Search Results - "VAN GENT, Michiel"

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity by Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.

“…Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an…”
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High-throughput RNA sequencing of paraformaldehyde-fixed single cells by Phan, Hoang Van, van Gent, Michiel, Drayman, Nir, Basu, Anindita, Gack, Michaela U., Tay, Savaş

“…Single-cell transcriptomic studies that require intracellular protein staining, rare cell sorting, or inactivation of infectious pathogens are severely…”
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EBV MicroRNA BART16 Suppresses Type I IFN Signaling by Hooykaas, Marjolein J G, van Gent, Michiel, Soppe, Jasper A, Kruse, Elisabeth, Boer, Ingrid G J, van Leenen, Dik, Groot Koerkamp, Marian J A, Holstege, Frank C P, Ressing, Maaike E, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response…”
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Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity by Chiang, Jessica J., Sparrer, Konstantin M. J., van Gent, Michiel, Lässig, Charlotte, Huang, Teng, Osterrieder, Nikolaus, Hopfner, Karl-Peter, Gack, Michaela U.

“…The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to have a role in the antiviral response to DNA viruses,…”
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Viral Anti-CRISPR Tactics: No Success without Sacrifice by van Gent, Michiel, Gack, Michaela U.

“…Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018)…”
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Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV by van Gent, Michiel, Reich, Adrian, Velu, Sadanandan E, Gack, Michaela U

“…The oncogenic human herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are the causative agents of multiple…”
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A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase by Buchan, Kyle D, Prajsnar, Tomasz K, Ogryzko, Nikolay V, de Jong, Nienke W M, van Gent, Michiel, Kolata, Julia, Foster, Simon J, van Strijp, Jos A G, Renshaw, Stephen A

“…The neutrophil enzyme myeloperoxidase (MPO) is a major enzyme made by neutrophils to generate antimicrobial and immunomodulatory compounds, notably…”
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Neurovirulence of Usutu virus in human fetal organotypic brain slice cultures partially resembles Zika and West Nile virus by Marshall, Eleanor M., Rashidi, Ahmad S., van Gent, Michiel, Rockx, Barry, Verjans, Georges M. G. M.

“…Usutu (USUV), West Nile (WNV), and Zika virus (ZIKV) are neurotropic arthropod-borne viruses (arboviruses) that cause severe neurological disease in humans…”
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The herpesvirus accessory protein γ134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I by Liu, Xing, Ma, Yijie, Voss, Kathleen, van Gent, Michiel, Chan, Ying Kai, Gack, Michaela U, Gale, Jr, Michael, He, Bin

“…RIG-I and MDA5 are cytoplasmic RNA sensors that mediate cell intrinsic immunity against viral pathogens. While it has been well-established that RIG-I and MDA5…”
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Herpes simplex virus infection induces necroptosis of neurons and astrocytes in human fetal organotypic brain slice cultures by Rashidi, Ahmad S, Tran, Diana N, Peelen, Caithlin R, van Gent, Michiel, Ouwendijk, Werner J D, Verjans, Georges M G M

“…Herpes simplex virus (HSV) encephalitis (HSE) is a serious and potentially life-threatening disease, affecting both adults and newborns. Progress in…”
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Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling by van Gent, Michiel, Braem, Steven G E, de Jong, Annemieke, Delagic, Nezira, Peeters, Janneke G C, Boer, Ingrid G J, Moynagh, Paul N, Kremmer, Elisabeth, Wiertz, Emmanuel J, Ovaa, Huib, Griffin, Bryan D, Ressing, Maaike E

“…Viral infection triggers an early host response through activation of pattern recognition receptors, including Toll-like receptors (TLR). TLR signaling…”
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Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia by van Gent, Michiel, Ouwendijk, Werner J D, Campbell, Victoria L, Laing, Kerry J, Verjans, Georges M G M, Koelle, David M

“…Trigeminal ganglia (TG) neurons are an important site of lifelong latent varicella-zoster virus (VZV) infection. Although VZV-specific T-cells are considered…”
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Topology and Membrane Anchoring of the Coronavirus Replication Complex: Not All Hydrophobic Domains of nsp3 and nsp6 Are Membrane Spanning by OOSTRA, Monique, HAGEMEIJER, Marne C, VAN GENT, Michiel, BEKKER, Cornelis P. J, TE LINTELO, Eddie G, ROTTIER, Peter J. M, DE HAAN, Cornelis A. M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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EBV lytic-phase protein BGLF5 contributes to TLR9 downregulation during productive infection by van Gent, Michiel, Griffin, Bryan D, Berkhoff, Eufemia G, van Leeuwen, Daphne, Boer, Ingrid G J, Buisson, Marlyse, Hartgers, Franca C, Burmeister, Wim P, Wiertz, Emmanuel J, Ressing, Maaike E

“…Viruses use a wide range of strategies to modulate the host immune response. The human gammaherpesvirus EBV, causative agent of infectious mononucleosis and…”
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Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity by Full, Florian, van Gent, Michiel, Sparrer, Konstantin M. J., Chiang, Cindy, Zurenski, Matthew A., Scherer, Myriam, Brockmeyer, Norbert H., Heinzerling, Lucie, Stürzl, Michael, Korn, Klaus, Stamminger, Thomas, Ensser, Armin, Gack, Michaela U.

“…Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we…”
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Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin by Tromp, Angelino T., Van Gent, Michiel, Abrial, Pauline, Martin, Amandine, Jansen, Joris P., De Haas, Carla J. C., Van Kessel, Kok P. M., Bardoel, Bart W., Kruse, Elisabeth, Bourdonnay, Emilie, Boettcher, Michael, McManus, Michael T., Day, Christopher J., Jennings, Michael P., Lina, Gérard, Vandenesch, François, Van Strijp, Jos A. G., Lebbink, Robert Jan, Haas, Pieter-Jan A., Henry, Thomas, Spaan, András N.

“…The staphylococcal bi-component leukocidins Panton–Valentine leukocidin (PVL) and γ-haemolysin CB (HlgCB) target human phagocytes. Binding of the toxins’…”
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Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity by Tromp, Angelino T, Van Gent, Michiel, Jansen, Joris P, Scheepmaker, Lisette M, Velthuizen, Anneroos, De Haas, Carla J C, Van Kessel, Kok P M, Bardoel, Bart W, Boettcher, Michael, McManus, Michael T, Van Strijp, Jos A G, Lebbink, Robert Jan, Haas, Pieter-Jan A, Spaan, András N

“…Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of…”
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Publisher Correction: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin by Tromp, Angelino T., Van Gent, Michiel, Abrial, Pauline, Martin, Amandine, Jansen, Joris P., De Haas, Carla J. C., Van Kessel, Kok P. M., Bardoel, Bart W., Kruse, Elisabeth, Bourdonnay, Emilie, Boettcher, Michael, McManus, Michael T., Day, Christopher J., Jennings, Michael P., Lina, Gérard, Vandenesch, François, Van Strijp, Jos A. G., Lebbink, Robert Jan, Haas, Pieter-Jan A., Henry, Thomas, Spaan, András N.

“…In the version of this Article originally published, the name of author Robert Jan Lebbink was coded wrongly, resulting in it being incorrect when exported to…”
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TRIM Proteins and Their Roles in Antiviral Host Defenses by van Gent, Michiel, Sparrer, Konstantin M.J, Gack, Michaela U

“…Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a multitude of cellular processes. Studies in recent years have…”
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The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity by van Gent, Michiel, Chiang, Jessica J, Muppala, Santoshi, Chiang, Cindy, Azab, Walid, Kattenhorn, Lisa, Knipe, David M, Osterrieder, Nikolaus, Gack, Michaela U

“…Recent studies have demonstrated that the signaling activity of the cytosolic pathogen sensor retinoic acid-inducible gene-I (RIG-I) is modulated by a variety…”
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