Search Results - "VAN DE GRAAF, Stan F. J"

N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection by Appelman, Monique D, Chakraborty, Anindita, Protzer, Ulrike, McKeating, Jane A, van de Graaf, Stan F J

“…The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in…”
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Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP by Donkers, Joanne M., Zehnder, Benno, van Westen, Gerard J. P., Kwakkenbos, Mark J., IJzerman, Adriaan P., Oude Elferink, Ronald P. J., Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F. J.

“…The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1 ) is the main hepatic transporter of conjugated bile acids, and the entry receptor for…”
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Identification of FDA-approved drugs targeting the Farnesoid X Receptor by van de Wiel, Sandra M. W., Bijsmans, Ingrid T. G. W., van Mil, Saskia W. C., van de Graaf, Stan F. J.

“…The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have…”
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A Compensatory U1snRNA Partially Rescues FAH Splicing and Protein Expression in a Splicing-Defective Mouse Model of Tyrosinemia Type I by Balestra, Dario, Scalet, Daniela, Ferrarese, Mattia, Lombardi, Silvia, Ziliotto, Nicole, C Croes, Chrystal, Petersen, Naomi, Bosma, Piter, Riccardi, Federico, Pagani, Franco, Pinotti, Mirko, van de Graaf, Stan F J

“…The elucidation of aberrant splicing mechanisms, frequently associated with disease has led to the development of RNA therapeutics based on the U1snRNA, which…”
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Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome by Kersseboom, Simone, van Gucht, Anja L M, van Mullem, Alies, Brigante, Giulia, Farina, Stefania, Carlsson, Bo, Donkers, Joanne M, van de Graaf, Stan F J, Peeters, Robin P, Visser, Theo J

“…The thyroid hormone (TH) analog eprotirome (KB2115) was developed to lower cholesterol through selective activation of the TH receptor (TR) β1 in the liver…”
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Fucosyltransferase 2: A Genetic Risk Factor for Primary Sclerosing Cholangitis and Crohn's Disease—A Comprehensive Review by Maroni, Luca, van de Graaf, Stan F. J., Hohenester, Simon D., Oude Elferink, Ronald P. J., Beuers, Ulrich

“…Fucosyltransferase 2 (FUT2) mediates the inclusion of fucose in sugar moieties of glycoproteins and glycolipids. ABO blood group antigens and host-microbe…”
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IgG4-Associated Cholangitis: A Comprehensive Review by Hubers, Lowiek M., Maillette de Buy Wenniger, Lucas J., Doorenspleet, Marieke E., Klarenbeek, Paul L., Verheij, Joanne, Rauws, Erik A., van Gulik, Thomas M., Oude Elferink, Ronald P. J., van de Graaf, Stan F. J., de Vries, Niek, Beuers, Ulrich

“…IgG4-associated cholangitis (IAC) is a major manifestation of immunoglobulin G4-related disease (IgG4-RD), an inflammatory multiorgan disorder of unknown…”
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Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein by Bijsmans, Ingrid T G W, Bouwmeester, Rianne A M, Geyer, Joachim, Faber, Klaas Nico, van de Graaf, Stan F J

“…The NTCP (Na⁺-taurocholate co-transporting protein)/SLC10A [solute carrier family 10 (Nav/bile acid co-transporter family)] 1 is tightly controlled to ensure…”
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Reduced expression of ATP7B affected by Wilson disease–causing mutations is rescued by pharmacological folding chaperones 4‐phenylbutyrate and curcumin by van den Berghe, Peter V. E., Stapelbroek, Janneke M., Krieger, Elmar, de Bie, Prim, van de Graaf, Stan F. J., de Groot, Reinoud E. A., van Beurden, Ellen, Spijker, Ellen, Houwen, Roderick H. J., Berger, Ruud, Klomp, Leo W. J.

“…Wilson disease (WD) is an autosomal recessive copper overload disorder of the liver and basal ganglia. WD is caused by mutations in the gene encoding ATP7B, a…”
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Regulation of TRPV5 and TRPV6 by associated proteins by van de Graaf, Stan F J, Hoenderop, Joost G J, Bindels, René J M

“…The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for…”
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Mutational analysis of ATP8B1 in patients with chronic pancreatitis by van der Woerd, Wendy L, van Haaften-Visser, Désirée Y, van de Graaf, Stan F J, Férec, Claude, Masson, Emmanuelle, Stapelbroek, Janneke M, Bugert, Peter, Witt, Heiko, Houwen, Roderick H J

“…Mutations in genes encoding cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (SPINK1) and chymotrypsinogen C (CTRC) are associated with…”
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Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology by Kunst, Roni F., Verkade, Henkjan J., Oude Elferink, Ronald P.J., Graaf, Stan F.J.

“…Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or…”
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Getting in the zone: Metabolite transport across liver zones by Graaf, Stan F. J., Paulusma, Coen C., In het Panhuis, Wietse

“…The liver has many functions including the regulation of nutrient and metabolite levels in the systemic circulation through efficient transport into and out of…”
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Folding defects in P‐type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4‐phenylbutyrate by van der Velden, Lieke M., Stapelbroek, Janneke M., Krieger, Elmar, van den Berghe, Peter V. E., Berger, Ruud, Verhulst, Patricia M., Holthuis, Joost C. M., Houwen, Roderick H. J., Klomp, Leo W. J., van de Graaf, Stan F. J.

“…Deficiency in P‐type ATP8B1 is a severe and clinically highly variable hereditary disorder that is primarily characterized by intrahepatic cholestasis. It…”
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Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice by Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.

“…The Na+‐taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid…”
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Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection by Herta, Toni, Kersten, Remco, Chang, Jung-Chin, Hubers, Lowiek, Go, Simei, Tolenaars, Dagmar, Paulusma, Coen C., Nathanson, Michael H., Elferink, Ronald Oude, van de Graaf, Stan F.J., Beuers, Ulrich

“…Annexin A11 was identified as autoantigen in IgG4-related cholangitis (IRC), a B-cell driven disease. Annexin A11 modulates calcium-dependent exocytosis, a…”
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Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids by Kersten, Remco, Trampert, David C, Hubers, Lowiek M, Tolenaars, Dagmar, Vos, Harmjan R, van de Graaf, Stan F J, Beuers, Ulrich

“…IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder. Four…”
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Na+‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice by Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Fuchs, Claudia D., Haazen, Lizette C.M., Beuers, Ulrich, Trauner, Michael, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.

“…Accumulation of bile salts (BSs) during cholestasis leads to hepatic and biliary injury, driving inflammatory and fibrotic processes. The Na+‐Taurocholate…”
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Impaired uptake of conjugated bile acids and hepatitis b virus pres1‐binding in na+‐taurocholate cotransporting polypeptide knockout mice by Slijepcevic, Davor, Kaufman, Christina, Wichers, Catharina G.K., Gilglioni, Eduardo H., Lempp, Florian A., Duijst, Suzanne, de Waart, Dirk R., Oude Elferink, Ronald P.J., Mier, Walter, Stieger, Bruno, Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F.J.

“…The Na+‐taurocholate cotransporting polypeptide (NTCP) mediates uptake of conjugated bile acids (BAs) and is localized at the basolateral membrane of…”
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Hepatobiliary acid-base homeostasis: Insights from analogous secretory epithelia by Trampert, David C., van de Graaf, Stan F.J., Jongejan, Aldo, Oude Elferink, Ronald P.J., Beuers, Ulrich

“…Many epithelia secrete bicarbonate-rich fluid to generate flow, alter viscosity, control pH and potentially protect luminal and intracellular structures from…”
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