Search Results - "VAN DUIN, Mark"

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia by Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud

“…Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic…”
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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape by de Jong, Madelon M. E., Kellermayer, Zoltán, Papazian, Natalie, Tahri, Sabrin, Hofste op Bruinink, Davine, Hoogenboezem, Remco, Sanders, Mathijs A., van de Woestijne, Pieter C., Bos, P. Koen, Khandanpour, Cyrus, Vermeulen, Jessica, Moreau, Philippe, van Duin, Mark, Broijl, Annemiek, Sonneveld, Pieter, Cupedo, Tom

“…Progression and persistence of malignancies are influenced by the local tumor microenvironment, and future eradication of currently incurable tumors will, in…”
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CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma by Nijhof, Inger S., Casneuf, Tineke, van Velzen, Jeroen, van Kessel, Berris, Axel, Amy E., Syed, Khaja, Groen, Richard W.J., van Duin, Mark, Sonneveld, Pieter, Minnema, Monique C., Zweegman, Sonja, Chiu, Christopher, Bloem, Andries C., Mutis, Tuna, Lokhorst, Henk M., Sasser, A.Kate, van de Donk, Niels W.C.J.

“…The anti-CD38 monoclonal antibody daratumumab is well tolerated and has high single agent activity in heavily pretreated relapsed and refractory multiple…”
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Editorial: Risk factors in multiple myeloma identified before and during treatment: are we ready to personalize treatment? by D’Agostino, Mattia, Terragna, Carolina, van Duin, Mark

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Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors by Tornatore, Laura, Sandomenico, Annamaria, Raimondo, Domenico, Low, Caroline, Rocci, Alberto, Tralau-Stewart, Cathy, Capece, Daria, D’Andrea, Daniel, Bua, Marco, Boyle, Eileen, van Duin, Mark, Zoppoli, Pietro, Jaxa-Chamiec, Albert, Thotakura, Anil K., Dyson, Julian, Walker, Brian A., Leonardi, Antonio, Chambery, Angela, Driessen, Christoph, Sonneveld, Pieter, Morgan, Gareth, Palumbo, Antonio, Tramontano, Anna, Rahemtulla, Amin, Ruvo, Menotti, Franzoso, Guido

“…Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell…”
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Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients by Broyl, Annemiek, Hose, Dirk, Lokhorst, Henk, de Knegt, Yvonne, Peeters, Justine, Jauch, Anna, Bertsch, Uta, Buijs, Arjan, Stevens-Kroef, Marian, Beverloo, H. Berna, Vellenga, Edo, Zweegman, Sonja, Kersten, Marie-Josée, van der Holt, Bronno, el Jarari, Laila, Mulligan, George, Goldschmidt, Hartmut, van Duin, Mark, Sonneveld, Pieter

“…To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed…”
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VS38c and CD38-Multiepitope Antibodies Provide Highly Comparable Minimal Residual Disease Data in Patients With Multiple Myeloma by Broijl, Annemiek, de Jong, Augustinus C M, van Duin, Mark, Sonneveld, Pieter, Kühnau, Jesper, van der Velden, Vincent H J

“…Abstract Objectives To compare flow cytometric minimal residual disease (MRD) data obtained using the EuroFlow approach, including the CD38-multiepitope (ME)…”
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MCL1 gene co‐expression module stratifies multiple myeloma and predicts response to proteasome inhibitor‐based therapy by Samo, Ayaz Ali, Li, Jiuyi, Zhou, Min, Sun, Yingyu, Yang, Yuan, Zhang, Yunqiu, Li, Jing, van Duin, Mark, Lu, Xuzhang, Fan, Xiaolong

“…Multiple myeloma (MM) is the second most common hematologic cancer, characterized by abnormal accumulation of plasma cells in the bone marrow. The extensive…”
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Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial by Broyl, Annemiek, Dr, Corthals, Sophie L, MSc, Jongen, Joost LM, MD, van der Holt, Bronno, PhD, Kuiper, Rowan, BSc, de Knegt, Yvonne, BSc, van Duin, Mark, PhD, el Jarari, Laila, MSc, Bertsch, Uta, MD, Lokhorst, Henk M, Prof, Durie, Brian G, MD, Goldschmidt, Hartmut, Prof, Sonneveld, Pieter, Prof

“…Summary Background Bortezomib-induced peripheral neuropathy is a dose-limiting toxicity in patients with multiple myeloma, often requiring adjustment of…”
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The myeloma stem cell concept, revisited: from phenomenology to operational terms by Johnsen, Hans Erik, Bøgsted, Martin, Schmitz, Alexander, Bødker, Julie Støve, El-Galaly, Tarec Christoffer, Johansen, Preben, Valent, Peter, Zojer, Niklas, Van Valckenborgh, Els, Vanderkerken, Karin, van Duin, Mark, Sonneveld, Pieter, Perez-Andres, Martin, Orfao, Alberto, Dybkær, Karen

“…The concept of the myeloma stem cell may have important therapeutic implications, yet its demonstration has been hampered by a lack of consistency in terms and…”
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V-Domain Ig Suppressor of T Cell Activation (VISTA) Expression Is an Independent Prognostic Factor in Multiple Myeloma by Mutsaers, Pim, Balcioglu, Hayri E., Kuiper, Rowan, Hammerl, Dora, Wijers, Rebecca, van Duin, Mark, van der Holt, Bronno, Broijl, Annemiek, Gregory, Walter, Zweegman, Sonja, Sonneveld, Pieter, Debets, Reno

“…Multiple myeloma (MM) is characterized by loss of anti-tumor T cell immunity. Despite moderate success of treatment with anti-PD1 antibodies, effective…”
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Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma by Hofman, Isabel J F, Patchett, Stephanie, van Duin, Mark, Geerdens, Ellen, Verbeeck, Jelle, Michaux, Lucienne, Delforge, Michel, Sonneveld, Pieter, Johnson, Arlen W, De Keersmaecker, Kim

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Treatment emergent peripheral neuropathy in the CASSIOPEIA trial by Fokkema, Cathelijne, Moreau, Phillipe, Van der Holt, Bronno, Lambert, Jérôme, Van Duin, Mark, Wester, Ruth, Jongen, Joost L M, Van Doorn, Pieter A, Godet, Sophie, Jie, Kon Siong, Fitoussi, Olivier, Delforge, Michel, Keita-Manta, Awa, Luycx, Odile, Cupedo, Tom, Van de Donk, Niels W C J, Zweegman, Sonja, Vermeulen, Jessica T, Sonneveld, Pieter, Broijl, Annemiek

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Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients by Wu, S Peter, Pfeiffer, Ruth M, Ahn, Inhye E, Mailankody, Sham, Sonneveld, Pieter, van Duin, Mark, Munshi, Nikhil C, Walker, Brian A, Morgan, Gareth, Landgren, Ola

“…The poor prognosis of multiple myeloma with t(4;14) is driven by the fusion of genes encoding multiple myeloma SET domain (MMSET) and immunoglobulin heavy…”
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Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes by Went, Molly, Kinnersley, Ben, Sud, Amit, Johnson, David C, Weinhold, Niels, Försti, Asta, van Duin, Mark, Orlando, Giulia, Mitchell, Jonathan S, Kuiper, Rowan, Walker, Brian A, Gregory, Walter M, Hoffmann, Per, Jackson, Graham H, Nöthen, Markus M, da Silva Filho, Miguel Inacio, Thomsen, Hauke, Broyl, Annemiek, Davies, Faith E, Thorsteinsdottir, Unnur, Hansson, Markus, Kaiser, Martin, Sonneveld, Pieter, Goldschmidt, Hartmut, Stefansson, Kari, Hemminki, Kari, Nilsson, Björn, Morgan, Gareth J, Houlston, Richard S

“…While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these…”
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P804: PLASMA CELL LEUKEMIA‐LIKE TRANSCRIPTOME OF BONE MARROW PLASMA CELLS AND CIRCULATING TUMOR CELL LEVELS IN PERIPHERAL BLOOD COMPLEMENTARILY DEFINE HIGH‐RISK IN NEWLY DIAGNOSED MULTIPLE MYELOMA by D’agostino, Mattia, Bruinink, Davine Hofste Op, Duin, Mark, Rota‐Scalabrini, Delia, Bertamini, Luca, Kuiper, Rowan, Belotti, Angelo, Marasco, Vincenzo, Oliva, Stefania, Rivolti, Elena, Rogers, Jennifer, Mina, Roberto, Grasso, Mariella, Ledda, Antonio, Offidani, Massimo, Galli, Monica, Cavo, Michele, Broijl, Annemiek, Musto, Pellegrino, Bruno, Benedetto, Boccadoro, Mario, Sonneveld, Pieter, Gay, Francesca

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Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors by Tornatore, Laura, Sandomenico, Annamaria, Raimondo, Domenico, Low, Caroline, Rocci, Alberto, Tralau-Stewart, Cathy, Capece, Daria, D’Andrea, Daniel, Bua, Marco, Boyle, Eileen, van Duin, Mark, Zoppoli, Pietro, Jaxa-Chamiec, Albert, Thotakura, Anil K., Dyson, Julian, Walker, Brian A., Leonardi, Antonio, Chambery, Angela, Driessen, Christoph, Sonneveld, Pieter, Morgan, Gareth, Palumbo, Antonio, Tramontano, Anna, Rahemtulla, Amin, Ruvo, Menotti, Franzoso, Guido

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Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma by Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt-Marie, Weinhold, Niels, Kimber, Scott, van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C., Li, Ni, Orlando, Giulia, Law, Philip J., Ali, Mina, Chen, Bowang, Mitchell, Jonathan S., Gudbjartsson, Daniel F., Kuiper, Rowan, Stephens, Owen W., Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R, Einsele, Hermann, Gregory, Walter A., Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H., Jöckel, Karl-Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y., Mellqvist, Ulf-Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Nickel, Jolanta, Nöthen, Markus M., Rafnar, Thorunn, Ross, Fiona M., da Silva Filho, Miguel Inacio, Thomsen, Hauke, Turesson, Ingemar, Vangsted, Annette, Andersen, Niels Frost, Waage, Anders, Walker, Brian A., Wihlborg, Anna-Karin, Broyl, Annemiek, Davies, Faith E., Thorsteinsdottir, Unnur, Langer, Christian, Hansson, Markus, Goldschmidt, Hartmut, Kaiser, Martin, Sonneveld, Pieter, Stefansson, Kari, Morgan, Gareth J., Hemminki, Kari, Nilsson, Björn, Houlston, Richard S.

“…The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly…”
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Cancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy by VAN DUIN, Mark, BROYL, Annemiek, SAHOTA, Surinder S, SONNEVELD, Pieter, DE KNEGT, Yvonne, GOLDSCHMIDT, Hartmut, RICHARDSON, Paul G, HOP, Wim C. J, VAN DER HOLT, Bronno, JOSEPH-PIETRAS, Debora, MULLIGAN, George, NEUWIRTH, Rachel

“…In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not…”
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The impact of comorbidities on costs, utilities and health-related quality of life among HIV patients in a clinical setting in Bogotá by Van Duin, Mark Jm, Conde, Rafael, Wijnen, Ben, Evers, Silvia Maa, Gonzalez-Rodriguez, Javier L, Govers, Mark Jg, Hiligsmann, Mickaël

“…This study aimed to assess the impact of comorbidities (CMs) on costs, utilities and health-related quality of life (HRQOL) among HIV patients in Colombia. A…”
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