Search Results - "VAN BLADEREN, Peter J"

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2 by van Zanden, Jelmer J., Wortelboer, Heleen M., Bijlsma, Sabina, Punt, Ans, Usta, Mustafa, Bladeren, Peter J. van, Rietjens, Ivonne M.C.M., Cnubben, Nicole H.P.

“…In the present study, the effects of a large series of flavonoids on multidrug resistance proteins (MRPs) were studied in MRP1 and MRP2 transfected MDCKII…”
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A physiologically based biodynamic (PBBD) model for estragole DNA binding in rat liver based on in vitro kinetic data and estragole DNA adduct formation in primary hepatocytes by Paini, Alicia, Punt, Ans, Viton, Florian, Scholz, Gabriele, Delatour, Thierry, Marin-Kuan, Maricel, Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…Estragole has been shown to be hepatocarcinogenic in rodent species at high-dose levels. Translation of these results into the likelihood of formation of DNA…”
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Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling by Punt, Ans, Paini, Alicia, Spenkelink, Albertus, Scholz, Gabriele, Schilter, Benoit, van Bladeren, Peter J, Rietjens, Ivonne M. C. M

“…Estragole is a known hepatocarcinogen in rodents at high doses following metabolic conversion to the DNA-reactive metabolite 1′-sulfooxyestragole. The aim of…”
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Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers by BRAND, Walter, VAN DER WEL, Petronella A. I, REIN, Maarit J, BARRON, Denis, WILLIAMSON, Gary, VAN BLADEREN, Peter J, RIETJENS, Ivonne M. C. M

“…Metabolism and transport from intestinal cells back into the lumen by ATP-binding cassette (ABC) transporters is believed to limit the bioavailability of…”
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Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples by BRAND, Walter, BOERSMA, Marelle G, RIETJENS, Ivonne M. C. M, BIK, Hanneke, HOEK-VAN DEN HIL, Elisabeth F, VERVOORT, Jacques, BARRON, Denis, MEINL, Walter, GLATT, Hansruedi, WILLIAMSON, Gary, VAN BLADEREN, Peter J

“…Phase II metabolism by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) is the predominant metabolic pathway during the first-pass metabolism…”
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Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats by Punt, Ans, Paini, Alicia, Boersma, Marelle G., Freidig, Andreas P., Delatour, Thierry, Scholz, Gabriele, Schilter, Benoît, Bladeren, Peter J. van, Rietjens, Ivonne M. C. M.

“…The extent of bioactivation of the herbal constituent estragole to its ultimate carcinogenic metabolite 1′-sulfooxyestragole depends on the relative levels of…”
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Effect of Glucuronidation on the Potential of Kaempferol To Inhibit Serine/Threonine Protein Kinases by Beekmann, Karsten, de Haan, Laura H. J, Actis-Goretta, Lucas, van Bladeren, Peter J, Rietjens, Ivonne M. C. M

“…To study the effect of metabolic conjugation of flavonoids on the potential to inhibit protein kinase activity, the inhibitory effects of the dietary flavonol…”
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Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations by Al-Subeihi, Ala′ A.A., Alhusainy, Wasma, Kiwamoto, Reiko, Spenkelink, Bert, van Bladeren, Peter J., Rietjens, Ivonne M.C.M., Punt, Ans

“…The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1′-sulfooxymethyleugenol, in the human…”
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Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat by Al-Subeihi, Ala' A.A., Spenkelink, Bert, Punt, Ans, Boersma, Marelle G., van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico derived parameters. With the…”
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A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids by Beekmann, Karsten, Actis-Goretta, Lucas, van Bladeren, Peter J, Dionisi, Fabiola, Destaillats, Frederic, Rietjens, Ivonne M C M

“…Diets rich in flavonoids are associated with various positive health effects. Most in vitro research conducted to elucidate the modes of action of flavonoids…”
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The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ) by Beekmann, Karsten, Rubió, Laura, de Haan, Laura H J, Actis-Goretta, Lucas, van der Burg, Bart, van Bladeren, Peter J, Rietjens, Ivonne M C M

“…The consumption of dietary flavonoids has been associated with a variety of health benefits, including effects mediated by the activation of peroxisome…”
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Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients by Brand, Walter, Schutte, Maaike E., Williamson, Gary, van Zanden, Jelmer J., Cnubben, Nicole H.P., Groten, John P., van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…The transcellular transport of ingested food ingredients across the intestinal epithelial barrier is an important factor determining bioavailability upon oral…”
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In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling by PAINI, Alicia, PUNT, Ans, SCHOLZ, Gabriele, GREMAUD, Eric, SPENKELINK, Bert, ALINK, Gerrit, SCHILTER, Benoît, BLADEREN, Peter J. Van, RIETJENS, Ivonne M. C. M

“…Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure…”
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Association between Consumption of Cruciferous Vegetables and Condiments and Excretion in Urine of Isothiocyanate Mercapturic Acids by Vermeulen, Martijn, van den Berg, Robin, Freidig, Andreas P, van Bladeren, Peter J, Vaes, Wouter H. J

“…A high intake of cruciferous vegetables is associated with a reduced risk of cancer and cardiovascular diseases. This protective effect has been linked to…”
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A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat by Punt, Ans, Freidig, Andreas P., Delatour, Thierry, Scholz, Gabriele, Boersma, Marelle G., Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters…”
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Glutathione conjugation as a bioactivation reaction by van Bladeren, Peter J

“…In general, glutathione conjugation is regarded as a detoxication reaction. However, depending on the properties of the substrate, bioactivation is also…”
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Stereoselective Conjugation, Transport and Bioactivity of S- and R-Hesperetin Enantiomers in Vitro by Brand, Walter, Shao, Jia, Hoek-van den Hil, Elisabeth F, van Elk, Kathelijn N, Spenkelink, Bert, de Haan, Laura H. J, Rein, Maarit J, Dionisi, Fabiola, Williamson, Gary, van Bladeren, Peter J, Rietjens, Ivonne M. C. M

“…The flavanone hesperetin ((±)-4′-methoxy-3′,5,7-trihydroxyflavanone) is the aglycone of hesperidin, which is the major flavonoid present in sweet oranges…”
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Regioselectivity of Phase II Metabolism of Luteolin and Quercetin by UDP-Glucuronosyl Transferases by Boersma, Marelle G, van der Woude, Hester, Bogaards, Jan, Boeren, Sjef, Vervoort, Jacques, Cnubben, Nicole H. P, van Iersel, Marlou L. P. S, van Bladeren, Peter J, Rietjens, Ivonne M. C. M

“…The regioselectivity of phase II conjugation of flavonoids is expected to be of importance for their biological activity. In the present study, the…”
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Human Cytochrome P450 Enzyme Specificity for the Bioactivation of Estragole and Related Alkenylbenzenes by Jeurissen, Suzanne M. F., Punt, Ans, Boersma, Marelle G., Bogaards, Jan J. P., Fiamegos, Yiannis C., Schilter, Benoit, van Bladeren, Peter J., Cnubben, Nicole H. P., Rietjens, Ivonne M. C. M.

“…Human cytochrome P450 enzymes involved in the bioactivation of estragole to its proximate carcinogen 1‘-hydroxyestragole were identified and compared to the…”
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The interplay of glutathione-related processes in antioxidant defense by Cnubben, Nicole H.P, Rietjens, Ivonne M.C.M, Wortelboer, Heleen, van Zanden, Jelmer, van Bladeren, Peter J

“…This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH…”
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