side effects…”
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Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells by van Ginkel, Paul R., Yan, Michael B., Bhattacharya, Saswati, Polans, Arthur S., Kenealey, Jason D.

“…Paclitaxel, etoposide, vincristine and doxorubicin are examples of natural products being used as chemotherapeutics but with adverse side effects that limit…”
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Mitochondria as the Primary Target of Resveratrol-Induced Apoptosis in Human Retinoblastoma Cells by Sareen, Dhruv, van Ginkel, Paul R, Takach, Jennifer C, Mohiuddin, Ayesha, Darjatmoko, Soesiawati R, Albert, Daniel M, Polans, Arthur S

“…To determine the molecular mechanisms by which resveratrol induces retinoblastoma tumor cell death. After resveratrol treatment, Y79 tumor cell viability was…”
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The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Hox5 Function by Li, Mu-Hang, Marty-Santos, Leilani M, van Ginkel, Paul R, McDermott, Aubrey E, Rasky, Andrew J, Lukacs, Nicholas W, Wellik, Deneen M

“…genes encode transcription factors that are critical for embryonic skeletal patterning and organogenesis. The , , and paralogs are expressed in the lung…”
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The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization by Kanavi, Mozhgan Rezaie, Darjatmoko, Soesiawati, Wang, Shoujian, Azari, Amir A, Farnoodian, Mitra, Kenealey, Jason D, van Ginkel, Paul R, Albert, Daniel M, Sheibani, Nader, Polans, Arthur S

“…The objective of this study was to determine whether resveratrol or a defined, reconstituted grape powder can attenuate the formation of new blood vessels in a…”
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Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival by VAN GINKEL, Paul R, GEE, Ricardo L, SHEARER, Rebecca L, SUBRAMANIAN, Lalita, WALKER, Teresa M, ALBERT, Daniel M, MEISNER, Lorraine F, VARNUM, Brian C, POLANS, Arthur S

“…Metastatic tumor cells originating from cancers of a variety of tissues such as breast, skin, and prostate may remain dormant for long periods of time. In the…”
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Resveratrol: Challenges in Translation to the Clinic — A Critical Discussion by SUBRAMANIAN, Lalita, YOUSSEF, Sherry, BHATTACHARYA, Saswati, KENEALEY, Jason, POLANS, Arthur S, VAN GINKEL, Paul R

“…Low cancer survival rates and the serious side effects often associated with current chemotherapeutics highlight the need for new and effective nontoxic…”
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SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction by Dhillon, Rashpal S., Qin, Yiming (Amy), Ginkel, Paul R., Fu, Vivian X., Vann, James M., Lawton, Alexis J., Green, Cara L., Manchado‐Gobatto, Fúlvia B., Gobatto, Claudio A., Lamming, Dudley W., Prolla, Tomas A., Denu, John M.

“…Mitochondrial NAD+‐dependent protein deacetylase Sirtuin3 (SIRT3) has been proposed to mediate calorie restriction (CR)‐dependent metabolic regulation and…”
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Aerobic training associated with an active lifestyle exerts a protective effect against oxidative damage in hypothalamus and liver: The involvement of energy metabolism by Scariot, Pedro P.M., Manchado-Gobatto, Fúlvia B., Van Ginkel, Paul R., Prolla, Tomas A., Gobatto, Claudio A.

“…•A large cage stimulates a physically active lifestyle in mice.•Trained mice kept in a large cage exhibited high OXR1 in hypothalamus and liver.•A more active…”
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Resveratrol Metabolites Do Not Elicit Early Pro-apoptotic Mechanisms in Neuroblastoma Cells by Kenealey, Jason D, Subramanian, Lalita, Van Ginkel, Paul R, Darjatmoko, Soesiawati, Lindstrom, Mary J, Somoza, Veronika, Ghosh, Sunil K, Song, Zhenlei, Hsung, Richard P, Kwon, Glen S, Eliceiri, Kevin W, Albert, Daniel M, Polans, Arthur S

“…Resveratrol, a nontoxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly…”
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Resveratrol Inhibits Uveal Melanoma Tumor Growth via Early Mitochondrial Dysfunction by van Ginkel, Paul R, Darjatmoko, Soesiawati R, Sareen, Dhruv, Subramanian, Lalita, Bhattacharya, Saswati, Lindstrom, Mary J, Albert, Daniel M, Polans, Arthur S

“…To test the efficacy of resveratrol, a nontoxic plant product, in the treatment of uveal melanoma. The effect of oral administration and peritumor injection of…”
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Ca2+ Binding to EF Hands 1 and 3 Is Essential for the Interaction of Apoptosis-Linked Gene-2 with Alix/AIP1 in Ocular Melanoma by Subramanian, Lalita, Crabb, John W., Cox, Jos, Durussel, Isabelle, Walker, Teresa M., van Ginkel, Paul R., Bhattacharya, Saswati, Dellaria, Julia M., Palczewski, Krzysztof, Polans, Arthur S.

“…Apoptosis-linked gene-2 (ALG-2) encodes a 22 kDa Ca2+-binding protein of the penta EF-hand family that is required for programmed cell death in response to…”
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1 alpha-Hydroxyvitamin D2 inhibits growth of human neuroblastoma by van Ginkel, Paul R, Yang, William, Marcet, Marcus M, Chow, Clement C, Kulkarni, Amol D, Darjatmoko, Soesiawati, Lindstrom, Mary J, Lokken, Janice, Bhattacharya, Saswati, Albert, Daniel M

“…Neuroblastoma is the most common extracranial solid tumor in childhood. The poor outcomes of patients with high-risk neuroblastoma have encouraged the search…”
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E2F-mediated Growth Regulation Requires Transcription Factor Cooperation by van Ginkel, Paul R., Hsiao, Kuang-Ming, Schjerven, Hilde, Farnham, Peggy J.

“…Previous studies have indicated that the presence of an E2F site is not sufficient for G1/S phase transcriptional regulation. For example, the E2F sites in the…”
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Sirtuin 3‐ and Diet‐Mediated Regulation of Mitochondrial Function During Aging by Dhillon, Rashpal S., van Ginkel, Paul R., Fu, Vivian, Prolla, Tomas A., Denu, John M.

“…Abstract only Aging is a multifactorial process that results in the gradual damage of a number of cellular systems. Specifically, the decline of mitochondrial…”
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Resveratrol Targets AKT and p53 in Glioblastoma and Glioblastoma Stem-like Cells to Suppress Growth and Infiltration by Clark, Paul A., Bhattacharya, Saswati, Elmayan, Ardem, Darjatmoko, Soesiawati R., Thuro, Bradley A., Yan, Michael B., van Ginkel, Paul R., Polans, Arthur S., Kuo, John S.

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Expression of angiogenic factors Cyr61 and tissue factor in uveal melanoma by Walker, Teresa M, Van Ginkel, Paul R, Gee, Ricardo L, Ahmadi, Hoda, Subramanian, Lalita, Ksander, Bruce R, Meisner, Lorraine F, Albert, Daniel M, Polans, Arthur S

“…To study the expression of angiogenic factors Cyr61 and tissue factor (TF) in uveal melanoma and its correlation with blood vessel density. Suppression…”
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