Search Results - "VAN CAPPELLEN, Wiggert A"

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review by Hoppenbrouwers, Tamara, Autar, Anouchska S A, Sultan, Andi R, Abraham, Tsion E, van Cappellen, Wiggert A, Houtsmuller, Adriaan B, van Wamel, Willem J B, van Beusekom, Heleen M M, van Neck, Johan W, de Maat, Moniek P M

“…Multiple inducers of in vitro Neutrophil Extracellular Trap (NET) formation (NETosis) have been described. Since there is much variation in study design and…”
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Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage by Dinant, Christoffel, Ampatziadis-Michailidis, Giannis, Lans, Hannes, Tresini, Maria, Lagarou, Anna, Grosbart, Malgorzata, Theil, Arjan F., van Cappellen, Wiggert A., Kimura, Hiroshi, Bartek, Jiri, Fousteri, Maria, Houtsmuller, Adriaan B., Vermeulen, Wim, Marteijn, Jurgen A.

“…Chromatin remodeling is tightly linked to all DNA-transacting activities. To study chromatin remodeling during DNA repair, we established quantitative…”
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Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure by Koornneef, Lieke, Slotman, Johan A., Sleddens-Linkels, Esther, van Cappellen, Wiggert A., Barchi, Marco, Tóth, Attila, Gribnau, Joost, Houtsmuller, Adriaan B., Baarends, Willy M.

“…Recombinases RAD51 and its meiosis-specific paralog DMC1 accumulate on single-stranded DNA (ssDNA) of programmed DNA double strand breaks (DSBs) in meiosis…”
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Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase by Slotman, Johan A, Paul, Maarten W, Carofiglio, Fabrizia, de Gruiter, H. Martijn, Vergroesen, Tessa, Koornneef, Lieke, van Cappellen, Wiggert A, Houtsmuller, Adriaan B, Baarends, Willy M

“…The recombinase RAD51, and its meiosis-specific paralog DMC1 localize at DNA double-strand break (DSB) sites in meiotic prophase. While both proteins are…”
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In vivo single cell analysis reveals Gata2 dynamics in cells transitioning to hematopoietic fate by Eich, Christina, Arlt, Jochen, Vink, Chris S, Solaimani Kartalaei, Parham, Kaimakis, Polynikis, Mariani, Samanta A, van der Linden, Reinier, van Cappellen, Wiggert A, Dzierzak, Elaine

“…Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play…”
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Growth factor dependent changes in nanoscale architecture of focal adhesions by Legerstee, Karin, Abraham, Tsion E., van Cappellen, Wiggert A., Nigg, Alex L., Slotman, Johan A., Houtsmuller, Adriaan B.

“…Focal adhesions (FAs) are flat elongated structures that mediate cell migration and link the cytoskeleton to the extracellular matrix. Along the vertical axis…”
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Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends by Dragestein, Katharina A, van Cappellen, Wiggert A, van Haren, Jeffrey, Tsibidis, George D, Akhmanova, Anna, Knoch, Tobias A, Grosveld, Frank, Galjart, Niels

“…Microtubule (MT) plus end-tracking proteins (+TIPs) specifically recognize the ends of growing MTs. +TIPs are involved in diverse cellular processes such as…”
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging by Baar, Marjolein P., Brandt, Renata M.C., Putavet, Diana A., Klein, Julian D.D., Derks, Kasper W.J., Bourgeois, Benjamin R.M., Stryeck, Sarah, Rijksen, Yvonne, van Willigenburg, Hester, Feijtel, Danny A., van der Pluijm, Ingrid, Essers, Jeroen, van Cappellen, Wiggert A., van IJcken, Wilfred F., Houtsmuller, Adriaan B., Pothof, Joris, de Bruin, Ron W.F., Madl, Tobias, Hoeijmakers, Jan H.J., Campisi, Judith, de Keizer, Peter L.J.

“…The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue…”
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Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity by Tamborino, Giulia, De Saint-Hubert, Marijke, Struelens, Lara, Seoane, Dayana C., Ruigrok, Eline A. M., Aerts, An, van Cappellen, Wiggert A., de Jong, Marion, Konijnenberg, Mark W., Nonnekens, Julie

“…Background Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate…”
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Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II by Steurer, Barbara, Janssens, Roel C., Geverts, Bart, Geijer, Marit E., Wienholz, Franziska, Theil, Arjan F., Chang, Jiang, Dealy, Shannon, Pothof, Joris, van Cappellen, Wiggert A., Houtsmuller, Adriaan B., Marteijn, Jurgen A.

“…Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol II) transcription. To study the in vivo dynamics of endogenous Pol…”
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Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci by Dzyubachyk, Oleh, Essers, Jeroen, Cappellen, Wiggert A. van, Baldeyron, Céline, Inagaki, Akiko, Niessen, Wiro J., Meijering, Erik

“…Motivation: Complete, accurate and reproducible analysis of intracellular foci from fluorescence microscopy image sequences of live cells requires full…”
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Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination by Davó-Martínez, Carlota, Helfricht, Angela, Ribeiro-Silva, Cristina, Raams, Anja, Tresini, Maria, Uruci, Sidrit, van Cappellen, Wiggert A, Taneja, Nitika, Demmers, Jeroen A A, Pines, Alex, Theil, Arjan F, Vermeulen, Wim, Lans, Hannes

“…Abstract The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in multiple DNA damage response mechanisms and frequently mutated in…”
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Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells by Roobol, Stefan J, van den Bent, Irene, van Cappellen, Wiggert A, Abraham, Tsion E, Paul, Maarten W, Kanaar, Roland, Houtsmuller, Adriaan B, van Gent, Dik C, Essers, Jeroen

“…High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET radiation types, probably a result of the condensed energy deposition…”
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CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells by Soochit, Widia, Sleutels, Frank, Stik, Gregoire, Bartkuhn, Marek, Basu, Sreya, Hernandez, Silvia C., Merzouk, Sarra, Vidal, Enrique, Boers, Ruben, Boers, Joachim, van der Reijden, Michael, Geverts, Bart, van Cappellen, Wiggert A., van den Hout, Mirjam, Ozgur, Zeliha, van IJcken, Wilfred F. J., Gribnau, Joost, Renkawitz, Rainer, Graf, Thomas, Houtsmuller, Adriaan, Grosveld, Frank, Stadhouders, Ralph, Galjart, Niels

“…The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic…”
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Three-dimensional microscopic analysis of clinical prostate specimens by van Royen, Martin E, Verhoef, Esther I, Kweldam, Charlotte F, van Cappellen, Wiggert A, Kremers, Gert-Jan, Houtsmuller, Adriaan B, van Leenders, Geert J L H

“…Aims Microscopic evaluation of prostate specimens for both clinical and research purposes is generally performed on 5‐μm‐thick tissue sections. Because…”
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Compartmentalization of androgen receptors at endogenous genes in living cells by Yavuz, Selçuk, Kabbech, Hélène, van Staalduinen, Jente, Linder, Simon, van Cappellen, Wiggert A, Nigg, Alex L, Abraham, Tsion E, Slotman, Johan A, Quevedo, Marti, Poot, Raymond A, Zwart, Wilbert, van Royen, Martin E, Grosveld, Frank G, Smal, Ihor, Houtsmuller, Adriaan B

“…Abstract A wide range of nuclear proteins are involved in the spatio-temporal organization of the genome through diverse biological processes such as gene…”
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In vivo live imaging of RNA polymerase II transcription factories in primary cells by Ghamari, Alireza, van de Corput, Mariëtte P C, Thongjuea, Supat, van Cappellen, Wiggert A, van Ijcken, Wilfred, van Haren, Jeffrey, Soler, Eric, Eick, Dirk, Lenhard, Boris, Grosveld, Frank G

“…Transcription steps are marked by different modifications of the C-terminal domain of RNA polymerase II (RNAPII). Phosphorylation of Ser5 and Ser7 by…”
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Repair of exogenous DNA double-strand breaks promotes chromosome synapsis in SPO11-mutant mouse meiocytes, and is altered in the absence of HORMAD1 by Carofiglio, Fabrizia, Sleddens-Linkels, Esther, Wassenaar, Evelyne, Inagaki, Akiko, van Cappellen, Wiggert A., Grootegoed, J. Anton, Toth, Attila, Baarends, Willy M.

“…In mouse spermatocytes and oocytes: •Damage-induced DSBs relocalise to the axial and lateral elements of the SC•Damage-induced DSBs recruit the…”
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Three-dimensional analysis reveals two major architectural subgroups of prostate cancer growth patterns by Verhoef, Esther I., van Cappellen, Wiggert A., Slotman, Johan A., Kremers, Gert-Jan, Ewing-Graham, Patricia C., Houtsmuller, Adriaan B., van Royen, Martin E., van Leenders, Geert J. L. H.

“…The Gleason score is one of the most important parameters for therapeutic decision-making in prostate cancer patients. Gleason growth patterns are defined by…”
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Electron-beam patterned calibration structures for structured illumination microscopy by Hari, Sangeetha, Slotman, Johan A., Vos, Yoram, Floris, Christian, van Cappellen, Wiggert A., Hagen, C. W., Stallinga, Sjoerd, Houtsmuller, Adriaan B., Hoogenboom, Jacob P.

“…Super-resolution fluorescence microscopy can be achieved by image reconstruction after spatially patterned illumination or sequential photo-switching and…”
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