Search Results - "VAN DEN ELSEN, PJ"

Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men by Holling, Tjadine M, Schooten, Erik, van Den Elsen, Peter J

“…The main function of major histocompatibility complex (MHC) class II molecules is to present processed antigens, which are derived primarily from exogenous…”
Get full text

Transcriptional regulation of antigen presentation by van den Elsen, Peter J, Holling, Tjadine M, Kuipers, Hedwich F, van der Stoep, Nienke

“…MHC class I and class II molecules play essential roles in the adaptive immune response by virtue of their ability to present peptides to T lymphocytes. Given…”
Get full text

Activated Human T Cells Accomplish MHC Class II Expression Through T Cell-Specific Occupation of Class II Transactivator Promoter III by Holling, Tjadine M, van der Stoep, Nienke, Quinten, Edwin, van den Elsen, Peter J

“…Activated human T cells express HLA-DR, HLA-DQ, and HLA-DP on their surface, but the regulation and functioning of MHC class II molecules in T lymphocytes are…”
Get full text

Regulation of MHC class II expression in human T-cell malignancies by Holling, Tjadine M., Schooten, Erik, Langerak, Anton W., van den Elsen, Peter J.

“…Expression of major histocompatibility complex (MHC) class II molecules in human activated T cells is under normal circumstances regulated exclusively by the…”
Get full text

Gain of chromosome 6 status does not influence HLA‐expression in uveal melanoma by VAN PELT, S, VAN ESSEN, TH, BRONKHORST, IHG, VERSLUIS, M, LUYTEN, GPM, VAN HALL, T, VAN DEN ELSEN, PJ, VAN VELDEN, PA, JAGER, MJ

“…Purpose Chromosomal aberrations and the inflammatory phenotype have been identified as predictive factors for survival of uveal melanoma (UM). The mechanism by…”
Get full text

Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells by Ossendorp, Ferry, Fu, Nathalie, Camps, Marcel, Granucci, Francesca, Gobin, Sam J P, van den Elsen, Peter J, Schuurhuis, Danita, Adema, Gosse J, Lipford, Grayson B, Chiba, Tomoki, Sijts, Alice, Kloetzel, Peter-M, Ricciardi-Castagnoli, Paola, Melief, Cornelis J M

“…Activation of dendritic cells (DC) by Th-dependent (CD40) or -independent (LPS, CpG, or immune complexes) agonistic stimuli strongly enhances the expression of…”
Get full text

The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation by Gobin, S J, van Zutphen, M, Westerheide, S D, Boss, J M, van den Elsen, P J

“…The promoter regions of MHC class I and beta(2)-microglobulin (beta(2)m) genes possess a regulatory module consisting of S, X, and Y boxes, which is shared by…”
Get full text

Statins Affect Cell-Surface Expression of Major Histocompatibility Complex Class II Molecules by Disrupting Cholesterol-Containing Microdomains by Kuipers, Hedwich F., Biesta, Paula J., Groothuis, Tom A., Neefjes, Jacques J., Mommaas, A. Mieke, van den Elsen, Peter J.

“…Statins, the main therapy for hypercholesterolemia, are currently considered as possible immunomodulatory agents. Statins inhibit the production of…”
Get full text

Structural and functional differences between the promoters of independently expressed killer cell Ig‐like receptors by van Bergen, Jeroen, Stewart, C. Andrew, van den Elsen, Peter J., Trowsdale, John

“…Killer Ig‐like receptors (KIR) are important for the recognition and elimination of diseased cells by human NK cells. Myeloid leukemia patients given a…”
Get full text

FUNCTIONAL ANALYSIS OF LINKER-SCAN MUTANTS SPANNING THE −376, −308, −244, AND −238 POLYMORPHIC SITES OF THE TNF-α PROMOTER by Bayley, Jean-Pierre, de Rooij, Henny, van Den Elsen, Peter J., Huizinga, Tom W.J., Verweij, Cornelis L.

“…Tumor necrosis factor alpha (TNF-α) promoter polymorphisms have been linked to a large number of diseases but studies examining the possible direct functional…”
Get full text

Loss of interferon-γ inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as well as epigenetic regulation by Meissner, M., Whiteside, T.L., Van Kuik-Romein, P., Valesky, E.M., Van Den Elsen, P.J., Kaufmann, R., Seliger, B.

“…Summary Background  Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair the cellular immune response and promote tumour…”
Get full text

Site α Is Crucial for Two Routes of IFNγ-Induced MHC Class I Transactivation: The ISRE-Mediated Route and a Novel Pathway Involving CIITA by Gobin, Sam J.P, Peijnenburg, Ad, Keijsers, Vivian, van den Elsen, Peter J

“…The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this…”
Get full text

E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII) by van der Stoep, Nienke, Quinten, Edwin, Rezende, Marisa Marcondes, van den Elsen, Peter J.

“…In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation…”
Get full text

Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5'-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes by van der Stoep, Nienke, Quinten, Edwin, van den Elsen, Peter J

“…The class II trans-activator (CIITA), which acts as a master regulator for expression of MHC class II genes, is expressed constitutively in mature B cells…”
Get full text

Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G by Gobin, Sam J.P, van den Elsen, Peter J

“…The restricted tissue expression of the MHC class Ib molecules HLA-E, HLA-F, and HLA-G has suggested specialized functions and tight transcriptional control of…”
Get full text

HLA-G transactivation by cAMP-response element-binding protein (CREB). An alternative transactivation pathway to the conserved major histocompatibility complex (MHC) class I regulatory routes by Gobin, Sam J P, Biesta, Paula, de Steenwinkel, Jurriaan E M, Datema, Gert, van den Elsen, Peter J

“…The expression of HLA-G in extravillous cytotrophoblast cells coincides with a general lack of classical major histocompatibility complex (MHC) class I…”
Get full text

Lack of ifn‐γ‐mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines by van der Stoep, Nienke, Biesta, Paula, Quinten, Edwin, van den Elsen, Peter J.

“…Downregulation of major histocompatibility complex (MHC) molecules by tumor cells impairs cellular immune recognition and contributes to inefficient…”
Get full text

The role of enhancer A in the locus-specific transactivation of classical and nonclassical HLA class I genes by nuclear factor kappa B by Gobin, S J, Keijsers, V, van Zutphen, M, van den Elsen, P J

“…HLA class I expression is tightly controlled at the transcriptional level by several conserved regulatory elements in the proximal promoter region. In this…”
Get full text

CX3CL1 and CX3CR1 Expression in Human Brain Tissue: Noninflammatory Control versus Multiple Sclerosis by HULSHOF, SANDRA, VAN HAASTERT, ELISE S, KUIPERS, HEDWICH F, VAN DEN ELSEN, PETER J, DE GROOT, CORLINE J, VAN DER VALK, PAUL, RAVID, RIVKA, BIBER, KNUT

“…An important role for CX3CL1 in neuroinflammation and neurodegeneration has been suggested in recent publications. In this study, we compared the expression of…”
Get full text

Transactivation of Classical and Nonclassical HLA Class I Genes Through the IFN-Stimulated Response Element by Gobin, Sam J. P, Zutphen, Marlijn van, Woltman, Andrea M, Elsen, Peter J. van den

“…The IFN-stimulated response element (ISRE) is an important conserved cis-acting regulatory element in the promoter of MHC class I genes, but displays…”
Get full text