Search Results - "VAN BLEEK, Grada M"

Genetic variability among complete human respiratory syncytial virus subgroup A genomes: bridging molecular evolutionary dynamics and epidemiology by Tan, Lydia, Lemey, Philippe, Houspie, Lieselot, Viveen, Marco C, Jansen, Nicolaas J G, van Loon, Anton M, Wiertz, Emmanuel, van Bleek, Grada M, Martin, Darren P, Coenjaerts, Frank E

“…Human respiratory syncytial virus (RSV) is an important cause of severe lower respiratory tract infections in infants and the elderly. In the vast majority of…”
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Respiratory syncytial virus induced type I IFN production by pDC is regulated by RSV-infected airway epithelial cells, RSV-exposed monocytes and virus specific antibodies by Schijf, Marcel A, Lukens, Michael V, Kruijsen, Debby, van Uden, Nathalie O P, Garssen, Johan, Coenjaerts, Frank E J, Van't Land, Belinda, van Bleek, Grada M

“…Innate immune responses elicited upon virus exposure are crucial for the effective eradication of viruses, the onset of adaptive immune responses and for…”
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Specific Dietary Oligosaccharides Increase Th1 Responses in a Mouse Respiratory Syncytial Virus Infection Model by SCHIJF, Marcel A, KRUIJSEN, Debby, BASTIAANS, Jacqueline, COENJAERTS, Frank E. J, GARSSEN, Johan, BLEEK, Grada M. Van, VAN'T LAND, Belinda

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Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming by Scheeren, Ferenc A, van Bleek, Grada M, Spits, Hergen, Radbruch, Andreas, van Geelen, Caroline M M, Bakker, Arjen Q, Yasuda, Etsuko, Beaumont, Tim, Widjojoatmodjo, Myra N, Diehl, Sean A, Kwakkenbos, Mark J, Bogers, Willy M J M, Mei, Henrik, Lukens, Michaël V

“…Kwakkenbos et al . describe an in vitro method to generate antibody-secreting B cell lines from human peripheral blood memory B cells by transducing them with…”
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The Comparative Genomics of Human Respiratory Syncytial Virus Subgroups A and B: Genetic Variability and Molecular Evolutionary Dynamics by Tan, Lydia, Coenjaerts, Frank E J, Houspie, Lieselot, Viveen, Marco C, van Bleek, Grada M, Wiertz, Emmanuel J H J, Martin, Darren P, Lemey, Philippe

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Respiratory Syncytial Virus-Induced Activation and Migration of Respiratory Dendritic Cells and Subsequent Antigen Presentation in the Lung-Draining Lymph Node by LUKENS, Michaël V, KRUIJSEN, Debby, COENJAERTS, Frank E. J, KIMPEN, Jan L. L, VAN BLEEK, Grada M

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Distinct Abnormalities in the Innate Immune System of Children with Down Syndrome by Bloemers, Beatrijs L.P., MD, van Bleek, Grada M., PhD, Kimpen, Jan L.L., MD, PhD, Bont, Louis, MD, PhD

“…Objective To analyze the frequency and phenotype of cells of the innate immune system in the peripheral blood of children with Down syndrome (DS). Study design…”
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Intranasal Administration of Antibody-Bound Respiratory Syncytial Virus Particles Efficiently Primes Virus-Specific Immune Responses in Mice by Kruijsen, Debby, Einarsdottir, Helga K, Schijf, Marcel A, Coenjaerts, Frank E, van der Schoot, Ellen C, Vidarsson, Gestur, van Bleek, Grada M

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A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants by LUKENS, Michaël V, VAN DE POL, Alma C, KOENDERMAN, Leo, WOLFS, Tom F. W, VAN BLEEK, Grada M, COENJAERTS, Frank E. J, JANSEN, Nicolaas J. G, KAMP, Vera M, KIMPEN, Jan L. L, ROSSEN, John W. A, ULFMAN, Laurien H, TACKE, Carline E. A, VIVEEN, Marco C

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The association between intrauterine inflammation and spontaneous vaginal delivery at term: a cross-sectional study by Houben, Michiel L, Nikkels, Peter G J, van Bleek, Grada M, Visser, Gerard H A, Rovers, Maroeska M, Kessel, Hilda, de Waal, Wouter J, Schuijff, Leontine, Evers, Annemiek, Kimpen, Jan L L, Bont, Louis

“…Different factors contribute to the onset of labor at term. In animal models onset of labor is characterized by an inflammatory response. The role of…”
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Respiratory Syncytial Virus—Specific CD8+ Memory T Cell Responses in Elderly Persons by de Bree, Godelieve J., Heidema, Jojanneke, van Leeuwen, Ester M. M., van Bleek, Grada M., Jonkers, René E., Jansen, Henk M., van Lier, René A. W., Out, Theo A.

“…Background. We investigated respiratory syncytial virus (RSV)—specific CD8+ memory T cell responses in healthy control participants (n= 31 ) and in patients…”
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Characterization of the CD8 + T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice by Lukens, Michaël V., Claassen, Erwin A.W., de Graaff, Patricia M.A., van Dijk, Mariska E.A., Hoogerhout, Peter, Toebes, Mireille, Schumacher, Ton N., van der Most, Robbert G., Kimpen, Jan L.L., van Bleek, Grada M.

“…The BALB/c mouse model for human respiratory syncytial virus infection has contributed significantly to our understanding of the relative role for CD4 + and…”
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Identification of Immunodominant Epitopes Derived from the Respiratory Syncytial Virus Fusion Protein That Are Recognized by Human CD4 T Cells by van Bleek, Grada M, Poelen, Martien C, van der Most, Robbert, Brugghe, Humphrey F, Timmermans, Hans A M, Boog, Claire J, Hoogerhout, Peter, Otten, Henny G, van Els, Cécile A C M

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CD8+ T Cell Responses in Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells of Infants with Severe Primary Respiratory Syncytial Virus Infections by Heidema, Jojanneke, Lukens, Michael V, van Maren, Wendy W. C, van Dijk, Mariska E. A, Otten, Henny G, van Vught, Adrianus J, van der Werff, Desiree B. M, van Gestel, Sjef J. P, Semple, Malcolm G, Smyth, Rosalind L, Kimpen, Jan L. L, van Bleek, Grada M

“…A protective role for CD8+ T cells during viral infections is generally accepted, but little is known about how CD8+ T cell responses develop during primary…”
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Influencing mucosal homeostasis and immune responsiveness: The impact of nutrition and pharmaceuticals by van't Land, Belinda, Schijf, Marcel A., Martin, Rocio, Garssen, Johan, van Bleek, Grada M.

“…Both nutrition and orally ingested drugs pass the gastrointestinal mucosa and may affect the balance between the mucosal immune system and microbial community…”
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Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections by Kruijsen, Debby, Bakkers, Mark J, van Uden, Nathalie O, Viveen, Marco C, van der Sluis, Tetje C, Kimpen, Jan L, Leusen, Jeanette H, Coenjaerts, Frank E, van Bleek, Grada M

“…Following infection with respiratory syncytial virus (RSV), reinfection in healthy individuals is common and presumably due to ineffective memory T cell…”
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RSV 2010: Recent advances in research on respiratory syncytial virus and other pneumoviruses by van Bleek, Grada M, Osterhaus, Albert D.M.E, de Swart, Rik L

“…Abstract Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are important causes of acute respiratory tract disease in infants,…”
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The role of Toll-like receptors in regulating the immune response against respiratory syncytial virus by Klein Klouwenberg, Peter, Tan, Lydia, Werkman, Wendy, van Bleek, Grada M, Coenjaerts, Frank

“…Toll-like receptors (TLRs) play a distinct role in battling respiratory syncytial virus (RSV) infections. However, due to a lack of representative animal…”
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Local innate and adaptive immune responses regulate inflammatory cell influx into the lungs after vaccination with formalin inactivated RSV by Kruijsen, Debby, Schijf, Marcel A, Lukens, Michaël V, van Uden, Nathalie O, Kimpen, Jan L, Coenjaerts, Frank E, van Bleek, Grada M

“…Abstract Inactivated respiratory syncytial virus (RSV) vaccines tend to predispose for immune mediated enhanced disease, characterized by Th2 responses and…”
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Respiratory Syncytial Virus Infection of Monocyte-Derived Dendritic Cells Decreases Their Capacity to Activate CD4 T Cells by de Graaff, Patricia M. A, de Jong, Esther C, van Capel, Toni M, van Dijk, Mariska E. A, Roholl, Paul J. M, Boes, Jolande, Luytjes, Willem, Kimpen, Jan L. L, van Bleek, Grada M

“…Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in children, the elderly, and immune-compromised individuals…”
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