Search Results - "VAN DER VOORT, Robbert"

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention by Norde, Wieger J., Hobo, Willemijn, van der Voort, Robbert, Dolstra, Harry

“…The adaptive immune system can be a potent defense mechanism against cancer; however, it is often hampered by immune suppressive mechanisms in the tumor…”
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CXCR4, but not CXCR3, drives CD8+ T‐cell entry into and migration through the murine bone marrow by Goedhart, Marieke, Gessel, Stephanie, der Voort, Robbert, Slot, Edith, Lucas, Beth, Gielen, Ellis, Hoogenboezem, Mark, Rademakers, Timo, Geerman, Sulima, Buul, Jaap D., Huveneers, Stephan, Dolstra, Harry, Anderson, Graham, Voermans, Carlijn, Nolte, Martijn A.

“…The BM serves as a blood‐forming organ, but also supports the maintenance and immune surveillance function of many T cells. Yet, in contrast to other organs,…”
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Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles by Paus, Carmen, van der Voort, Robbert, Cambi, Alessandra

“…The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable…”
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Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rgnull Mice by Cany, Jeannette, van der Waart, Anniek B., Tordoir, Marleen, Franssen, Gerben M., Hangalapura, Basav N., de Vries, Jolanda, Boerman, Otto, Schaap, Nicolaas, van der Voort, Robbert, Spanholtz, Jan, Dolstra, Harry

“…Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for patients with acute myeloid leukemia. Recently, we…”
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Expression of c-Met and Heparan-Sulfate Proteoglycan Forms of CD44 in Colorectal Cancer by Wielenga, Vera J.M., van der Voort, Robbert, Taher, Taher E.I., Smit, Lia, Beuling, Esther A., van Krimpen, Cees, Spaargaren, Marcel, Pals, Steven T.

“…In colorectal cancer patients, prognosis is not determined by the primary tumor but by the formation of distant metastases. Molecules that have been implicated…”
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Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice by Cany, Jeannette, van der Waart, Anniek B, Tordoir, Marleen, Franssen, Gerben M, Hangalapura, Basav N, de Vries, Jolanda, Boerman, Otto, Schaap, Nicolaas, van der Voort, Robbert, Spanholtz, Jan, Dolstra, Harry

“…Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for patients with acute myeloid leukemia. Recently, we…”
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Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway by van der Voort, R, Taher, T E, Keehnen, R M, Smit, L, Groenink, M, Pals, S T

“…T cell-dependent humoral immune responses are initiated by the activation of naive B cells in the T cell areas of the secondary lymphoid tissues. This primary…”
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In situ tumor ablation creates an antigen source for the generation of antitumor immunity by BROK, Martijn H. M. G. M. Den, SUTMULLER, Roger P. M, VAN DER VOORT, Robbert, BENNINK, Erik J, FIGDOR, Carl G, RUERS, Theo J. M, ADEMA, Gosse J

“…Tumor-destructing techniques, like radiofrequency ablation (RFA), allow eradication of large tumors. Potentially, in situ tumor destruction also can provide…”
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Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid by van Lieshout, Antoine W T, van der Voort, Robbert, le Blanc, Linda M P, Roelofs, Mieke F, Schreurs, B Willem, van Riel, Piet L C M, Adema, Gosse J, Radstake, Timothy R D J

“…The T cell attracting chemokine CCL18 is produced by antigen presenting cells and a role for CCL18 has been suggested in the pathogenesis of a variety of…”
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Decreased levels of circulating IL17-producing CD161+CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation by van der Waart, Anniek B, van der Velden, Walter J F M, van Halteren, Astrid G S, Leenders, Marij J L G, Feuth, Ton, Blijlevens, Nicole M A, van der Voort, Robbert, Dolstra, Harry

“…The C-type lectin-like receptor CD161 is a well-established marker for human IL17-producing T cells, which have been implicated to contribute to the…”
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An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells by Voort, Robbert, Verweij, Viviènne, Witte, Theo M., Lasonder, Edwin, Adema, Gosse J., Dolstra, Harry

“…A secreted isoform of the chemokine CXCL16 contributes to the interaction between dendritic cells and CXCR6+ lymphocytes. DC are professional APCs that…”
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Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1–reactive cytotoxic T cells by Norde, Wieger J., Overes, Ingrid M., Maas, Frans, Fredrix, Hanny, Vos, Johanna C.M., Kester, Michel G.D., van der Voort, Robbert, Jedema, Inge, Falkenburg, J. H. Frederik, Schattenberg, Anton V., de Witte, Theo M., Dolstra, Harry

“…CD8+ T cells recognizing minor histocompatibility antigens (MiHAs) on leukemic stem and progenitor cells play a pivotal role in effective graft-versus-leukemia…”
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Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met by van der Voort, R, Taher, T E, Wielenga, V J, Spaargaren, M, Prevo, R, Smit, L, David, G, Hartmann, G, Gherardi, E, Pals, S T

“…CD44 has been implicated in tumor progression and metastasis, but the mechanism(s) involved is as yet poorly understood. Recent studies have shown that CD44…”
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Analysis of dendritic cell trafficking using EGFP-transgenic mice by Eggert, Andreas A.O., van der Voort, Robbert, Torensma, Ruurd, Moulin, Veronique, Boerman, Otto C., Oyen, Wim J.G., Punt, C.J.A., Diepstra, Heleen, de Boer, Annemiek J., Figdor, Carl G., Adema, Gosse J.

“…Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response,…”
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Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions by Van der Voort, Robbert, Kramer, Matthijs, Lindhout, Ernst, Torensma, Ruurd, Eleveld, Dagmar, Van Lieshout, Antoine W. T., Looman, Maaike, Ruers, Theo, Radstake, Timothy R. D. J., Figdor, Carl G., Adema, Gosse J.

“…CC chemokine ligand 18/dendritic cell‐chemokine 1 (CCL18/DC‐CK1) is a CC chemokine, preferentially expressed by DC, which acts as a chemoattractant for naive T…”
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Challenges in the Pathophysiology, Diagnosis, and Management of Intestinal Fibrosis in Inflammatory Bowel Disease by D’Haens, Geert, Rieder, Florian, Feagan, Brian G., Higgins, Peter D.R., Panés, Julian, Maaser, Christian, Rogler, Gerhard, Löwenberg, Mark, van der Voort, Robbert, Pinzani, Massimo, Peyrin-Biroulet, Laurent, Danese, Silvio, Allocca, Mariangela, De Hertogh, Gert, Denton, Chris, Distler, Jörg, McCarrier, Kelly, McGovern, Dermot, Radstake, Tim, Serrano, Daniel, Stoker, Jaap

“…Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) that is usually the consequence of chronic inflammation. Although the…”
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siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen–specific CD8+ T cells by Hobo, Willemijn, Maas, Frans, Adisty, Niken, de Witte, Theo, Schaap, Nicolaas, van der Voort, Robbert, Dolstra, Harry

“…Tumor relapse after human leukocyte antigen–matched allogeneic stem cell transplantation (SCT) remains a serious problem, despite the long-term presence of…”
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Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation by Hobo, Willemijn, Novobrantseva, Tatiana I., Fredrix, Hanny, Wong, Jamie, Milstein, Stuart, Epstein-Barash, Hila, Liu, Ju, Schaap, Nicolaas, van der Voort, Robbert, Dolstra, Harry

“…Dendritic cell (DC)-based vaccination boosting antigen-specific immunity is being explored for the treatment of cancer and chronic viral infections. Although…”
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Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy by van der Waart, Anniek B., Noortje van de Weem, M.P., Maas, Frans, Kramer, Cynthia S.M., Michel Kester, G.D., Frederik Falkenburg, J.H., Schaap, Nicolaas, Jansen, Joop H., van der Voort, Robbert, Gattinoni, Luca, Hobo, Willemijn, Dolstra, Harry

“…Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell–like T cells with the ability to self-renew and differentiate…”
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Interleukin-12 has no Effect on Vascular Density, Perfusion, Hypoxia and Proliferation of an Implanted Human Squamous Cell Carcinoma Xenograft Tumour Despite Up-regulation of ICAM-1 by VAN HERPEN, Carla M. L, BUSSINK, Johan, VAN DER KOGEL, Albert J, PEETERS, Wenny J. M, VAN DER VOORT, Robbert, VAN SCHIJNDEL, Anita, DE WILDE, Peter C. M, ADEMA, Gosse J, DE MULDER, Pieter H. M

“…Background: Interleukin-12 is an anti-angiogenic and antitumor agent in many transplanted murine tumour models. In a previous clinical study in head and neck…”
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